Serum gastrin levels and gastroduodenal lesions in children with chronic renal failure on continuous ambulatory peritoneal dialysis

Urgancı, Nafiye; Özçelik, Gül; Kalyoncu, Derya; Gulec, Seda Geylani; Akıncı, Nurver

doi:10.1097/meg.0b013e3283543ee7

Cited by 8 publications

(7 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gastropathies are commonly found in both adults and children with chronic renal failure (CRF) or end-stage renal disease (also termed uraemic gastritis) and in the post-renal transplant period (115)(116)(117)(118). The mechanism resulting in gastritis involves elevated gastrin level, increased production of gastric acid, delayed gastric emptying, complex disorder of gastrointestinal motility, and uraemic toxicity (119).…”

Section: Other Causes Of Gastritismentioning

confidence: 99%

Helicobacter pylori‐negative Chronic Gastritis in Children

Assa

Borrelli

Broekaert

et al. 2022

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

Objectives:To systematically review the current evidence on Helicobacter pylori-negative chronic gastritis including natural history, available therapies and outcomes.Methods:Articles providing data on the prevalence, treatment or outcomes of Helicobacter pylori-negative gastritis were identified through a systematic search in the MEDLINE and EMBASE databases. All original research articles from human studies until October 31, 2021, were included.Results:A total of 54 studies were included consisted of eosinophilic gastritis (n = 9), autoimmune gastritis (n = 11), collagenous gastritis (n = 16), focally enhanced gastritis (n = 6), lymphocytic gastritis (n = 5) and other causes including idiopathic gastritis and chronic renal failure related (n = 7). Most of the included studies were either cross-sectional or longitudinal cohorts except for collagenous gastritis, which mainly included case reports and case series. The prevalence of paediatric eosinophilic gastritis ranges between 5 and 7/100,000 and patients have generally favourable outcome with 50% to 70% clinical and histological response to either corticosteroids or elimination diets. Autoimmune gastritis and collagenous gastritis are extremely rare entities, commonly present with refractory iron deficiency anaemia, while lymphocytic gastritis is relatively common (10%–45%) in children with coeliac disease. Data on treatments and outcomes of autoimmune, collagenous, and focally enhanced gastritis are lacking with limited data implying poor response to therapy in the former 2 diagnoses.Conclusions:Helicobacter pylori-negative gastritis is uncommonly reported, mainly in small cohorts, mixed adult-paediatric cohorts or as sporadic case reports. As common symptoms are not specific, thus not always result in an endoscopic evaluation, the true prevalence of these distinct disorders may be underestimated, and thus under reported.

show abstract

Section: Other Causes Of Gastritismentioning

confidence: 99%

Helicobacter pylori‐negative Chronic Gastritis in Children

Assa

Borrelli

Broekaert

et al. 2022

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

show abstract

“…It is remarkable that asymptomatic CRF patients also had findings at upper GI endoscopy. Upper GI lesions were reported in 25 to 75% of CRF patients of all ages [2][3][4][5][6][7][8]. Although underlying mechanisms were not clearly identified, hypergastrinemia, achlorhydria, and chronic use of an ulcer/gastritis predisposing medication, besides an increase in bile reflux secondary to uremia [10] and decrease in basal bicarbonate secretion of the pancreas were blamed [11].…”

Section: Discussionmentioning

confidence: 99%

“…Although it is known that the frequency of such upper gastrointestinal (GI) system diseases is higher in patients with chronic renal failure (CRF), the reason for this increase is not entirely understood. Possible causes are hypergastrinemia, achlorhydria, medication, and Helicobacter pylori (Hp) infection [1][2][3][4][5][6]. The increasing incidence of upper GI diseases in CRF is a significant cause of mortality and morbidity [2].…”

Section: Introductionmentioning

confidence: 99%

Gastroduodenal findings in pediatric late-stage chronic renal failure

Bayrak,

Volkan,

Çiçek

et al. 2021

Ann Clin Anal Med

View full text Add to dashboard Cite

Aim: In this study, we aimed to determine the characteristics of upper gastrointestinal lesions in children with end-stage chronic renal failure. Materials and Methods: Late-stage chronic renal failure (CRF) cases and healthy children who underwent endoscopy at two centers from July 2015 to September 2017 were included in this study. Patient data were collected retrospectively from medical records. Clinical characteristics, endoscopic findings, rapid urease test, Helicobacter pylori (Hp) presence, and histology were noted and compared. Hp infection is accepted as "present" if both rapid urease test and histopathology were positive. Type of gastritis (chronic active gastritis (CAG), chronic inactive gastritis (CIG), or chronic lymphocytic gastritis (CLG)) was determined by histology. Results: The CRF group (n: 43, mean age: 11.12±3.63 years, 55,8% girls) and the control group (n:492, mean age: 11.69±3.84 years, 54,1% girls) were age-and gender-matched. Abdominal pain was the most common complaint in both groups. In the CRF group, 30.2% of patients were asymptomatic. Gastropathy and ulcer at bulbus were more common in the CRF group (P<0.05). Hp infection frequency was similar between the groups (37.2% vs 33.3%, P >0,05). CAG was more common than other subtypes significantly in the CRF group than that of controls (62.8% and %44.1, respectively, P<0,05). In asymptomatic CRF patients (n:12), erosive gastritis, CAG, bulbar erosions, and Hp infection were present. Discussion: Peptic disease and CAG were frequent in the pediatric CRF patients than that of the controls. However, there was no difference in terms of Hp infection frequency. Moreover, GI pathologies were common in asymptomatic CRF patients.

show abstract

“…Hemorrhagic gastritis is infrequently encountered in children, and reported cases have documented a variety of etiologies including viral infections, oncologic infiltrates, non-steroidal anti-inflammatory drug use and hypergastrinemia, and cow's milk protein allergy (4)(5)(6). In a study of 19 children with chronic renal failure who underwent endoscopy and measurement of serum gastrin levels, hemorrhagic gastritis was the most common abnormal endoscopic finding, seen in 31.5% (6). The mucosal changes in these patients were attributed to hypergastrinemia from chronic renal failure.…”

Section: Discussionmentioning

confidence: 99%

ARPC1B Mutation Manifesting as Recurrent Hematemesis With Metaplasia

Antala¹,

Whitehead²,

Melín-Aldana³

et al. 2021

JPGN Reports

View full text Add to dashboard Cite

ARPC1B is important in the maintenance and assembly of the ARP2/3 complex. Loss of this complex due to ARPC1B mutation results in impairment of actin polymerization and subsequent defects in chemotaxis, cell migration, and DNA repair. Individuals with this rare mutation present in infancy and have abnormal innate and adaptive immune responses. They develop immune-mediated inflammatory disease with associated platelet defects, eosinophilia, rashes, and bowel disease. Recurrent gastrointestinal hemorrhage has been described in known cases. Here, we report a case with endoscopic and histologic findings in a patient with this rare mutation.

show abstract

Serum gastrin levels and gastroduodenal lesions in children with chronic renal failure on continuous ambulatory peritoneal dialysis

Cited by 8 publications

References 23 publications

Helicobacter pylori‐negative Chronic Gastritis in Children

Helicobacter pylori‐negative Chronic Gastritis in Children

Gastroduodenal findings in pediatric late-stage chronic renal failure

ARPC1B Mutation Manifesting as Recurrent Hematemesis With Metaplasia

Contact Info

Product

Resources

About