Serum heat shock protein 70 levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in women with preeclampsia

Molvarec, Attila; Szarka, András; Walentin, Szilvia; Bekő, Gabriella; Karádi, István; Prohászka, Zoltán; Rigó, János

doi:10.1016/j.cca.2011.06.042

Cited by 53 publications

(53 citation statements)

References 38 publications

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“…In an another study, a significant difference between serum levels of preeclamptic and normotensive pregnants for parameters of IL4, IL6 and IL10 was observed [26]. In our study we observed significantly high IFN-g and TGF-b levels in preeclamptic pregnants compared to those in healty pregnants.…”

Section: Discussionsupporting

confidence: 64%

Are There Any Differences Between the Distribution of Placental Bed Leukocyte Subtypes and Plasma Cytokine Levels of Preeclamptic and Healthy Pregnants?

Özkan

Devici

Şi̇mşek

et al. 2017

Journal of Advanced Medical Sciences and Applied Technologies

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Objectives: Preeclampsia (PE) is associated with impaired decidual leukocyte and plasma cytokine balance compared with normal pregnancy. We aimed to investigate maternal plasma levels of Interferon-gamma (IFN-g), Tumor Necrosis Factor-alpha (TNF-a), Transforming Growth Factor-beta (TGF-b), Interleukin-4 (IL4), IL6, IL10, IL17, IL35, suppressor of Cytokine Signalling-3 (SOCS3) and placental bed leukocytes in preeclamptic and healthy pregnants. Materials & Methods:This study was conducted with 40 preeclamptic and 40 normotensive pregnants. Cytokine levels were studied with enzyme-linked immunosorbent assay. CD8, CD56 and CD163 antigens were analysed by immunohistochemical study on placental bed biopsies. Results:In preeclamptic women; IFN-g and TGF-b levels were significantly higher and IL-35 levels were significantly lower than those of controls. CD8, CD56 and CD163 positivity of preeclamptic group were not significantly higher than those of controls. CD8 staining showed negative correlation with plasma IL17 levels. CD163 staining showed negative correlation with TNF-a/IL4 ratio. TNF-a/IL4 ratio showed minimal influence on placental bed CD163 staining. Conclusion:Slightly increased placental bed CD8, CD56 and CD163 positive leukocytes and increased plasma IFN-g, TGF-b and decreased plasma IL35 levels of preeclamptic pregnants indicate an aberrant cell mediated immunity in PE. We could not say yet that this condition is whether result or reason. New studies are needed to discuss our results.

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Section: Discussionsupporting

confidence: 64%

Are There Any Differences Between the Distribution of Placental Bed Leukocyte Subtypes and Plasma Cytokine Levels of Preeclamptic and Healthy Pregnants?

Özkan

Devici

Şi̇mşek

et al. 2017

Journal of Advanced Medical Sciences and Applied Technologies

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“…The expression of HSPs is known to be involved in an endogenous cellular defense mechanism that enables cells to cope with stressful conditions that induce inflammation and oxidative stress [7,27]. In fact, induction of HSP caused by acute heat stress increased the production of pro-inflammatory cytokines such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and IL-6, which can eventually lead to hemorrhage and necrosis in multiple organs including the liver, heart, and brain [5,16].…”

Section: Introductionmentioning

confidence: 99%

Effects of Cyclic Heat Stress or Vitamin C Supplementation during Cyclic Heat Stress on HSP70, Inflammatory Cytokines, and the Antioxidant Defense System in Sprague Dawley Rats

et al. 2012

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A total of 21 male SD rats were divided into three groups to investigate the effects of consecutive cyclic heat stress or vitamin C under heat stress on heat shock protein (HSP) 70, inflammatory cytokines, and antioxidant systems. The heat stress (HS) and vitamin C supplementation during heat stress (HS+VC) groups were exposed to cyclic heat stress (23 to 38 to 23°C) for 2 h on each of seven consecutive days. The HS+VC group had free access to water containing 0.5% vitamin C throughout the experiment. Hepatic HSP70 mRNA in the HS group was significantly (P<0.05) higher than that in the control (CON) or HS+VC group. The mRNA levels of tumor necrosis factor (TNF)-α and inducible nitric oxide synthase (iNOS) in the HS group were greater (P<0.05) than those in the CON group. The HS+VC group showed significantly (P<0.05) lower mRNA levels of hepatic interleukin-6 and TNF-α than the HS group. However, thymic HSP70 and inflammatory cytokines were unaffected by treatments. In the hepatic antioxidant system, the mRNA and activity of glutathione peroxidase (GPX) were greater (P<0.05) in the HS than in the CON group, whereas the HS+VC group showed markedly (P<0.05) lower GPX mRNA and activity than the HS group. However, superoxide dismutase, glutathione S-transferase, and malondialdehyde were unaffected by treatments. In conclusion, cyclic heat stress activated hepatic HSP70, TNF-α, iNOS, and GPX genes, whereas vitamin C during heat stress ameliorated heat stress-induced cellular responses in rats.

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“…Physiologically, the VCAM-1 and ICAM-1 are present in the membranes of endothelial cells in low expressions. When the stimulus presence, this molecule will upregulated [4]. In preeclampsia, this adhesion molecules levels showed significant correlations with blood pressure values, renal and liver function markers [5].…”

Section: Introductionmentioning

confidence: 92%

Syzygium Cumini Reduces Vcam-1 and Icam-1 Expression in Endothelial Cells Induced by Plasma from Preeclamptic Patients

Wulandari¹,

Winarsih²,

Baktiyani³

2016

Med-Science

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The present study sought to investigate a role for Syzygium cumini on VCAM-1 and ICAM-1 expression in endothelial cells induced by plasma from preeclamptic patients. Endothelial cells were obtained from human umbilical vascular endothelial cells. At confluency, endothelial cells were divided into five groups, which included control (untreated), endothelial cells exposed to 2% plasma from preeclamptic patients (PP), endothelial cells exposed to PP in the presence of ethanolic extract of Syzygium cumini (PP + SC

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Serum heat shock protein 70 levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in women with preeclampsia

Cited by 53 publications

References 38 publications

Are There Any Differences Between the Distribution of Placental Bed Leukocyte Subtypes and Plasma Cytokine Levels of Preeclamptic and Healthy Pregnants?

Are There Any Differences Between the Distribution of Placental Bed Leukocyte Subtypes and Plasma Cytokine Levels of Preeclamptic and Healthy Pregnants?

Effects of Cyclic Heat Stress or Vitamin C Supplementation during Cyclic Heat Stress on HSP70, Inflammatory Cytokines, and the Antioxidant Defense System in Sprague Dawley Rats

Syzygium Cumini Reduces Vcam-1 and Icam-1 Expression in Endothelial Cells Induced by Plasma from Preeclamptic Patients

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