Serum HCG measured in the peri-implantation period predicts IVF cycle outcomes

Shapiro, B.S.; Daneshmand, S.T.; Restrepo, Humberto; Garner, Forest C.

doi:10.1016/j.rbmo.2012.05.015

Cited by 20 publications

(13 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, the clinical pregnancy rates, ongoing pregnancy rates, and delivery rates, as well as the post‐clinical pregnancy loss, were similar in the three highest hCG‐quartiles. These new results contrast previous findings of a continued increase in pregnancy success with higher early p‐hCG levels . But the previous studies included transfers of more than one embryo, which may explain the difference.…”

Section: Discussioncontrasting

confidence: 96%

“…After implantation, human chorionic gonadotropin (hCG) is the first trophoblast signal detected in maternal blood and is used to diagnose pregnancy (1). Early plasma hCG (p-hCG) levels are predictive of pregnancy outcome (2)(3)(4)(5)(6)(7)(8)(9)(10)(11) and are routinely measured in in vitro fertilization (IVF) clinics to plan early pregnancy followup. Very few studies are restricted to single embryo transfer (SET) (5,11), and no studies have focused on Day-2 SET.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Predictive value of plasma human chorionic gonadotropin measured 14 days after Day‐2 single embryo transfer

Løssl

Oldenburg

Toftager

et al. 2017

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Predictive value of plasma human chorionic gonadotropin measured 14 days after Day‐2 single embryo transfer

Løssl

Oldenburg

Toftager

et al. 2017

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

show abstract

“…In this context, we should mention that blastocyst-stage transfer is associated with higher percentage of biochemical pregnancy losses per embryo transfer (14.1%, 108/767) [59] than cleavage-stage transfer (8.2%, 154/1888) [60]. …”

Section: Methodsmentioning

confidence: 99%

Changes in sex ratio from fertilization to birth in assisted-reproductive-treatment cycles

Tarı́n

Garcı́a-Pérez

Hermenegildo

et al. 2014

Reprod Biol Endocrinol

View full text Add to dashboard Cite

BackgroundIn Western gender-neutral countries, the sex ratio at birth is estimated to be approximately 1.06. This ratio is lower than the estimated sex ratio at fertilization which ranges from 1.07 to 1.70 depending on the figures of sex ratio at birth and differential embryo/fetal mortality rates taken into account to perform these estimations. Likewise, little is known about the sex ratio at implantation in natural and assisted-reproduction-treatment (ART) cycles. In this bioessay, we aim to estimate the sex ratio at fertilization and implantation using data from embryos generated by standard in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) in preimplantation genetic diagnosis cycles. Thereafter, we compare sex ratios at implantation and birth in cleavage- and blastocyst-stage-transfer cycles to propose molecular mechanisms accounting for differences in post-implantation male and female mortality and thereby variations in sex ratios at birth in ART cycles.MethodsA literature review based on publications up to December 2013 identified by PubMed database searches.ResultsSex ratio at both fertilization and implantation is estimated to be between 1.29 and 1.50 in IVF cycles and 1.07 in ICSI cycles. Compared with the estimated sex ratio at implantation, sex ratio at birth is lower in IVF cycles (1.03 after cleavage-stage transfer and 1.25 after blastocyst-stage transfer) but similar and close to unity in ICSI cycles (0.95 after cleavage-stage transfer and 1.04 after blastocyst-stage transfer).ConclusionsIn-vitro-culture-induced precocious X-chromosome inactivation together with ICSI-induced decrease in number of trophectoderm cells in female blastocysts may account for preferential female mortality at early post-implantation stages and thereby variations in sex ratios at birth in ART cycles.

show abstract

“…Moreover, previous studies (12,16) demonstrated a correlation between β-hCG levels after embryo transfer and pregnancy outcomes. However, these studies evaluated the interrelationship between β-hCG levels and successful pregnancy in cleavage stage embryo transfer or multiple embryo transfer cases; β-hCG levels after SVBT were not previously analyzed.…”

Section: Patients Groupmentioning

confidence: 86%

“…Recently, some studies reported that serum β-hCG levels measured at an earlier time point could be used to predict pregnancy outcome [15,16]. These studies demonstrated that early serum β-hCG levels 5 days after blastocyst transfer can predict pregnancy rates, including spontaneous abortions and EP.…”

Section: Introductionmentioning

confidence: 99%

Maternal age and initial β-hCG levels predict pregnancy outcome after single vitrified-warmed blastocyst transfer

Ueno¹,

Ezoe²,

Abe³

et al. 2014

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose We retrospectively examined a large cohort of females who underwent single blastocyst transfer to determine if initial β-human chorionic gonadotrophin (β-hCG) levels on day 7 after single vitrified-warmed blastocyst transfer (SVBT) could be used to predict pregnancy outcome. Methods The treatment cycles that gave rise to the early pregnancies included in this study were performed from 2004 to 2011 in a private infertility center. In SVBT cycles, embryos were transferred during a natural cycle or after endometrial preparation with exogenous estrogen and progesterone. A total of 11,458 cycles with β-hCG levels ≥1.0 UI/ml on day 7 after SVBT were evaluated. The proportion of live births per positive β-hCG cycle was established for 10 β-hCG ranges in 3 different age groups (Group A: 21-34 years old; Group B: 35-39 years old; Group C: 40-44 years old). Results The proportion of live births gradually increased from 1.5 to 93.7 %, 0.8 to 87.9 %, and 0.6 to 76.2 % in Groups A, B, and C, respectively. For each range of β-hCG levels, the proportion of live births was higher for the younger age group, which reflected the increased risk of early pregnancy loss with advancing female age. Conclusions β-hCG levels on day 7 after SVBT, in conjunction with maternal age, may be used to predict pregnancy outcomes.

show abstract

Serum HCG measured in the peri-implantation period predicts IVF cycle outcomes

Cited by 20 publications

References 15 publications

Predictive value of plasma human chorionic gonadotropin measured 14 days after Day‐2 single embryo transfer

Predictive value of plasma human chorionic gonadotropin measured 14 days after Day‐2 single embryo transfer

Changes in sex ratio from fertilization to birth in assisted-reproductive-treatment cycles

Maternal age and initial β-hCG levels predict pregnancy outcome after single vitrified-warmed blastocyst transfer

Contact Info

Product

Resources

About