Serum Ghrelin Level and TNF-α/Ghrelin Ratio in Patients with Previous Myocardial Infarction

Vörös, Krisztián; Prohászka, Zoltán; Kaszás, Edit; Alliquander, Anna; Terebesy, András; Horváth, Ferenc; Janik, L.; Sima, Ágnes; Forrai, Judit; Cseh, Károly; Kopper, László

doi:10.1016/j.arcmed.2012.09.002

Cited by 10 publications

(10 citation statements)

References 43 publications

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“…In agreement with our study, Kanbay et al have found abnormal serum levels of FA in the early course of CAD in a young group with mild-to-moderate kidney function alteration, suggesting that there is an independent biomarker for CAD development [35]. However, there were also some studies demonstrating the relationship of high level of FA and the development of CVD [26, 36]. The possible mechanisms lied in the fact that FA could promote atherosclerosis in CVD patients through insulin resistance induction and promote the expression of cytokine in monocytes to participate in the inflammation [10].…”

Section: Discussionsupporting

confidence: 91%

Serum Fetuin-A Levels in Patients with Cardiovascular Disease: A Meta-Analysis

Sun

Xie

Guo

et al. 2014

BioMed Research International

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Background. Fetuin-A (FA) suppresses arterial calcification, promotes insulin resistance, and appears to be elevated in patients with cardiovascular diseases (CVD), but the data is still inconsistent. To clarify the correlation between serum FA levels and the presence and severity of CVDs, we performed this meta-analysis. Method. Potential relevant studies were identified covering the following databases: PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases. Data from eligible studies were extracted and included in the meta-analysis using a random-effects model. Results. Ten case-control studies, including 1,281 patients with CVDs and 2,663 healthy controls, were included. The results showed significant differences in serum levels of FA between the CVDs patients and the healthy controls (SMD = 1.36, 95%CI: 0.37–2.36, P = 0.007). Ethnicity-subgroup analysis implied that low serum FA levels are related to CVDs in Caucasians (SMD = 1.73, 95%CI: 0.20–3.26, P = 0.026), but not in Asians (SMD = 1.04, 95%CI: −0.33–2.40, P = 0.138). Conclusion. The data indicated that decreased serum FA level is correlated with the development of CVDs. FA might be clinically valuable for reflecting the progression of CVDs.

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Section: Discussionsupporting

confidence: 91%

Serum Fetuin-A Levels in Patients with Cardiovascular Disease: A Meta-Analysis

Sun

Xie

Guo

et al. 2014

BioMed Research International

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“…Conversely, the immunosensor prepared with 2 µg/mL anti‐GHRL provided smaller currents and a lower slope but, in this case, the linear range extended from a GHRL concentration as low as 10 −6 µg/mL. Such behavior makes the immunosensor prepared with the lower anti‐GHRL concentration more suitable for the determination of GHRL in clinical samples, since, as it has been mentioned above, normal levels of the hormone are around few hundred pg/mL 9,10. Using these experimental conditions, the incubation step was found to provide optimal results when it was carried out at 37 °C for 60 min (results not shown).…”

Section: Resultsmentioning

confidence: 82%

“…The EC 50 value, which is the GHRL concentration corresponding to a fifty per cent competition, was 2.4±1.5 ng/mL, and the Hill slope, h, at the inflection point of the sigmoid curve was −0.36±0.08. The range of linearity ( r =0.994) was found to be between 10 −3 and 10 3 ng/mL which is adequate for the analysis of clinical samples 9,10.…”

Section: Resultsmentioning

confidence: 84%

“…Two forms, acylated and unacylated ghrelin, are present in blood serum 7, but only the acylated form binds with the receptor (GHSR‐1a) to activate the release of growth hormone 8. Normal levels of total GHRL in human serum are around few hundred pg/mL 9,10 with the deacylated form being clearly predominant 11. The effects of ghrelin on food intake are thoroughly investigated 12.…”

