Serum glucose/potassium ratio as a clinical risk factor for aneurysmal subarachnoid hemorrhage

Fujiki, Yu; Matano, Fumihiro; Mizunari, Takayuki; Murai, Yasuo; Tateyama, Kojiro; Koketsu, Kenta; Kubota, Asami; Kobayashi, Shiro; Morita, Akio

doi:10.3171/2017.5.jns162799

Cited by 42 publications

(43 citation statements)

References 33 publications

(27 reference statements)

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“…Recently, Fujiki et al reported that serum GPR, glucose and potassium level at admission were significantly correlated with poor outcome at 3 months ( 7 ). Our results do not entirely coincide with their results.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, some clinical studies have reported that hyperglycemia is related with the risk of poor outcome and delayed cerebral ischemia (DCI) after aSAH ( 5 , 6 ). Recent reports have suggested that the glucose to potassium ratio (GPR) is significantly correlated with cerebral vasospasm and functional outcome ( 7 , 8 ). The purpose of the present study was to calculate the plasma GPR in patients with aSAH and to determine whether this ratio is associated with the risk of 3-month mortality.…”

Section: Introductionmentioning

confidence: 99%

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Association of Plasma Glucose to Potassium Ratio and Mortality After Aneurysmal Subarachnoid Hemorrhage

et al. 2021

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Objectives: Hyperglycemia and hypokalemia are common problems in patients with aneurysmal subarachnoid hemorrhage (aSAH). The aim of this study was to determine whether the plasma glucose to potassium ratio (GPR) predicts mortality due to aSAH.Methods: We prospectively recruited aSAH patients and healthy controls between March 2007 and May 2017. Clinical outcomes included mortality and poor outcome (modified Rankin scale score of 3-6) after 3 months. Multivariable analysis was used to determine the association between plasma GPR and 3-month mortality in aSAH patients.Results: A total of 553 patients were recruited, and the mortality rate was 11%. The GPR was significantly elevated in aSAH patients compared with controls, in patients with a poor outcome than with a good outcome and in non-survivals than in survivals. Multivariable analysis showed that the plasma GPR was an independent factor associated with 3-month mortality. The area under the curve of the GPR was 0.747 in predicting 3-month mortality.Conclusion: The plasma GPR on admission has potential as a predictor of 3-month mortality in patients with aSAH.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Plasma Glucose to Potassium Ratio and Mortality After Aneurysmal Subarachnoid Hemorrhage

et al. 2021

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“…24 Fujiki et al reported that a high serum GLU/K ratio in patients with aneurysmal SAH would be useful in predicting poor prognosis. 25 Park et al suggested that catecholamine crises in globus pallidus and deep white matter were key pathophysiologic factors in CO intoxication. 26 In another study, norepinephrine and dopamine were found to be high in pericardial and cerebrospinal fluids in patients who died of CO intoxication.…”

Section: Discussionmentioning

confidence: 99%

Assessment of serum glucose/potassium ratio as a predictor for delayed neuropsychiatric syndrome of carbon monoxide poisoning

et al. 2020

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Introduction: Carbon monoxide (CO) poisoning is a crucial cause of delayed neuropsychiatric syndrome (DNS). However, most biomarkers are not satisfactory for the prediction of DNS caused by CO poisoning. Thus, we evaluated the adequacy of the serum glucose/potassium (GLU/K) ratio, which may be an easy, quick, and readily available parameter that can be used in the emergency department for predicting DNS. Methods: We evaluated 281 patients who were admitted to our emergency department between January 2012 and December 2018. The patients were divided into two groups: DNS (+) and DNS (−). The GLU/K was compared for the groups. Results: Glucose, blood urea nitrogen, carboxyhemoglobin, and GLU/K ratios of patients in the DNS (+) group were statistically significantly higher than those patients in DNS (−) group (140 ± 34 vs. 110 ± 24, p < 0.001; 17.58 ± 6.14 vs. 14.27 ± 5.08, p = 0.003; 29 ± 5.1 vs. 18.9 ± 7.6, p < 0.001; and 38.35 ± 10.11 vs. 28.65 ± 6.53, p < 0.001, respectively). The area under the curve for GLU/K to predict DNS was measured as 0.791, and 35.9 as a cut-off value had 63.6% sensitivity and 89.6% specificity. Conclusions: DNS development in CO poisoning is a serious and feared complication. We suggest that the GLU/K ratio has a high potential as a rapid, easy preliminary marker for the exclusion of patients who will not subsequently develop DNS.

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“…8 Additionally, these changes have been found in some diseases involving acute brain injury, such as severe traumatic brain injury and aneurysmal subarachnoid hemorrhage. [9][10][11] The serum glucose/potassium ratio (GPR) is calculated as the serum glucose level divided by the serum potassium level. Its elevation has been reported to be highly associated with increasing severity and poor prognosis of certain pathological conditions, e.g., carbon monoxide poisoning.…”

Section: Introductionmentioning

confidence: 99%

Serum glucose and potassium ratio as a predictive factor for prognosis of acute intracerebral hemorrhage

Zhuang

Cai

et al. 2021

J Int Med Res

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Objective The serum glucose/potassium ratio (GPR) is a potential prognostic predictor for acute brain injury-related diseases. We calculated the serum GPR in patients with acute intracerebral hemorrhage (ICH) and explored its prognostic value for long-term prognoses and ICH severity. Methods This retrospective cohort study consecutively included 92 patients with ICH and 92 healthy controls. The National Institutes of Health Stroke Scale (NIHSS) score, Glasgow coma scale (GCS) score, and hematoma volume were used to assess severity. A modified Rankin Scale score > 2 at 90 days post-stroke was defined as a poor outcome. Results The serum GPR was significantly higher in patients than controls. The serum GPR was weakly correlated with the NIHSS score, GCS score, and hematoma volume. The serum GPR, GCS score, and hematoma volume were independently associated with poor outcomes. In the receiver operating characteristic curve analysis, the serum GPR remarkably discriminated patients at risk of poor outcomes at 90 days. The serum GPR significantly improved the prognostic predictive capability of hematoma volume and tended to increase that of the GCS score. Conclusion Serum GPR is an easily obtained clinical variable for predicting clinical outcomes after ICH.

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Serum glucose/potassium ratio as a clinical risk factor for aneurysmal subarachnoid hemorrhage

Abstract: In this study, the serum glucose/potassium ratio of patients with aneurysmal SAH at admission was significantly correlated with H-K grade and GOS score at discharge. Therefore, this ratio was useful for predicting prognosis of aneurysmal SAH, especially in severe cases.

Cited by 42 publications

References 33 publications

Association of Plasma Glucose to Potassium Ratio and Mortality After Aneurysmal Subarachnoid Hemorrhage

Association of Plasma Glucose to Potassium Ratio and Mortality After Aneurysmal Subarachnoid Hemorrhage

Assessment of serum glucose/potassium ratio as a predictor for delayed neuropsychiatric syndrome of carbon monoxide poisoning

Serum glucose and potassium ratio as a predictive factor for prognosis of acute intracerebral hemorrhage

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