Serum Hepcidin Concentration in Individuals with Sickle Cell Anemia: Basis for the Dietary Recommendation of Iron

Omena, Juliana; Cople‐Rodrigues, Cláudia dos Santos; Cardoso, Jessyca Dias do Amaral; Soares, Andréa; Fleury, Marcos K.; Brito, Flávia dos Santos Barbosa; Koury, Josely Correa; Citelli, Marta

doi:10.3390/nu10040498

Cited by 13 publications

(27 citation statements)

References 29 publications

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“…Serum LDH concentration was analyzed using the continuous ultraviolet kinetics method (Labtest, LabmaxPlenno, Belo Horizonte, MG, Brazil). Hemoglobin variants and quantifications were determined using cation-exchange high-performance liquid chromatography (HPLC), by using the VARIANT II Hemoglobin Testing System (VARIANT ® , Bio-Rad Laboratories, Hercules, CA, USA) [18]. Each hemoglobin variant has its characteristic retention time, established for common variants using the Variant short program.…”

Section: Methodsmentioning

confidence: 99%

Selenium Status and Hemolysis in Sickle Cell Disease Patients

et al. 2019

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Sickle cell disease (SCD) is a genetic hemoglobinopathy characterized by chronic hemolysis. Chronic hemolysis is promoted by increased oxidative stress. Our hypothesis was that some antioxidant micronutrients (retinol, tocopherol, selenium, and zinc) would be determinant factors of the degree of hemolysis in SCD patients. We aimed to investigate the nutritional adequacy of these antioxidants and their relationships to hemolysis. The study included 51 adult SCD patients regularly assisted in two reference centers for hematology in the State of Rio de Janeiro, Brazil. Serum concentrations of retinol, alpha-tocopherol, selenium, and zinc were determined by high-performance liquid chromatography or atomic absorption spectrometry. Hematological parameters (complete blood count, reticulocyte count, hemoglobin, direct and indirect bilirubin, total bilirubin, lactate dehydrogenase) and inflammation markers (leukocytes and ultra-sensitive C-reactive protein) were analyzed. A linear regression model was used to test the associations between the variables. Most patients presented selenium deficiency and low selenium consumption. Linear regression analysis showed that selenium is the main determinant of hemolysis among the antioxidant nutrients analyzed. Thus, data from this study suggest that the nutritional care protocols for patients with SCD should include dietary sources of selenium in order to reduce the risk of hemolysis.

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Section: Methodsmentioning

confidence: 99%

Selenium Status and Hemolysis in Sickle Cell Disease Patients

et al. 2019

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“…A nutritional recommendation for iron intake has not yet been established in SCA. Some studies have shown that serum concentrations of hepcidin are lower in people with SCA without iron overload, which may cause an increase in the intestinal absorption of this nutrient [ 13 ]. On the other hand, transfusion iron overload increases hepcidin synthesis [ 13 ] and could promote a reduction in the intestinal absorption of iron.…”

Section: Discussionmentioning

confidence: 99%

“…The contribution of dietary iron to IOL in patients with SCA is uncertain [ 12 ]. Nevertheless, uncertainties regarding food consumption and iron absorption rates lead to unreliable recommendations for dietary iron restriction [ 13 , 14 ]. Excess iron is toxic because it leads to the oxidation of fundamental biological compounds [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Food Consumption of People with Sickle Cell Anemia in a Middle-Income Country

et al. 2023

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Sickle cell anemia (SCA) is a genetic and hemolytic disease globally characterized by social vulnerability. Food consumption has been insufficiently analyzed in SCA. Secondary iron overload is often observed. This leads to unreliable recommendations for dietary iron restriction. We assessed food consumption and iron intake among adults with SCA. Considering the guidelines for healthy eating, foods were grouped according to the NOVA classification. This transversal study included 74.4% of eligible patients who were registered in the reference center for SCA treatment in Rio de Janeiro, Brazil, in 2019. Data on food consumption were collected through 24 h recall. The monthly household income of 82.3% of patients was less than $770. The consumption of fresh or minimally processed foods was directly associated with monthly household income (p < 0.0001; η2 = 0.87). Ultra-processed foods provided more than one-third of the total energy intake (35.2%). The prevalence of inadequate iron intake was about 40% among women, while that of iron intake above the tolerable upper limit was 0.8%. People from lower socioeconomic classes had the lowest iron intake. Strategies to encourage the consumption of fresh or minimally processed foods are needed considering the requirement of an antioxidant diet in SCA. These findings highlight the need for health equity to ensure food security and healthy eating in SCA.

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“…12 Hepcidin appears to be suppressed, which may be related to the rise in erythropoiesis brought on by the disease's distinctive anemia and, as a result, increase intestinal iron absorption. 13 CKD is a chronic inflammatory state where there is elevation of inflammatory cytokines like IL-6, TNF-α, IL-1, IFN-γ, and acute phase reactants such as hepcidin, hsCRP, and Ferritin. Despite of improvement in treatment modalities such as dialysis over the past decades, the morbidity and mortality in CKD still remains high.…”

Section: Discussionmentioning

confidence: 99%

Serum level of hepcidin in chronic kidney disease - A hospital-based study from South India

Indirajith

Sivagnanam²,

Rajappa

2022

Asian J Med Sci

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Background: The term “chronic kidney disease (CKD)” refers to a variety of pathophysiologic conditions characterized by impaired kidney function and a steady fall in glomerular filtration rate. CKD is a slowly progressive silent epidemic that affects approximately 12% of the world population. Aims and Objectives: The aim of the study was to estimate the level of serum Hepcidin in patients with CKD compared to healthy controls. Materials and Methods: Hundred subjects both male and female over the age of 18 were included in the study and informed consent was obtained from each of them. The study population was divided equally into two groups. Blood serum was collected to estimate level of hepcidin, urea, creatinine, ferritin, iron, total iron binding capacity, hs C-reactive protein (CRP), and total proteins. Urine was collected in a sterile container for urine protein creatinine ratio. Results: Hepcidin could be a prognostic marker in the clinical outcome of CKD especially in the progression of CKD. There was a highly significant positive correlation of serum Hepcidin with hsCRP, ferritin, creatinine, urea, urine protein creatinine ratio, and erythrocyte sedimentation rate. Significant negative correlation of serum Hepcidin with Creatinine Clearance, Iron, TIBC, Transferrin saturation, Hemoglobin, and Total Proteins had been observed. Conclusion: The current study showed that patients with CKD and anemia have considerably higher serum hepcidin concentrations. The level of hepcidin increases as disease progresses in CKD patients. Hepcidin, mediator of anemia in CKD is the potential target to treat anemia in them to prevent death due to cardiovascular complications and improve their quality of life.

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Serum Hepcidin Concentration in Individuals with Sickle Cell Anemia: Basis for the Dietary Recommendation of Iron

Cited by 13 publications

References 29 publications

Selenium Status and Hemolysis in Sickle Cell Disease Patients

Selenium Status and Hemolysis in Sickle Cell Disease Patients

Food Consumption of People with Sickle Cell Anemia in a Middle-Income Country

Serum level of hepcidin in chronic kidney disease - A hospital-based study from South India

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