Serum gamma glutamyltransferase as a marker of metabolic syndrome and coronary disease likelihood in nondiabetic middle-aged and elderly adults

Onat, Altan; Hergenç, Gülay; Karabulut, Ahmet; Türkmen, Serdar; Doğan, Yüksel; Uyarel, Hüseyin; Can, Günay; Sansoy, Vedat

doi:10.1016/j.ypmed.2006.04.005

Cited by 41 publications

(31 citation statements)

References 10 publications

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“…2,8,20 Moreover several epidemiological studies have demonstrated that GGT is a risk factor for CVD. [1][2]20,21 Recently, Ruttmann et al 1 showed that GGT activity was independently associated with cardiovascular mortality; indeed these findings in a large unselected cohort confirmed an association of progressive increase in GGT activity with overall mortality and cardiovascular events. Additionally, GGT was significantly correlated with several components of the metabolic syndrome, although waist circumference was not measured.…”

Section: Discussionmentioning

confidence: 99%

Elevated Gamma-Glutamyltransferase Activity and Perturbed Thiol Profile Are Associated With Features of Metabolic Syndrome

Giral

Jacob

Dourmap

et al. 2008

ATVB

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Background-Prospective cohort studies have revealed that plasma ␥-glutamyltransferase (GGT) activity exhibits a positive association with coronary artery disease. GGT which is equally elevated in metabolic syndrome (MS), is the major regulator of circulating concentrations of thiol compounds derived from glutathione (GSH) cleavage, ie, cysteine and cysteinyl glycine. We compared the circulating thiol profile in a cohort of patients displaying atherogenic dyslipidemia with and without MS. Methods and Results-This cross-sectional study involved 1131 dyslipidemic patients in primary prevention of whom 26% presented with MS. GGT activity and plasma cysteinyl-glycine and cysteine concentrations were higher in MS patients; by contrast, levels of GSH were significantly lower (PϽ10 to 4 for all comparisons versus patients without MS). We compared patient groups on the basis of the number of MS criteria which were concomitantly present. A progressive decrease in glutathione levels in contrast to a progressive increase in both cysteinyl-glycine and cysteine levels, and GGT activity, was observed as a function of the number of MS components in the overall population (P for trend Ͻ10

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Section: Discussionmentioning

confidence: 99%

Elevated Gamma-Glutamyltransferase Activity and Perturbed Thiol Profile Are Associated With Features of Metabolic Syndrome

Giral

Jacob

Dourmap

et al. 2008

ATVB

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“…14,15 However, the relation of GGT levels with severity of coronary artery disease had not been investigated previously.…”

Section: Importance Of Ggt Activity In Atherosclerosismentioning

confidence: 99%

The Importance of Gamma‐Glutamyltransferase Activity in Patients with Coronary Artery Disease

Demircan

Yazıcı

Durna

et al. 2009

Clinical Cardiology

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Background: In this study, we sought to investigate the relation of gamma-glutamyltransferase (GGT) levels with the significance of coronary artery disease (CAD), clinical presentation, left ventricular (LV) function, and inflammatory activity. Methods: A total of 235 patients (mean age: 60.1 ± 10.5 years, 166 [70%] males) who had coronary angiography were included in the study. Patients who had CAD constituted the study group (Group 1, n = 189) and patients who had insignificant coronary disease or normal coronary activity constituted the control group (Group 2, n = 46). Results: GGT levels were higher in Group 1 than Group 2 (38.7 ± 30.9 U/L versus 27.5 ± 17.5 U/L, p = 0.025). Left ventricular ejection fraction (LVEF) was lower in Group 1 than Group 2 (52.6%±11.7% versus 58.8%±11.3%, p<0.002). GGT activity (40.2 ± 32.5 U/L versus 29.1 ± 18.3 U/L, p<0.002) and c-reactive protein (CRP) levels (33.9 ± 43.6 mg/dl versus 17.8 ± 29.8 mg/dl, p<0.002) were higher, LVEF (52.6%±12.1% versus 56.5%±11.0%, p = 0.021) was lower in patients with acute coronary syndrome compared with stable CAD group. In regression analysis, CRP levels (p<0.0001, odds ratio [OR] = 3.77, 95% confidence interval [CI] 0.10

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“…Serum GGT level has also been associated with many cardiovascular disease risk factors and the metabolic syndrome [2,10,11], as well as with insulin resistance in non-alcohol drinkers [9,12].…”

Section: Introductionmentioning

confidence: 99%

Association of serum γ‐glutamyltransferase and alanine aminotransferase activities with risk of type 2 diabetes mellitus independent of fatty liver

Kim

Park

Lee

et al. 2008

Diabetes Metabolism Res

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Serum gamma glutamyltransferase as a marker of metabolic syndrome and coronary disease likelihood in nondiabetic middle-aged and elderly adults

Cited by 41 publications

References 10 publications

Elevated Gamma-Glutamyltransferase Activity and Perturbed Thiol Profile Are Associated With Features of Metabolic Syndrome

Elevated Gamma-Glutamyltransferase Activity and Perturbed Thiol Profile Are Associated With Features of Metabolic Syndrome

The Importance of Gamma‐Glutamyltransferase Activity in Patients with Coronary Artery Disease

Association of serum γ‐glutamyltransferase and alanine aminotransferase activities with risk of type 2 diabetes mellitus independent of fatty liver

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