Section: Introductionmentioning

confidence: 99%

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Electrochemical Immunosensor for the Determination of Total Ghrelin Hormone in Saliva

et al. 2015

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An electrochemical immunosensor for ghrelin (GHRL) determination in saliva is reported. Anti‐GHRL was immobilized onto Protein G‐magnetic beads and a competitive immunoassay involving biotinylated GHRL and alkaline phosphatase‐streptavidin was implemented. Once conjugate was magnetically captured on a screen‐printed carbon electrode, GHRL quantization was accomplished by DPV of 1‐naphtol formed upon addition of 1‐naphtyl phosphate. A linear range between 10−3 and 103 ng/mL GHRL, and a LOD of 7 pg/mL, much smaller than those from commercial ELISA kits, were found. The usefulness of the immunosensor was demonstrated by analyzing human saliva spiked with GHRL at 0.01, 0.1, 1 and 10 ng/mL.

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“…Ghrelin lower blood pressure through dilating arteries, decrease the sympathetic activity of the autonomous nervous system and thus lower heart rate and vassal tone. Some researchers found that ghrelin levels are decreased in patients with coronary atherosclerosis [21], hypertension [22], and metabolic syndrome [23], coronary heart disease [24], diabetic subjects with advanced carotid atherosclerosis [25]. As little literature data is available concerning ghrelin levels in elderly diabetic subjects with MCI, the aims of the study were twofold: Firstly, evaluate levels of serum ghrelin in elderly patients with T2DM with and without MCI and secondly, identify the factors (including ghrelin levels) associated with MCI in elderly patients with T2DM.…”

mentioning

confidence: 99%

Ghrelin Levels in Elderly, Diabetic Patients with Mild Cognitive Impairment

Górska-Ciebiada¹,

Cypryk²,

Borkowska³

et al. 2018

Neuropsychiatry

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Objective:The etiology of cognitive impairment in diabetes is unknown, but probably associated with many factors. One of the recent hypotheses suggests that ghrelin could be involved in cognitive impairment in diabetic patients. It has been reported that ghrelin signaling occurs in the hippocampus and improves memory and spatial learning. The aim of this study was to evaluate serum levels of ghrelin in elderly, diabetic patients with and without mild cognitive impairment (MCI) and to determine the predictors of having MCI in elderly diabetics. Methods:The cross-sectional study was conduct among 276 elderly subjects with type 2 diabetes. 87 patients with MCI and 189 controls were selected according to the criteria proposed by the MCI Working Group of the European Consortium on Alzheimer's Disease (using the Montreal Cognitive Assessment: MoCA score). Data of biochemical parameters and biomarkers were collected. The serum levels of ghrelin were assessed using ELISA kit. Results:Serum levels of ghrelin were significantly lower in patients with MCI compared to controls. In MCI patients serum ghrelin levels were positively correlated with MoCA score and negatively correlated with HbA1c and BMI. The logistic regression models revealed that variables which increased the likelihood of diagnosis of MCI in elderly diabetic patients were: lower levels of ghrelin, higher levels of HbA1c, hypertension, previous cardiovascular disease, increased number of co-morbidities, and less years of formal education. Conclusion:In summary, serum levels of ghrelin were decreased in MCI elderly diabetic patients compared to controls and associated with poor MoCA score. The results indicated that lower ghrelin levels may be a risk factor for a cognitive impairment in diabetic, elderly patients. Further prospective larger studies are needed to confirm the role of this marker in the progression to dementia.

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Serum Ghrelin Level and TNF-α/Ghrelin Ratio in Patients with Previous Myocardial Infarction

Cited by 10 publications

References 43 publications

Serum Fetuin-A Levels in Patients with Cardiovascular Disease: A Meta-Analysis

Serum Fetuin-A Levels in Patients with Cardiovascular Disease: A Meta-Analysis

Electrochemical Immunosensor for the Determination of Total Ghrelin Hormone in Saliva

Ghrelin Levels in Elderly, Diabetic Patients with Mild Cognitive Impairment

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