Serum heat shock protein 70 in preeclampsia and normal pregnancy: A systematic review and meta-analysis

Abstract

Background:Preeclampsia, a severe complication of human pregnancy is one of the main causes of maternal, fetal, and neonatal morbidity and mortality with unclear pathogenesis. Heat shock protein 70 (HSP70) is one of the factors that can mediate cytoprotective, antiapoptotic, and immune regulatory effects.Objective:This meta-analysis was performed with aim to evaluate HSP70 in preeclampsia and normal pregnancy.Materials and Methods:The original publications reporting the serum HSP70 levels in preeclampsia and normal pregnancies published before November 2015 were identified by searching PubMed Central, Scopus, and ISI Web of Knowledge databases by two researchers, separately. The keywords were” preeclampsia” and “HSP70” or “Heat shock protein 70” Statistical analyses were performed using STATA software (version 11).Results:Out of 127 studies, seven eligible case-control studies were identified which consists of 350 preeclampsia and 429 normal pregnancies. Our pooled analysis of data from 7 studies which met the inclusion criteria, provides evidence that there is a significant association between HSP70 and preeclampsia. Cochran's test results showed the heterogeneity of the studies (p<0.001) and the I2 index was 91%. The standardized mean differences (SMD) based on a random effect model with trim and fill method was 0.92 (95% CI: 0.33-1.51); also there was a significant association between HSP70 and preeclampsia (Z=3.07, p=0.002).Conclusion: The results showed that serum HSP70 concentration was significantly higher in preeclamptic patients than the control group. Therefore HSP70 may be identified as a diagnostic factor.

SARS-CoV-2 infection in pregnancy is associated with robust inflammatory response at the maternal-fetal interface

“…Hsp70 is associated with endothelial activation in placental vascular disease (25) and serum levels are increased in cases of preeclampsia (24,47,48). Hsp70 levels are furthermore significantly elevated in patients exhibiting hemolysis, elevated liver enzymes, and low platelet count (HELLP syndrome) compared to patients with severe preeclampsia without HELLP syndrome (24,49).…”

HSPA1L rs1061581 polymorphism is associated with the risk of preeclampsia in Han Chinese women

“…PE is a common systemic obstetric disorder whose specific pathogenesis has not yet been fully explained. However, it is becoming increasingly accepted that oxidative stress, and maternal systemic inflammatory response have a key role in the pathogenesis of PE [8,15,16], which may induce the expression of HSP70 [18].…”

“…As a stress protein, HSP70 plays a pivotal role in protecting cells against apoptosis, oxidative damage and genetic damage [17]. Placental ischemia, oxidative stress and maternal systemic inflammatory response, which play important roles in the pathogenesis of PE, have been shown to induce the expression of HSP70 [18]. Moreover, studies indicated that HSP70 is involved in the pathogenesis of hypertension and associated diseases such as coronary heart disease, atherosclerosis, ischaemic stroke, Parkinson's disease, high-altitude illness and the forth, and there were high levels of HSP70 in serum, plasma and placental tissue of PE patients [17,19,20].…”

Potential Protein Biomarkers for Preeclampsia

“…Studies had found that serum HSP70 in PE patients was significantly higher, but Livingston et al [found that the serum HSP70 in patients with severe PE was not higher than that in normal pregnant women [42][43][44]. Based on this disagreement, Saghafi et al conducted a meta-analysis and found that the serum HSP70 in patients with PE was significantly higher than that in normal pregnant women, although only seven studies were included [45]. Moreover, Hromadnikova et al found that the mRNA level of HSP70 in patients with PE is high, but it has nothing to do with the severity of the disease [46] .…”