Serum glucose and lipid levels in adult congenital heart disease patients

Martínez‐Quintana, Efrén; Rodríguez‐González, Fayna; Nieto-Lago, Vicente; Nóvoa, Francisco J.; López-Ríos, Laura; Riaño-Ruiz, Marta

doi:10.1016/j.metabol.2010.03.014

Cited by 33 publications

(27 citation statements)

References 27 publications

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“…Accordingly, we further identified elevated risk of metabolic derangements in ACHD patients, consistent with decreased insulin sensitivity. These study results conform to previously published findings of abnormal glucose tolerance and low high‐density lipoprotein levels in ACHD patients 19, 20. Ohuchi et al reported lower fasting but higher postprandial blood glucose and glycated hemoglobin levels in adult Japanese who had no repair or Fontan patients compared with healthy controls 20.…”

Section: Discussionsupporting

confidence: 92%

Metabolic Syndrome in Adults With Congenital Heart Disease

Deen

Krieger

Slee

et al. 2016

JAHA

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BackgroundMetabolic syndrome increases risk for atherosclerotic coronary artery disease, and its prevalence increases with increasing age and body mass index. Adults with congenital heart disease (ACHD) are now living longer and accruing coronary artery disease risk factors. However, the prevalence of metabolic syndrome in ACHD patients is unknown.Methods and ResultsWe conducted a retrospective cohort study of ACHD patients at our center to quantify the prevalence of metabolic syndrome in an ACHD population. Using case‐control matching, we constructed a comparable control group from a population‐based sample of 150 104 adults. International Diabetes Federation criteria were used to define metabolic syndrome. We used logistic regression to compare the risk of metabolic syndrome across the resulting cohorts, which were composed of 448 ACHD patients and 448 controls matched by age and sex. Mean age of both groups was 32.4±11.3 years, and 51.3% were female. Obesity was present in 16.1% of the ACHD patients and 16.7% of the controls. Metabolic syndrome was more common in ACHD patients than in controls (15.0% versus 7.4%; odds ratio 1.82, 95% CI 1.25–2.65).ConclusionsOur data suggest that metabolic syndrome is more common among adults with congenital heart disease than in the general population. Thus, patients with congenital heart disease should be screened for metabolic syndrome and risk factors mitigated where possible to prevent atherosclerotic coronary artery disease. Preventive cardiology should be included during routine ACHD care.

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Section: Discussionsupporting

confidence: 92%

Metabolic Syndrome in Adults With Congenital Heart Disease

Deen

Krieger

Slee

et al. 2016

JAHA

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“…Hyperlipidemia has been noted in surgically corrected ACHD patients but lower cholesterol is often seen in palliated or unrepaired CHD patients who remain cyanotic. 19,20 Almost 10% of patients in this series met criteria for metabolic syndrome 12,13 , and others have reported their prevalence of metabolic syndrome to be 1.5 times higher in ACHD patients than in health controls. 21 Based upon these findings, it appears prudent to consider at least guideline-based screening and management of ASCVD risk factors in the CHD population.…”

Section: Discussionmentioning

confidence: 63%

Risk Estimates for Atherosclerotic Cardiovascular Disease in Adults With Congenital Heart Disease

Lui

Rogers

Ding

et al. 2017

The American Journal of Cardiology

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The adult with congenital heart disease (CHD) is at risk of developing atherosclerotic cardiovascular disease (ASCVD). We performed a cross-sectional study to describe established ASCVD risk factors and estimate 10-year and lifetime risk of ASCVD in adults over age 18 with CHD of moderate or great complexity using three validated risk assessment tools—the Framingham Study Cardiovascular Disease Risk Assessment, the Reynolds Risk Score, and the Atherosclerotic Cardiovascular Disease (ASCVD) Risk Estimator. We obtained extensive clinical and survey data on 178 enrolled patients, with average age 37.1±12.6 years, 51% men. At least one modifiable ASCVD risk factor was present in 70%; the two most common were overweight/obesity (53%) and systemic hypertension (24%). Laboratory data was available in 103 of the 178 patients. Abnormal levels of glycated hemoglobin, high-sensitivity C-reactive protein, and high-density lipoprotein (HDL) were each found in around 30% of patients. The 10-year ASCVD predicted risk using all three tools was relatively low (i.e., at least 90% of patients <10% risk), yet the median estimated lifetime risk was 36%. In conclusion, ASCVD risk factors are prevalent in adults with CHD. The risk estimation tools suggest that this population is particularly vulnerable to ASCVD with aging and should undergo guideline-based screening and management of modifiable risk factors.

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“…The presence of higher hypertensive patients in the moderate group compared to those in mild and severe is referred to aortic coarctation. 14,25,26 In the context of longterm outcome, these results are encouraging to some extent, since recent data indicated that the metabolic syndrome is more common among adults with CHD than in the general population, 5 especially in those with central obesity. 14,25,26 In the context of longterm outcome, these results are encouraging to some extent, since recent data indicated that the metabolic syndrome is more common among adults with CHD than in the general population, 5 especially in those with central obesity.…”

Section: Other Cardiovascular Risk Factors In Achd Patientsmentioning

confidence: 80%

Body mass index in adults with congenital heart disease

Zaqout

Vandekerckhove

Michels

et al. 2019

Congenital Heart Disease

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Objective To investigate the status of body mass index (BMI) in adult people with congenital heart disease (ACHD). Methods Five hundred thirty‐nine adults with CHD (53.8% men) were seen in the outpatient clinic from 2013 to 2015 and compared to a reference population (n = 1737). The severity of CHD was categorized as mild, moderate, and severe according to standard guidelines. Patients were categorized based on BMI as underweight (<18.5), overweight (25‐30), or obese (>30). Echocardiography and magnetic resonance imaging were used to measure ventricular function while exercise capacity was estimated via cardiopulmonary exercise test. Results Adults with CHD had slightly lower BMI than the reference group (24.1 ± 4.3 vs 24.6 ± 4.3; P = .012). Men in the mild and severe group (23.9 ± 3.6; 23.3 ± 4.4 vs 25.1 ± 3.7; P = .007; P = .023) and women in the severe group (21.6 ± 3.3 vs 24.2 ± 4.7; P < .001) had lower BMI compared to the reference group. In the subgroups, men with ventricular septal defect, coarctation of aorta/ventricular septal defect and Fontan circulation and women with Fontan circulation had lower BMI than the reference group. Underweight was more prevalent in women with severe lesions compared to the reference group (22.2% vs 3.8%; P < .001). BMI was associated with age and exercise capacity in patients with mild and moderate lesions, while higher BMI was related to better ventricular function in women with Fontan circulation. Conclusion Underweight was more prevalent in ACHD patients with severe lesions. Special attention should be paid to the possible existence of underweight‐related comorbidities.

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Serum glucose and lipid levels in adult congenital heart disease patients

Cited by 33 publications

References 27 publications

Metabolic Syndrome in Adults With Congenital Heart Disease

Metabolic Syndrome in Adults With Congenital Heart Disease

Risk Estimates for Atherosclerotic Cardiovascular Disease in Adults With Congenital Heart Disease

Body mass index in adults with congenital heart disease

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