Serum Growth Hormone Levels in Provocation Tests and During Nocturnal Spontaneous Secretion: a Comparative Study<sup>1</sup>

Bierich, J. R.

doi:10.1111/j.1651-2227.1987.tb17129.x

Cited by 26 publications

(7 citation statements)

References 10 publications

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“…However, the reality of this distinction is still a matter of discussion and is not universally accepted. In fact, this form of GH deficiency emphasizes the exis tence of a discrepancy between the results of pharmaco logical tests and the study of endogenous 24-hour secre tion [6,7], The term 'low endogenous secretors' better defines the reality of this anomaly than NSD, which implies a physiopathological mechanism not yet clari fied.…”

Section: Discussionmentioning

confidence: 99%

Growth Hormone Treatment in Patients with Neurosecretory Dysfunction

Rochiccioli¹,

Dechaux²,

Tauber³

et al. 1990

Horm Res

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Twenty-four children (14 boys and 10 girls) with neurosecretory dysfunction, defined by a response > 10 ng/ml to two pharmacological tests, and 24-hour GH secretion < 3 ng/ml/min, were treated with biosynthetic hGH. Mean age was 10 years 8 months ± 3 years 6 months. Growth retardation was -2.8 ± 0.8 SD. Eighteen children were prepubertal and six pubertal (P2). Mean peaks in two pharmacological stimulation tests were 25.8 ± 14.8 and 20.8 ± 11.5 ng/ml. Somatomedin C/insulin-like growth factor I level was 0.8 ± 0.6 IU/ml in the prepubertal children. Twenty-four-hour integrated concentration of GH was low, at 2.2 ± 0.5 ng/ml/min. Analysis of secretory profiles showed 3 types: (1) hyperpulsatile profile with numerous peaks of low amplitude, (2) flat profile, (3) profile with an isolated peak > 10 ng/ml. Treatment with hGH (0.42 IU/kg/week) resulted in an increase in growth velocity from 4.9 ± 1.2 to 6.8 ± 2.2 cm/year. These results are comparable to those of a group with total GH deficiency receiving the same dose. Analysis of the results showed a group of good responders (n = 14, growth velocity: 8.1 cm/year) and a group of poor responders (n = 10, growth velocity: 4.9 cm/year). Thus, treatment of neurosecretory dysfunction with hGH gives results comparable to those obtained in classic GH secretory dysfunction.

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Section: Discussionmentioning

confidence: 99%

Growth Hormone Treatment in Patients with Neurosecretory Dysfunction

Rochiccioli¹,

Dechaux²,

Tauber³

et al. 1990

Horm Res

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show abstract

“…These tests also involve multiple venepuncture, and some may have unwanted side-effects, especially in small children (Shah et al, 1992). Nocturnal or 24-hour blood sampling has provided an alternative to pharmacological testing (Spiliotis et al, 1984;Bercu et al, 1986;Bierich, 1987;Zadik et al, 1990). Such an assessment of spontaneous GH secretion requires repeated blood sampling from an indwelling cannula, requiring a minimum 15-20-minute sampling interval (Hindmarsh et al, 1989) which yields 72-96 blood samples/ 24 h/patient.…”

mentioning

confidence: 99%

Current methods for the measurement of growth hormone in urine

Hourd

Edwards

1994

Clinical Endocrinology

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“…From our own investigations ( fig. 7) it emerges that not only the peaks in the provocation tests disappear but that GH secretion is totally suppressed [78], Hence the strongest anabolic hormone of the organism is missing. This find ing helps to interpret the main symptoms of Cushing's syndrome, growth stop, retarded skeletal maturation, osteoporosis and atrophy of the cutis.…”

Section: Special Indicationsmentioning

confidence: 99%

Therapy with Growth Hormone – Old and New Indications

Bierich

1989

Horm Res

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Pituitary dwarfism with severe growth hormone deficiency (GHD) represents the classical indication for treatment by recombinant human growth hormone (hGH). With continuous GH replacement and early start of treatment, normal adult height can be achieved. During puberty the dosage of hGH administered should be increased. Numerous growth disorders do not coincide with major GHD as determined by provocative tests but only with diminished spontaneous hormone secretion. Typical examples are constitutional delay of growth and adolescence and growth retardation after irradiation of the skull. Also in these disorders treatment by recombinant hGH in replacement doses renders favorable results. The more normal the spontaneous GH secretion is, e.g. in familial short stature and in skeletal dysplasias, the higher doses of GH are needed to stimulate growth. For treatment of patients with Turner’s syndrome a combined therapy with high doses of GH and with oxandrolone has proven rather effective. With endogenous and exogenous hypercortisolism the metabolic balance is shifted towards catabolism and spontaneous GH secretion is depressed. In such situations, e.g. after severe traumas, operations, infections and combustions, administration of GH can be rather helpful. Recent trials in children with stunted growth due to chronic renal insufficiency show that it is possible also in this condition to effectively stimulate growth by hGH.

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Serum Growth Hormone Levels in Provocation Tests and During Nocturnal Spontaneous Secretion: a Comparative Study¹

Cited by 26 publications

References 10 publications

Growth Hormone Treatment in Patients with Neurosecretory Dysfunction

Growth Hormone Treatment in Patients with Neurosecretory Dysfunction

Current methods for the measurement of growth hormone in urine

Therapy with Growth Hormone – Old and New Indications

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Serum Growth Hormone Levels in Provocation Tests and During Nocturnal Spontaneous Secretion: a Comparative Study1

Cited by 26 publications

References 10 publications

Growth Hormone Treatment in Patients with Neurosecretory Dysfunction

Growth Hormone Treatment in Patients with Neurosecretory Dysfunction

Current methods for the measurement of growth hormone in urine

Therapy with Growth Hormone &ndash; Old and New Indications

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Product

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Serum Growth Hormone Levels in Provocation Tests and During Nocturnal Spontaneous Secretion: a Comparative Study¹

Therapy with Growth Hormone – Old and New Indications