Serum High-Density Lipoprotein Cholesterol and Risk of Non-Hodgkin Lymphoma

Abstract

Lymphoma patients often exhibit abnormal lipid metabolism. Recent evidence, however, suggests that a decrease in circulating high-density lipoprotein cholesterol (HDL-C) may occur during lymphomagenesis, reflecting underlying etiology such as inflammation. We investigated the relationship between prediagnostic HDL-C and non-Hodgkin lymphoma (NHL) in the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study cohort. At baseline, serum HDL-C and total cholesterol concentrations from fasting blood, information on diet and lifestyle, and direct measurements of height, weight, and blood pressure were obtained from 27,074 healthy male smokers of ages 50 to 69 years. Cox proportional hazards models with age as underlying time metric was used to estimate relative risks (RR) and 95% confidence intervals (95% CI). We found no association between total or non-HDL cholesterol and the 201 incident NHL cases ascertained during the follow-up (1985)(1986)(1987)(1988)(1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002), but observed an inverse association between HDL-C and NHL, which changed with length of follow-up. High HDL-C was associated with lower risk of all NHL during the first 10 years (n = 148; RR for 5th versus 1st quintile, 0.35; 95% CI, 0.19-0.62; P trend < 0.0001), but not with diagnoses during later follow-up (n = 53; RR, 1.31; 95% CI, 0.55-3.10). The inverse association was similar for NHL subtypes and was not modified by obesity, blood pressure, physical activity, or alcohol intake, but seemed to be stronger in men with lower duration of smoking (P interaction = 0.06). Our findings implicate HDL-C as a preclinical indicator of NHL and warrant further prospective investigations for its etiologic contribution. [Cancer Res 2007;67(11):5569-74]

Serum triglyceride concentrations and cancer risk in a large cohort study in Austria

“…In addition, an inverse relationship for NHL was observed in our study. Previous reports on cholesterol indicted that reverse causation may substantially contribute to the risk-lowering effect of high blood lipids (Rose and Shipley, 1980;Lim et al, 2007;Strasak et al, 2009). Our observation that STG concentrations were positively associated with kidney cancer incidence in men (data not shown) contrasts with a recently published meta-analysis on BMI and renal cancer risk (Renehan et al, 2008).…”

Systemic Hepatic-Damage Index for Predicting the Prognosis of Hepatocellular Carcinoma after Curative Resection

“…Recent evidence suggests that chronic immuno-inflammatory cells involve in tumorigenesis and tumor progression (Baecklund et al, 2006; Smedby et al, 2006; Lim et al, 2007). Reducing serum HDL concentration leads to chronic inflammation because of its anti-inflammatory properties.…”

“…Recent studies have reported that serum high-density lipoprotein (HDL) is in relation to incident cancers especially breast cancer. These findings imply that HDL might play a major role in tumorigenesis and tumor progression (Lim et al, 2007; Li et al, 2016; Wang et al, 2016). However, an integrated indicator based on serum TC and HDL levels, which might be superior to reflect the correlation between hepatic damage and tumor stages, has not yet been reported in HCC.…”

Metabolic syndrome and renal cell carcinoma

“…An elevated risk of esophageal cancer and colon cancer was observed in people with high levels of TG [36,37], and hypercholesterolemia has been suggested as a risk factor for rectal cancer [36]. High serum CH and TG levels raised the risk of prostate cancer and low HDL levels were associated with breast cancer, lung cancer, and non-Hodgkin’s lymphoma [38-41]. …”