Serum Galectin and Renal Dysfunction in ST-Segment Elevation Myocardial Infarction

Abstract

This study aimed to evaluate the association between serum galectin levels and renal dysfunction in relation to in-hospital prognosis and unfavorable prognosis 1 year after ST-elevated myocardial infarction (STEMI). Patients were assigned to two groups according to the cystatin C-based estimate of GFR on day 12 after STEMI: (1) STEMI patients with normal renal function (GFR based on cystatin C levels = 60 mL/min/1.73 m2) and (2) those with renal dysfunction (RD) (GFR based on cystatin C levels <60 mL/min/1.73 m2). A decrease in GFR estimated from the CKD-EPI equation on day 12 was more frequently found in patients with a reduced GFR based on cystatin C levels (41.9%) compared with those without RD (21.3%). Galectin levels exceeded the cut-off value (17.8 ng/mL) in 50.6% of cases in the group with GFR <60 mL/min/1.73 m2 and in 32% of cases in the group with a normal GFR. The presence of RD and elevated galectin levels >17.8 ng/mL on day 12 after MI are independent predictors of an adverse prognosis at 1 year in STEMI patients. Elevated galectin levels are directly correlated with the presence of early postinfarction angina.

Association of Admission Glucose Level with Arrythmia and Heart Failure in Hyperglycemic Patients with Non-ST-Segment Elevation Myocardial Infarction

“…23 Thus, elevated plasma glucose would both reflect the acute stress and predict an increased propensity for long-term cardiovascular events. 10 Several studies showed that an elevated admission blood glucose in myocardial infarction correlates with an increased incidence of congestive heart failure, cardiogenic shock, and inhospital mortality, [7][8][9][10][11][19][20][21][22] which support our findings.…”

“…Surprisingly, hyperglycemia, as determined by using a simple, low-cost laboratory test, has been associated with a worse prognosis in MI patients, even in the absence of diabetes. 7,8 Patients either with or without a prior history of diabetes mellitus may present with hyperglycemia during acute myocardial infarction. Among patients with no prior history of diabetes, hyperglycemia may reflect previously undiagnosed diabetes, preexisting carbohydrate intolerance, stressrelated carbohydrate intolerance, or a combination of these.…”

“…9,10 Several studies have reported an association between elevated blood glucose upon admission and subsequent increased adverse events, including congestive heart failure, cardiogenic shock, and death. [7][8][9][10][11] Hence, observationof admission blood glucose level in non-ST elevation myocardial infarction is also crucial.…”

Ultrasound‑targeted microbubble destruction‑mediated Galectin‑7‑siRNA promotes the homing of bone marrow mesenchymal stem cells to alleviate acute myocardial infarction in rats

“…Galectin is a novel target associated with unfavorable prognosis in patients with heart failure. Elevated galectin levels are related to heart failure, and may be a primary regulator of cardiac remodeling with myocardial fibrosis ( 13 ). Galectin-7, as a member of galectin family, plays a role in various events related to the development of the pluristratified epithelium ( 14 ).…”