Serum Gamma-Glutamyl Transferase Level Is an Independent Predictor of Incident Hypertension in Korean Adults

Kim, Nan Hee; Huh, Jung Kwon; Kim, Byung Jin; Kim, Min Woong; Kim, Bum Soo; Kang, Jin Ho

doi:10.3109/10641963.2012.665539

Cited by 25 publications

(32 citation statements)

References 19 publications

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“…Stojakovic et al [18] found that serum GGT activity was positively associated with male gender and markers of metabolic syndrome. Clinical and prognostic impact of GGT activity has been shown in patients with diabetes mellitus and hypertension [8,19,20]. As a result, GGT activity has an important role in the pathogenesis of cardiovascular diseases and may be used as a marker of risk of cardiovascular events [21].…”

Section: Discussionmentioning

confidence: 99%

Serum gamma-glutamyl transferase levels and in-hospital mortality in patients with acute heart failure

et al. 2014

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A b s t r a c tBackground: Acute heart failure (AHF) is a major cause of hospitalisation, morbidity and mortality worldwide. Gamma-glutamyl transferase (GGT) is an enzyme responsible for the extracellular catabolism of antioxidant glutathione and a potential risk indicator of cardiac mortality. Limited data exists on the prognostic value of circulating levels of GGT in patients hospitalised due to AHF. Aim:To study the association between baseline GGT activity and in-hospital mortality in AHF patients. Methods:The study cohort consisted of 183 AHF patients with left ventricular ejection fraction (LVEF) < 50%. The primary endpoint was in-hospital mortality. Patients were divided into two groups according to in-hospital mortality. The relationship between GGT activity and in-hospital mortality was tested using logistic regression models, adjusting for clinical characteristics and echocardiographic findings. Results:After adjustment for possible confounders, GGT level was significantly related (OR 1.056, 95% CI 1.018-1.096, p = 0.04) to in-hospital mortality Conclusions: Elevated GGT activity is an independent predictor of short-term mortality in patients with AHF and reduced LVEF.

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Section: Discussionmentioning

confidence: 99%

Serum gamma-glutamyl transferase levels and in-hospital mortality in patients with acute heart failure

et al. 2014

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“…Other studies have shown that GGT correlates with systolic and diastolic blood pressure (69), arterial stiffness (69,70) or impaired aortic elasticity (71). Elevated but still within normal range GGT correlated with incident hypertension in drinkers and non-overweight subjects (72). Recent metaanalyses summarized the evidence linking elevated GGT level with the risk of arterial hypertension (73,74).…”

Section: Ggt and Arterial Hypertensionmentioning

confidence: 99%

Gamma-glutamyl transferase and cardiovascular disease

Ndrepepa¹,

Kastrati²

2016

Ann. Transl. Med.

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Gamma-glutamyl transferase (GGT) is an enzyme located on the external surface of cellular membranes. GGT contributes in maintaining the physiological concentrations of cytoplasmic glutathione and cellular defense against oxidative stress via cleavage of extracellular glutathione and increased availability of amino acids for its intracellular synthesis. Increased GGT activity is a marker of antioxidant inadequacy and increased oxidative stress. Ample evidence suggests that elevated GGT activity is associated with increased risk of cardiovascular disease (CVD) such as coronary heart disease (CHD), stroke, arterial hypertension, heart failure, cardiac arrhythmias and all-cause and CVD-related mortality. The evidence is weaker for an association between elevated GGT activity and acute ischemic events and myocardial infarction. The risk for CVD or CVD-related mortality mediated by GGT may be explained by the close correlation of GGT with conventional CVD risk factors and various comorbidities, particularly non-alcoholic fatty liver disease, alcohol consumption, oxidative stress, metabolic syndrome, insulin resistance and systemic inflammation. The finding of GGT activity in atherosclerotic plaques and correlation of intra-plaque GGT activity with histological indexes of plaque instability may suggest a participation of GGT in the pathophysiology of CVD, particularly atherosclerosis. However, whether GGT has a direct role in the pathophysiology of CVD or it is an epiphenomenon of coexisting CVD risk factors or comorbidities remains unknown and Hill's criteria of causality relationship between GGT and CVD are not fulfilled. The exploration whether GGT provides prognostic information on top of the information provided by known cardiovascular risk factors regarding the CVD or CVD-related outcome and exploration of molecular mechanisms of GGT involvement in the pathophysiology of CVD and eventual use of interventions to reduce circulating GGT activity remain a duty of future studies.

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“…Moreover, increased preload, as a result of increased blood pressure, contributes to the development of aneurysms (34). On the other hand, various findings indicate a correlation between serum GGT levels and high blood pressure (35). High serum GGT levels may be an indicator of increased oxidative stress in the patients.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the maximum serum GGT levels in patients with ascending aortic dilation implies that these patients have more oxidative stress load compared to the patients with normal aortic diameter (control group). On the other hand, since the ascending aortic dilation group includes more patients with high blood pressure, this could contribute to higher serum GGT levels and increased oxidative stress (35).…”

Section: Discussionmentioning

confidence: 99%

Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta

Demir¹,

Caglar²,

Türeli³

et al. 2014

Anadolu Kardiyol Derg

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Objective: This study aimed to evaluate the serum gamma-glutamyltransferase (GGT) levels as an indirect marker of elevated oxidative stress in patients with dilated ascending aorta. Methods: The study was designed as an observational cross-sectional controlled study. One hundred consecutive patients with dilated ascending aorta and 50 consecutive controls with normal ascending aorta diameter were selected for the study by comprehensive transthoracic echocardiography (TTE). The aortic dilatation group was divided into two subgroups, according to the literature as the ectasia group (3.8-4.3 cm, 53 patients, 24 male and 29 female, mean age: 62.9±10.9 years) and the aneurysm group (≥4.4 cm, 47 patients, 18 male and 29 female, mean age: 65.5±11.1 years). The control group consisted of patients demonstrating no ascending aorta dilatation (≤3.7 cm, 50 patients, 24 male and 26 female, mean age: 62.7±9.2 years). ANOVA, Mann-Whitney U test, Pearson's correlation analysis, multivariate logistic regression analysis, and receiver-operator curve analysis were used for statistical analysis. Results: Regarding the comparison of laboratory parameters between the patient and control groups, serum gamma-glutamyltransferase (GGT) levels were found to be statistically significantly higher in both of the aortic dilatation subgroups than in the control group (p<0.001). In the correlation analysis between the ascending aorta diameter and GGT, a statistically significant positive correlation was found (r=0.282, p<0.001). The multivariate regression analysis revealed a significant relationship between GGT and the proximal ascending aorta diameter (β=0.131, odds ratio: 1.140, 95% CI: 1.060-1.225, p<0.001). Conclusion: GGT as a marker of oxidative stress may play a role in the pathogenesis of aneurysm of the ascending aorta.

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Serum Gamma-Glutamyl Transferase Level Is an Independent Predictor of Incident Hypertension in Korean Adults

Cited by 25 publications

References 19 publications

Serum gamma-glutamyl transferase levels and in-hospital mortality in patients with acute heart failure

Serum gamma-glutamyl transferase levels and in-hospital mortality in patients with acute heart failure

Gamma-glutamyl transferase and cardiovascular disease

Elevated serum gamma-glutamyltransferase levels in patients with dilated ascending aorta

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