Serum high density lipoprotein in diabetic patients

Lopes‐Virella, Maria F.; Stone, Pamela; Colwell, John A.

doi:10.1007/bf01223267

Cited by 164 publications

(36 citation statements)

References 18 publications

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“…The lipoprotein pattern of these diabetics was characterized by an increase of VLDL, slight elevation of LDL and decrease of HDL-cholesterol. Elevated VLDL and total triglyceride combined with low HDL-cholesterol has been recently described in a number of studies in adultonset type diabetes [15][16][17][18]. Schonfeld et al [15] have found that both LDL and HDL are enriched in triglycerides in adult onset type diabetics even without any elevation of serum lipid levels.…”

Section: Discussionmentioning

confidence: 99%

“…The biochemical basis of this relationship lies probably in the fact that part of plasma HDL (mainly HDL2) is generated in the circulation by transfer of cholesterol, phospholipids and apoproteins from triglyceride-rich lipoproteins to HDL during the degradation of the former by endothelial LPL [30][31][32][33][34]. Thus, the low HDL levels observed in both insulin-deficient as well as in adult onset type insulin resistant diabetes [15][16][17][18] could be accounted for by depletion of the insulin-sensitive endothelial LPL The observed slow response of HDL to insulin treatment also fits to this hypothesis since the full replenishment of tissue LPL activity after initiation of insulin treatment appeared also to take relatively long time.…”

Section: Discussionmentioning

confidence: 99%

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Lipoprotein lipase activity of adipose tissue and skeletal muscle in insulin-deficient human diabetes

1979

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Summary.We have previously shown that lipoprotein lipase (LPL) activity of tissues is an important determinant not only of plasma VLDL levels but also of HDL-cholesterol. Studies were designed to investigate whether the serum lipoprotein alterations in uncontrolled insulin-deficient diabetes can be accounted for by changes in LPL activity of tissues. The heparin-releasable LPL activity was determined from biopsy samples of adipose tissue and skeletal muscle in 16 patients with newly detected untreated insulin-deficient diabetes and in 16 age-, sex-and body weight-matched healthy control subjects. Repeat assays were carried out after the patients had been on insulin treatment for an average of two weeks and when the diabetes was well controlled. When untreated the patients had increased concentrations of triglycerides and cholesterol in whole serum and in VLDL and LDL while the HDL cholesterol level was lower than that of controls (p < 0.01). The cholesterol/triglyceride ratio in each of the three lipoproteins was similar in patients and controls. While untreated the diabetic patients had significantly reduced mean LPL activity both in adipose tissue (average 34% of control mean, p < 0.001) and in skeletal muscle (average 45% of control mean, p < 0.05). In the whole group HDL-cholesterol was positively correlated with adipose tissue LPL activity (r = + 0.58, p < 0.001) while log serum total triglyceride and log VLDL-triglyceride showed significant negative correlations with LPL activity of both adipose tissue and skeletal muscle. After initiation of insulin treatment the LPL activity increased significantly (p < 0.01) in both tissues but was still subnormal after 2 weeks. At the same time the VLDL and LDL concentrations had returned to normal while the ItDL-cholesterol remained low. The results suggest that the increase of VLDL and LDL triglyceride and the decrease of HDL-cholesterol present in uncontrolled insulin-deficient diabetes are, at least partly, accounted for by decreased LPL activity of tissues. The restoration of tissue LPL and of serum HDL-eholesterol by insulin are relatively slow processes. The results are consistent with the hypothesis that HDL-cholesterol concentration is dependent on the efficiency of removal of triglyceride-rich lipoproteins from the circulation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lipoprotein lipase activity of adipose tissue and skeletal muscle in insulin-deficient human diabetes

1979

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“…Samples for triacylglycerol, total (Seidel et al, 1983;Kattermann et al, 1984;Wahlefeld, 1974). HDLcholesterol was measured after sedimentation of apo-lipoprotein-B-containing lipoproteins with magnesium-phosphorus-wolfram acid (the precipitant method; Burstein et al, 1970;Lopes-Virella et al, 1977) also from Boehringer, Mannheim. The plasma was measured on a Cobas Mira S (Boehringer Mannheim GmbH, Germany).…”

