Serum Gastrin and the Antral Mucosa in Atrophic Gastritis

Abstract

seronegative for parietal cell antibody) had either a normal antrum or minimal (grade 1) antral gastritis. In contrast all but one patient without raised serum gastrin (nine seronegative and two seropositive for parietal cell antibody) had severe (grades 2-3) antral gastritis. Thus circulating gastrin levels observed in patients with gastritis and achlorhydria can be directly related to the presence or absence of antral mucosal damage.Comparison of the histological appearances of the antral mucosa with serum gastrin and parietal cell antibody status has provided a basis for the separation of two distinctive forms of atrophic gastritis.

Cow's milk intolerance with melena

“…Similar findings were found earlier in atopic children, due to food hypersensitivity (Kokkonen et al 1980). A significantly increased concentration of fasting serum gastrin indicates that low acid secretion is long-standing (Strickland et al 1971). It appears that gastric function tests are useful in this assessment.…”

Morphology of the Gastric Mucosa, Gastric Secretion and Serum Gastrin Concentration following a Test Meal

“…This result is in contrast to the observation of Strickland et al (13) in 11 corresponding patients, who had gastrin levels in the normal range. Recently, it was reported by Tatsuda and Okuda (15) that the content of extractable gastrin is reduced to about 27% in atrophic antrum mucosa.…”

“…They have been attributed to an increased number of hyperactive G cells in the antrum mucosa (4). Normal gastrin values in some of these patients, observed in the previous and the present study, were related to reduction of the antral area by the aboral progression of the atrophic gastritis from the fundus (6,9,13). Further studies with multiple antral biopsies for histological and immunofluorescent examinations are necessary to examine the number of G cells in patients with gastric atrophy and normal gastrin concen tration.…”

“…The hypergastrinemia is attributable to the interruption of the negative feedback mechanism between gastrin and hydrochloric acid (7,16,18). Normal basal levels were reported in achlorhydric patients presenting atrophic lesions of the antral mucosa (13). In contrast to fasting gastrin levels, no corresponding data are available for the gastrin response to a physiological stimulus.…”

Autoimmune Gastric Disease Chemical and Clinical Studies with Special Reference to H+, K+-ATPase

“…Hypergastrinemia is present in most cases (43, 94), conceivably because of the integrity of the antral mucosa (135,138). The loss of antral acidification,with consequent loss of inhibition of gastrin release has been implicated as the main mechanism of hypergastrinemia.…”