Serum gamma-glutamyl transpeptidase as a diagnostic aid in problem drinkers

Reyes, Edward; Miller, William R.

doi:10.1016/0306-4603(80)90022-2

Cited by 31 publications

(7 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The levels of GGT, SGOT, and HDLc (high-density lipoproteins cholesterol) were also determined at various follow-up points to be used as potential corroborators of self-reported drinking. These tests of liver function have been shown to be sensitive to levels of reported alcohol consumption (Castelli et al, 1977;Pomerleau et al, 1978;Reyes & Miller, 1980).…”

Section: Follow-up Assessmentsmentioning

confidence: 99%

Random assignment to abstinence and controlled drinking: Evaluation of a cognitive-behavioral program for problem drinkers.

Sanchez‐Craig¹,

Annis²,

Bronet³

et al. 1984

Journal of Consulting and Clinical Psychology

206

View full text Add to dashboard Cite

A cognitive-behavioral program with a goal of either abstinence or controlled drinking was assessed. The 70 early-stage problem drinkers were randomly assigned to one of the two goal conditions, and within each condition to one of two therapists. On average they received six individual weekly sessions, each lasting approximately 90 min. Both groups were taught to indentify risk situations and existing competencies, to develop cognitive and behavioral coping, and to assess their progress objectively. The controlled-drinking group was also taught procedures for moderate drinking. Over the 2-year follow-up period, no significant differences were found between the groups in reported alcohol consumption. Six months after treatment drinking had been reduced from an average of about 51 drinks per week to 13, and this reduction was maintained throughout the second year. Reports of drinking were corroborated by independent measures. Although the outcomes of the groups were similar, controlled drinking was considered to be a more suitable goal; it was more acceptable to the majority of the clients, and most of those assigned to abstinence developed moderate drinking on their own. The authors wish to thank the following colleagues for their contributions to the project: C. Milton-Feasby and V. Ittig-Deland for conducting intake and follow-up assessments, B. Sisson for medical screenings, Y. Israel for recommending the biochemical corroborators of alcohol consumption, and B. Kapur for conducting the laboratory analyses. Special appreciation is extended to H. Lei for his advice on statistical analyses and to D. A. Wilkinson, K. D. Walker, H. A. Skinner, and C. Poulos for their valuable feedback and support.Requests for reprints should be sent to M.

show abstract

Section: Follow-up Assessmentsmentioning

confidence: 99%

Random assignment to abstinence and controlled drinking: Evaluation of a cognitive-behavioral program for problem drinkers.

Sanchez‐Craig¹,

Annis²,

Bronet³

et al. 1984

Journal of Consulting and Clinical Psychology

206

View full text Add to dashboard Cite

show abstract

“…Its usefulness as a marker is based on the pharmacological effects of ethanol on the liver; hence, it shows different characteristics in the patients without liver disease as compared to those in the patients with liver disease [5]. GGT is a heterodimeric, membrane-bound glycoprotein [6] which catalyzes the transfer of the gamma glutamyl moiety of glutathione to various peptide acceptors [7]. It has been shown to play an important role in the detoxification of carcinogens and xenobiotics [8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Oxidative Stress in Chronic Alcoholics

Aggarwal¹

2013

JCDR

View full text Add to dashboard Cite

“…Chronic exposure to ethanol produces an elevation in the enzymes y-glutamyl transferase, aspartate aminotransferase, alanine aminotransferase, and glutamate dehydrogenase in the serum of humans [18,191. Among pregnant women, blood levels of y-glutamyl transferase and mean cell volume were predictive of FAS in 62% and 41%, respectively, of the cases of FAS reported by Ylikorkala et al [20], while low levels of maternal serum a-fetoprotein and pregnancyspecific fi-1-glycoprotein each predicted FAS correctly in 59% and 56'30, respectively, of the cases reported by Halmesmaki et al [21].…”

Section: Introductionmentioning

confidence: 99%

Two‐dimensional protein electrophoresis and multiple hypothesis testing to detect potential serum protein biomarkers in children with fetal alcohol syndrome

et al. 1995

Electrophoresis

View full text Add to dashboard Cite

Fetal alcohol syndrome (FAS) surveillance and intervention efforts are hampered by the lack of a specific biochemical test for diagnosis of the syndrome. Based on the hypothesis that abnormalities in growth and development (key features of FAS) involve altered protein metabolism, we analyzed serum proteins by two-dimensional gel electrophoresis and image analysis to search for potential protein biomarkers of FAS. Serum samples from 12 participants in whom FAS had been diagnosed and 8 sex- and age-matched participants whose mothers did not consume alcohol were analyzed in duplicate to determine whether the integrated intensities of matched proteins are significantly altered in children with FAS. Multiple hypothesis testing on 34 of the gels consisting of more than 1700 spots per gel revealed 21 proteins that we classified as potential protein biomarkers of FAS on the basis of significant t-test differences at p < 0.02. We classified 8 of the proteins as candidate biomarkers on the basis of significant concentration differences between case and control subjects at p < 0.01. One of the proteins is clearly an isoform of retinol binding protein; two appear in the area of the gel where alcohol dehydrogenase is expected to appear; one appears to be an isoform of alpha-1-antitrypsin; three appear to be isoforms of the beta-chain of haptoglobin; three may be forms of immunoglobulin light chains; and several others have not been associated with known proteins. No single protein differentiated all case subjects from control subjects, but stepwise canonical discriminant analyses revealed four groups of spots that distinguished between FAS case and control subjects with no misclassifications.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Serum gamma-glutamyl transpeptidase as a diagnostic aid in problem drinkers

Cited by 31 publications

References 9 publications

Random assignment to abstinence and controlled drinking: Evaluation of a cognitive-behavioral program for problem drinkers.

Random assignment to abstinence and controlled drinking: Evaluation of a cognitive-behavioral program for problem drinkers.

Evaluation of the Oxidative Stress in Chronic Alcoholics

Two‐dimensional protein electrophoresis and multiple hypothesis testing to detect potential serum protein biomarkers in children with fetal alcohol syndrome

Contact Info

Product

Resources

About