Section: Laboratory Sampling and Analysesmentioning

confidence: 99%

Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases

et al. 2000

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Objective: To investigate the effect of a probiotic milk product containing the culture CAUSIDO 1 and of two alternative products on risk factors for cardiovascular disease in overweight and obese subjects. Design: An 8 week randomized, double-blind, placebo-and compliance-controlled, parallel study. Subjects: Seventy healthy, weight-stable, overweight and obese (25.0`BMI`37.5 kgam 2 ) males (n 20) and females (n 50), 18 ± 55 y old, were randomly assigned into ®ve groups. Intervention: Four groups consumed 450 ml fermented milk products (yoghurt) daily. Group 1: a yoghurt fermented with two strains of Streptococcus thermophilus and two strains of Lactobacillus acidophilus (StLa). Group 2: a placebo yoghurt fermented with delta-acid-lactone (PY). Group 3: a yoghurt fermented with two strains of Streptococcus thermophilus and one strain of Lactobacillus rhamnosus (StLr). Group 4: a yoghurt fermented with one strain of Enterococcus faecium and two strains of Streptococcus thermophilus (CAUSIDO 1 culture), GAIO 1 (G). The dietary composition of the yoghurt was otherwise similar. The ®fth group was given two placebo pills (PP) daily. Results: When comparing all ®ve treatment groups, unadjusted for changes in body weight, no statistical effects were observed in week 8 in the G-group on low density lipoproteins (LDL)-cholesterol (P 0.29). After adjustment for small changes in body weight, LDL-cholesterol decreased by 8.4% (0.26 AE 0.10 mmolal; P`0.05) and ®brinogen increased (0.74AE 0.32 mmolal; P`0.05) after 8 weeks in the G-group. This was signi®cantly different from the group consuming chemically fermented yoghurt and the group consuming placebo pills (P`0.05). After 8 weeks, systolic blood pressure was signi®cantly more reduced in the StLa and Ggroup compared to StLr. No other differences were found. Conclusion: The CAUSIDO 1 culture reduced LDL-cholesterol and increased ®brinogen in the overweight subjects at a 450 ml consumption daily for 8 weeks. The effect on LDL-cholesterol con®rms previous studies. An immunostimulation by one of the strains in the product might explain the effect on ®brinogen in the G-group.

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“…HDL-Cholesterol was measured in fresh serum (Lopes-Virella et al 1977), and serum LDL-C was calculated from the following formula (Friedewald et al 1972): LDL-C (mg/dl) = TC -[HDL-C + (TG/5)], while atherogenic index was calculated from the following formula (Sagud et al 2009): Atherogenic index = LDL-C / HDL-C The liver glycogen was determined using EnzyChromTM Glycogen Assay Kit (Murat and Serfaty 1974).…”

Section: Experimental Designmentioning

confidence: 99%

Modulation of Diabetes and Dyslipidemia in Diabetic Insulin-Resistant Rats by Mangiferin: Role of Adiponectin and TNF-α

Saleh

El-Maraghy

Reda

et al. 2014

An. Acad. Bras. Ciênc.

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Mangiferin, present in Mangifera indica bark, was reported to produce hypoglycemic and antidiabetic activity in an animal model of genetic type 2 diabetes and in streptozotocin diabetic rats. Its effect on diabetic insulinresistant animals has not been investigated. The current work aimed to explore the effect of mangiferin on diabetic insulin-resistant rat model. Diabetes was induced by high-fat/high fructose diet for eight weeks followed by a subdiabetogenic dose of streptozotocin (HFD-Fr-STZ). Rats were treated with mangiferin (20 mg/kg i.p.) for 28 days starting one week after STZ and its effects were compared to the standard insulin sensitizer, rosiglitazone. HFD-Fr-STZ, induced obesity, hyperglycemia and insulin resistance accompanied by depletion in liver glycogen and dyslipidemia. Moreover, there was an elevation in serum TNF-α and a reduction in adiponectin. Mangiferin ameliorated the consequences of HFD-Fr-STZ and its actions were comparable to the effects of the standard insulin sensitizer, rosiglitazone. The results obtained in this study provide evidence that mangiferin is a possible beneficial natural compound for type 2 diabetes and metabolic disorders associated with the metabolic syndrome. This effect is mediated through improving insulin sensitivity, modulating lipid profile and reverting adipokine levels to normal.

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Serum high density lipoprotein in diabetic patients

Cited by 164 publications

References 18 publications

Lipoprotein lipase activity of adipose tissue and skeletal muscle in insulin-deficient human diabetes

Lipoprotein lipase activity of adipose tissue and skeletal muscle in insulin-deficient human diabetes

Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases

Modulation of Diabetes and Dyslipidemia in Diabetic Insulin-Resistant Rats by Mangiferin: Role of Adiponectin and TNF-α

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