Serum Ghrelin as a Marker of Atrophic Body Gastritis in Patients with Parietal Cell Antibodies

Checchi, Serenella; Montanaro, Annalisa; Pasqui, L.; Ciuoli, Cristina; Cevenini, Gabriele; Sestini, Fausta; Fioravanti, Carla; Pacini, Furio

doi:10.1210/jc.2007-0988

Cited by 40 publications

(23 citation statements)

References 34 publications

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“…Ghrelin has been reported to be abnormal in other gastrointestinal diseases such as inflammatory bowel diseases (29), coeliac disease (30)(31)(32)(33) and atrophic gastritis (34)(35)(36). Thus, ghrelin seems to be involved in the pathophysiology of gastrointestinal diseases/disorders.…”

Section: Discussionmentioning

confidence: 99%

Ghrelin in patients with irritable bowel syndrome

El‐Salhy

Lillebø²,

Reinemo³

et al. 2009

Int J Mol Med

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Abstract. General gastrointestinal dysmotility occurs in patients with irritable bowel syndrome (IBS). Ghrelin seems to play an important role in regulating gastrointestinal motility. The present study was undertaken, therefore, to establish the possible role of ghrelin in the pathophysiology of IBS. Thirty-seven patients with IBS (19 had IBS-constipation and 18 IBS-diarrhoea) were included in this study. Ten healthy volunteers served as controls. After overnight fast, blood samples were drawn from patients and controls, and a gastroduodenal endoscopy was performed. Biopsies were taken from oxyntic mucosa and duodenum. Ghrelin cell density was determined by computer image analysis after immunohistochemical staining of the tissues. Total and active ghrelin were detected in tissue extracts and plasma by commercially available RIA and ELISA Kits. The density of ghrelinimmunoreactive cells in the oxyntic mucosa was significantly lower in IBS-constipation and significantly higher in IBSdiarrhoea patients than healthy controls (P<0.0001 and <0.0001, respectively). There was no statistical difference in total or active ghrelin between IBS patients and controls, regarding tissue extracts or plasma. In order to compensate for the increase and decrease in the ghrelin cell density, the synthesis and release of ghrelin may be decreased and increased in IBS-diarrhoea and IBS-constipation patients, respectively. It has been speculated that this compensatory mechanism may be subjected from time to time to fatigue with the subsequent increased and decreased synthesis and release of ghrelin in IBS-diarrhoea and IBS-constipation with a subsequent intermittent diarrhoea or constipation seen in these patients, respectively.

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Section: Discussionmentioning

confidence: 99%

Ghrelin in patients with irritable bowel syndrome

El‐Salhy

Lillebø²,

Reinemo³

et al. 2009

Int J Mol Med

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“…From the literature it can be concluded that ghrelin levels in the gastric mucosa significantly decrease with more advanced histopathological changes, especially after the atrophic gastritis stage [34,35] . It has been suggested that the level of this hormone can be considered as one of the markers of gastric mucosal change progression and, at the same time, can be one of the indications for gastroscopy.…”

Section: Discussionmentioning

confidence: 99%

Gastric ghrelin in relation to gender, stomach topographyand Helicobacter pylori in dyspeptic patients

Stec−Michalska¹,

Malicki²,

Michalski³

et al. 2009

WJG

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AIM:To investigate the level of gastric ghrelin in stomach mucosa of dyspeptic patients in relation to Helicobacter pylori (H pylori ) infection, bacterial cytotoxicity, topography and gender. METHODS:The study comprised 40 premenopausal women (19 H pylori positive) and 48 men (17 H pylori positive) with functional dyspepsia. All gastric biopsy specimens revealed normal mucosa or non-atrophic gastritis. Gastric ghrelin concentration was determined by Enzyme linked immunosorbent assay. The cagA and vacA strains of bacterial DNA were identified by multiplex polymerase chain reaction. RESULTS:In general, infection with H pylori caused an increase in gastric ghrelin level regardless of gender and stomach topography. Significantly more hormone was present in both, non-infected and H pylori positive female samples, as compared to males. The distribution of bacterial strains showed cagA (+) vacA s1m1 and cagA (-) vacA s2m2 genotypes as the most common infections in the studied population. A tendency to higher ghrelin levels was observed in less cytotoxic (cagA negative) strain-containing specimens from the antrum and corpus of both gender groups (without statistical significance). CONCLUSION: An increase in gastric ghrelin levelsat the stage of non-atrophic gastritis in H pylori positive patients, especially in those infected with cagA (-) strains, can exert a gastroprotective effect.

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“…Whereas ghrelin serum levels were reported to be low, and to be the most sensitive and specific non-invasive marker for gastric body gastritis (30), ghrelin concentration decreased in patients with autoimmune atrophic gastritis and diabetes type 1 (31). In patients with chronic atrophic gastritis acetylated ghrelin levels increased in the gastric body and fundus.…”

Section: Inflammatory and Infectious Gastrointestinal Diseasesmentioning

confidence: 97%

Ghrelin in gastrointestinal diseases and disorders: A possible role in the pathophysiology and clinical implications (Review)

El‐Salhy

2009

Int J Mol Med

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Abstract. Ghrelin is a peptide hormone, which has been isolated from the stomach. It is localized mostly in endocrine cells in the oxyntic mucosa of the stomach. Ghrelin receptors are expressed equally in all parts of the gastrointestinal tract, with a similar level of expression in the mucosal and muscle layers. This peptide hormone has several functions, the most widely known is its growth hormone (GH)-releasing effect. Ghrelin plays an important role in regulating appetite, feeding and energy metabolism. It also plays a role in mediating immune response and inflammatory processes. Ghrelin stimulates gastric motility and emptying as well as motility in the small and large intestine. Ghrelin has been reported to be affected in several gastrointestinal diseases/disorders such as inflammatory bowel disease, coeliac disease, infectious diseases, functional disorders and diabetes gastroenteropathy. This indicates that ghrelin is involved in the pathophysiology of gastrointestinal diseases/disorders. Several studies have shown that ghrelin and its antagonist are a promising tool for treatment of several gastrointestinal diseases/disorders.

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Serum Ghrelin as a Marker of Atrophic Body Gastritis in Patients with Parietal Cell Antibodies

Abstract: Our study demonstrates that ghrelin secretion is negatively affected by autoimmune gastritis, and its serum level represents the most sensitive and specific noninvasive marker for selecting patients at high risk for ABG.

Cited by 40 publications

References 34 publications

Ghrelin in patients with irritable bowel syndrome

Ghrelin in patients with irritable bowel syndrome

Gastric ghrelin in relation to gender, stomach topographyand Helicobacter pylori in dyspeptic patients

Ghrelin in gastrointestinal diseases and disorders: A possible role in the pathophysiology and clinical implications (Review)

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