1957
DOI: 10.1097/00006250-195706000-00018
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Serum Histaminase During Pregnancy

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2023
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Cited by 14 publications
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“…The rarity of peptic ulcer and of its complications in pregnancy correlate with the hypochlorhydria found in pregnant women and with increased secretions of the anterior pituitary-like hormones in the urine [ 5 ]. An increase in plasma histamine in pregnancy (caused by placental histaminase synthesis) increases metabolism of maternal histamine, thereby reducing gastric acid secretion during pregnancy [ 6 ]. It has also been suggested that female gestational hormones (particularly progesterone) decrease the rate of ulcer formation by increasing gastric mucus synthesis.…”
Section: Discussionmentioning
confidence: 99%
“…The rarity of peptic ulcer and of its complications in pregnancy correlate with the hypochlorhydria found in pregnant women and with increased secretions of the anterior pituitary-like hormones in the urine [ 5 ]. An increase in plasma histamine in pregnancy (caused by placental histaminase synthesis) increases metabolism of maternal histamine, thereby reducing gastric acid secretion during pregnancy [ 6 ]. It has also been suggested that female gestational hormones (particularly progesterone) decrease the rate of ulcer formation by increasing gastric mucus synthesis.…”
Section: Discussionmentioning
confidence: 99%
“…Complications of peptic ulcer disease are rare in pregnancy due to hormonal influences including progesterone and increased plasma histamine levels [17,18]. Its occurrence after cesarean section warrants further evaluation.…”
Section: Discussionmentioning
confidence: 99%
“…Also due to the effect of estrogen, increased levels of diamine oxidase (histaminase) is seen during pregnancy. This enzyme breaks down the histamine that is responsible for the release of hydrochloric acid from the parietal cells in the stomach [4]. Other plausible factors are nutritious diet, rest, avoidance of smoking, alcohol and use of antacids [5].…”
Section: Discussionmentioning
confidence: 99%