Serum Gamma-Glutamyl Transferase (GGT) Levels and Inflammatory Activity in Patients With Non-dipper Hypertension

Ermiş, Necip; Yağmur, Jülide; Açıkgöz, Nusret; Cansel, Mehmet; Çuğlan, Bilal; Pekdemir, Haşan; Оздемир, Рамазан

doi:10.3109/10641963.2011.577485

Cited by 17 publications

(15 citation statements)

References 22 publications

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“…Mean platelet volume, which is a determinant of platelet activation, was higher among nondippers compared to dippers (9.72 ± 0.52 fL versus 9.38 ± 0.33 fL, P < 0.05) 18. Inflammatory markers, such as c-reactive protein, were also higher among nondippers 18,19…”

Section: Association Of Nondippers With Risk Factors and Target Organmentioning

confidence: 88%

Antihypertensive therapy: nocturnal dippers and nondippers. Do we treat them differently?

Chakrapani¹,

Kamath²,

Unnikrishnan³

et al. 2013

VHRM

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Hypertension is a major independent risk factor for cardiovascular diseases. Management of hypertension is generally based on office blood pressure since it is easy to determine. Since casual blood pressure readings in the office are influenced by various factors, they do not represent basal blood pressure. Dipping of the blood pressure in the night is a normal physiological change that can be blunted by cardiovascular risk factors and the severity of hypertension. Nondipping pattern is associated with disease severity, left ventricular hypertrophy, increased proteinuria, secondary forms of hypertension, increased insulin resistance, and increased fibrinogen level. Long-term observational studies have documented increased cardiovascular events in patients with nondipping patterns. Nocturnal dipping can be improved by administering the antihypertensive medications in the night. Long-term clinical trials have shown that cardiovascular events can be reduced by achieving better dipping patterns by administering medications during the night. Identifying the dipping pattern is useful for decisions to investigate for secondary causes, initiating treatment, necessity of chronotherapy, withdrawal or reduction of unnecessary medications, and monitoring after treatment initiation. Use of this concept at the primary care level has been limited because 24-hour ambulatory blood pressure monitoring has been the only method for documenting dipping/nondipping status so far. This monitoring technique is expensive and inconvenient for routine usage. Simpler methods using home blood pressure monitoring systems are evolving to document basal blood pressure in the night, which would help in greater acceptance and use of the concept of dipper/nondipper in managing hypertension at the primary care level.

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Section: Association Of Nondippers With Risk Factors and Target Organmentioning

confidence: 88%

Antihypertensive therapy: nocturnal dippers and nondippers. Do we treat them differently?

Chakrapani¹,

Kamath²,

Unnikrishnan³

et al. 2013

VHRM

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“…The nondipper pattern is associated with an increased risk for cardiovascular, cerebrovascular, and renal complications 4,5,41 . Although the exact mechanisms of nondipping pattern have yet to be wholly elucidated, studies suggest that nondippers display impaired autonomic dysfunction, higher sympathetic activity, and higher inflammatory activity 42–45 . While the relationship between UA and hypertension is not debated, 36 currently there is no information on whether UA is related to nondipper status in essential hypertension.…”

Section: Discussionmentioning

confidence: 99%

“…4,5,41 Although the exact mechanisms of nondipping pattern have yet to be wholly elucidated, studies suggest that nondippers display impaired autonomic dysfunction, higher sympathetic activity, and higher inflammatory activity. [42][43][44][45] While the relationship between UA and hypertension is not debated, 36 currently there is no information on whether UA is related to nondipper status in essential hypertension. In our study, increased serum UA was an independent and strong predictor of nondipper hypertension.…”

Section: Discussionmentioning

confidence: 99%

Serum Uric Acid, Inflammation, and Nondipping Circadian Pattern in Essential Hypertension

Turak¹,

Özcan²,

Tok³

et al. 2012

J of Clinical Hypertension

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5Uric acid (UA) is independently associated with the emergence of hypertension. Nocturnal nondipping pattern of hypertension is associated with a greater risk of cardiovascular, renal, and cerebrovascular complications than dippers. The aim of the present study was to evaluate the relationship between the circadian blood pressure rhythm and UA level in patients with newly diagnosed essential hypertension. The study included 112 essential hypertensive patients and 50 healthy controls. The hypertensive patients were divided into two groups according to the results of 24-hour ambulatory blood pressure monitoring, including 60 dippers (35 men, 25 women; mean age, 52.6AE15.8 years) and 52 nondippers (29 men, 23 women; mean age, 55.9AE13.2 years). Nondippers had significantly higher serum UA levels than the dippers and controls (5.8AE0.8, 5.1AE0.9 and 4.2AE0.9 mg ⁄ dL, respectively; P<.001). Serum high-sensitivity C-reactive protein levels were also significantly higher in the nondipper group than the other groups (P<.001) and significantly correlated with serum UA (r=0.358, P<.001). Multivariate logistic regression analysis revealed an independent positive association between serum UA levels and nondipper pattern (odds ratio, 2.28; 95% confidence interval, 1.33-3.94; P=.003). Serum UA is strongly and independently associated with the nondipper circadian pattern in essential hypertension. J Clin Hypertens (Greenwich). 2013; 15:7-13. Ó2012 Wiley Periodicals, Inc.

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“…It has been suggested that nondippers display impaired autonomic dysfunction (17), higher sympathetic activity (18), higher inflammatory activity (19,20), prominent insulin resistance (2) and increased oxidative stress leading to endothelium-dependent vasodilation dysfunction (21). Clinical observations have shown the association of several plasma biomarkers with nondipper hypertension, including plasma atrial and brain natriuretic peptides (22) and vitamin D deficiency (23).…”

Section: Discussionmentioning

confidence: 99%

Sphingomyelin levels in nondipper and dipper hypertensive patients

Zheng

Xie

et al. 2013

Experimental and Therapeutic Medicine

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A number of studies have focused on the association between sphingomyelin (SM) levels and atherosclerosis, however, there are few data concerning the correlation of SM with nondipper hypertension. The present study aimed to investigate the correlation between plasma SM levels and nondipper status in patients with hypertension. A total of 200 hypertensive patients were enrolled and divided into two groups according to their ambulatory blood pressure monitoring (AMBP) results: Dipper group (84 patients) and nondipper group (116 patients). All patients were subjected to transthoracic echocardiography examination and laboratory tests. No statistically significant difference was observed between the two groups in terms of basic clinical characteristics. However, the plasma SM levels in the dipper group were significantly lower than those of the nondipper group (41.9±17.5 vs. 96.4±14.3 mg/dl, P=0.003). The left ventricular mass index (LVMI) was higher in the nondipper patients than in the dipper patients and the diastolic function parameters in the nondipper patients were less favorable. Correlation analysis showed that the SM level was negatively correlated with the magnitude of systolic blood pressure (SBP) fall at night (r=−0.42, P<0.01) and diastolic blood pressure (DBP) fall at night (r=−0.31, P<0.01). The nondipper status had contributory effects on hypertensive concentric hypertrophy and diastolic function impairment. In addition, the plasma SM level was associated with a nondipper pattern of hypertension.

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Serum Gamma-Glutamyl Transferase (GGT) Levels and Inflammatory Activity in Patients With Non-dipper Hypertension

Cited by 17 publications

References 22 publications

Antihypertensive therapy: nocturnal dippers and nondippers. Do we treat them differently?

Antihypertensive therapy: nocturnal dippers and nondippers. Do we treat them differently?

Serum Uric Acid, Inflammation, and Nondipping Circadian Pattern in Essential Hypertension

Sphingomyelin levels in nondipper and dipper hypertensive patients

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