Serum homocysteine and cysteine levels and changes in the lipid profile of children and adolescents over a 12-month follow-up period

Costa, Priscila Ribas de Farias; Kinra, Sanjay; D’Almeida, Vânia; Assis, Ana Marlúcia Oliveira

doi:10.1016/j.clnesp.2017.07.003

Cited by 6 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Positive correlation between serum Tg and Hcy levels that we found in the current study is in correlation with results of other authors [29] and could be explained by inhibition of fatty acid oxidation caused by Hcy which leads to serum Tg elevation [30]. Some in vitro experiments on human cells showed that Hcy induce endoplasmic reticulum stress which leads to higher expression of genes responsible for cholesterol and Tg biosynthesis, as well as their takeover and accumulation in cells [31].…”

Section: Discussionsupporting

confidence: 91%

Association between metabolic syndrome and homocysteinemia in ischemic stroke

Vujnic¹,

Prtina²,

Milivojac³

2021

Biomedicinska istraž.

View full text Add to dashboard Cite

Introduction. Stroke is one of the leading causes of morbidity and mortality worldwide. The relationship between metabolic syndrome (MetS) and homocysteinemia (Hcy) as risk factors for ischemic stroke (IS) is not completely clear. The aim of the study was to determine the frequency of MetS, serum level of Hcy and the frequency of hyperhomocysteinemia (HHcy), as well as their association in patients with IS. Methods. The research included 53 subjects being in rehabilitation after IS and 40 subjects in the control group in rehabilitation due to the back pain problems aged 50-70 years. The diagnosis of the ischemic stroke was established by insight in the medical documentation. All subjects had to have a diagnosis of stroke confirmed by imaging (CT or MR of the endocranium). All subjects in the control group were excluded from the existence of previous stroke, myocardial infarction, angina pectoris and peripheral vascular disease. MetS was defined according to the joint statement from 2009. Results. The frequency of MetS was significantly higher in patients with IS compared to the control group (88.7% vs. 70.0%, p<0.05). The level of Hcy and the frequency of HHcy were increased in the patients with stroke compared to the control group (15.0±5.50 µmol/L vs. 11.2±2.51 µmol/L, p<0.01 and 39.2% vs. 11.4%, p<0.01, respectively). Among patients with IS, those with MetS had higher frequency of HHcy (42.2% vs. 16.7%, p<0.05) and it increased with more individual components of MetS (11.1% in patients with 3 components, 36.8% in patients with 4 components and 64.7% in patients with 5 components, p<0.05). Hcy was also in positive correlation with serum triglyceride level. Conclusion. Our results suggest that MetS and Hcy represent a significant risk factors for IS. It seems that there is an association between these risk factors in pathogenesis of the IS, but further analyses are needed to confirm this hypothesis.

show abstract

Section: Discussionsupporting

confidence: 91%

Association between metabolic syndrome and homocysteinemia in ischemic stroke

Vujnic¹,

Prtina²,

Milivojac³

2021

Biomedicinska istraž.

View full text Add to dashboard Cite

show abstract

“…The majority of studies conducted on healthy children and adolescents have revealed that Hcy levels increase slightly as a function of age, ranging from 4.6 to 10.2 (µm/L) for 4-5 years and 16-19 years, respectively, in males, and from 3.8 to 8.33 (µm/L) for 9 years and 15-19 years, respectively, for females [68][69][70][71]. No trend with age was observed by Dávila-Rodriguez et al [72], even though they found higher levels of Hcy in a group of 56 Mexican children (age: 2-9.99)-up to 11.94 ± 2.03 µm/L-compared to those of non-Hispanic Caucasican children reported in other studies and of other Latin-American pediatric groups [73,74]. Many studies have found gender differences in Hcy levels, with slightly higher Hcy levels in boys than in girls.…”

Section: Children and Adolescentsmentioning

confidence: 64%

“…Many studies have found gender differences in Hcy levels, with slightly higher Hcy levels in boys than in girls. This gender effect is enhanced during and after puberty (>15 years) [68,70,73]. The effect of puberty in increasing Hcy levels may be due to the different creatine turnover rates, with increased creatine production in boys related to their increase of muscle mass.…”

Section: Children and Adolescentsmentioning

confidence: 99%

Homocysteine: Its Possible Emerging Role in At-Risk Population Groups

Azzini

Ruggeri

Polito

2020

IJMS

View full text Add to dashboard Cite

Increased plasma homocysteine is a risk factor for several pathological disorders. The present review focused on the role of homocysteine (Hcy) in different population groups, especially in risk conditions (pregnancy, infancy, old age), and on its relevance as a marker or etiological factor of the diseases in these age groups, focusing on the nutritional treatment of elevated Hcy levels. In pregnancy, Hcy levels were investigated in relation to the increased risk of adverse pregnancy outcomes such as small size for gestational age at birth, preeclampsia, recurrent abortions, low birth weight, or intrauterine growth restriction. In pediatric populations, Hcy levels are important not only for cardiovascular disease, obesity, and renal disease, but the most interesting evidence concerns study of elevated levels of Hcy in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). Finally, a focus on the principal pathologies of the elderly (cardiovascular and neurodegenerative disease, osteoporosis and physical function) is presented. The metabolism of Hcy is influenced by B vitamins, and Hcy-lowering vitamin treatments have been proposed. However, clinical trials have not reached a consensus about the effectiveness of vitamin supplementation on the reduction of Hcy levels and improvement of pathological condition, especially in elderly patients with overt pathologies, suggesting that other dietary and non-dietary factors are involved in high Hcy levels. The importance of novel experimental designs focusing on intra-individual variability as a complement to the typical case–control experimental designs and the study of interactions between different factors it should be emphasized.

show abstract

“…4 d). Elevated homocysteine and cysteine levels are positive predictors of mitochondrial dysfunction and metabolic disturbances, and are linked to methionine metabolism [ 49 , 50 ]. Plasma homocysteine levels were reduced in the PEMF cohort ( Fig.…”

Section: Resultsmentioning

confidence: 99%