Serum galectin‐3 levels and delirium among postpartum intensive care unit women

Zhu, Ying; Hu, Wei; Zhu, Mingli; Yin, Ting; Su, Jun; Wang, Jianrong

doi:10.1002/brb3.773

Cited by 12 publications

(4 citation statements)

References 40 publications

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“…A comprehensive evaluation of the titles and abstracts resulted in the exclusion of 202 studies, leaving 39 articles as potentially relevant. 12 -50 Sixty-nine articles were identified using Google Scholar, none of which were included. No additional article was identified or selected from the reference lists of the retained studies (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Biomarker Predictors of Delirium in Acutely Ill Patients: A Systematic Review

Michels¹,

Michelon²,

Damasio³

et al. 2019

J Geriatr Psychiatry Neurol

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Delirium is a serious and common disorder that affects up to 80% of acutely ill patients, mainly the aged. In recent years, several studies pointed out possible biomarkers that could be used alone or in combination with other resources in the diagnosis and follow-up of critically ill patients who develop delirium. In this context, a systematic review was conducted to determine the predictive value of several biomarkers in acutely (critically and noncritically) ill adult patients with delirium. Studies that used the confusion assessment method (CAM) and CAM-intensive care unit as the diagnostic method were considered. The most recent search was performed in November 2017. There was no language restriction. Initially, 626 articles were screened and 39 were included in the study. A comprehensive evaluation of the abstracts resulted in the exclusion of 202 studies, leaving 39 articles as potentially relevant. Inflammatory markers, S100b and cortisol, could predict delirium occurrence in a specific subgroup population of critically ill patients.

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Section: Resultsmentioning

confidence: 99%

Biomarker Predictors of Delirium in Acutely Ill Patients: A Systematic Review

Michels¹,

Michelon²,

Damasio³

et al. 2019

J Geriatr Psychiatry Neurol

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“…The galectin-3 protein is involved in the phagocytic process of apoptotic hepatocytes [40]. Galectin-3 is one of the most frequently identified markers of liver disease [41] and is considered a prognostic biomarker in severe trauma or sepsis patients [42][43][44]. These findings indicated that hepatic inflammation and injury were attenuated when Arg was administered after CLP.…”

Section: Discussionmentioning

confidence: 97%

Intravenous Arginine Administration Benefits CD4+ T-Cell Homeostasis and Attenuates Liver Inflammation in Mice with Polymicrobial Sepsis

Yeh

Tanuseputero

et al. 2020

Nutrients

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This study investigated the effects of a single dose of arginine (Arg) administration at the beginning of sepsis on CD4+ T-cell regulation and liver inflammation in C57BL/6J mice. Mice were divided into normal control (NC), sham (SH), sepsis saline (SS), and sepsis Arg (SA) groups. An inducible nitric oxide (NO) synthase (iNOS) inhibitor was administered to additional sepsis groups to evaluate the role of NO during sepsis. Sepsis was induced using cecal ligation and puncture (CLP). The SS and SA groups received saline or Arg (300 mg/kg body weight) via tail vein 1 h after CLP. Mice were euthanized at 12 and 24 h post-CLP. Blood, para-aortic lymph nodes, and liver tissues were collected for further measurement. The findings showed that sepsis resulted in decreases in blood and para-aortic lymph node CD4+ T-cell percentages, whereas percentages of interleukin (IL)-4- and IL-17-expressing CD4+ T cells were upregulated. Compared to the SS group, Arg administration resulted in maintained circulating and para-aortic lymph node CD4+ T cells, an increased Th1/Th2 ratio, and a reduced Th17/Treg ratio post-CLP. In addition, levels of plasma liver injury markers and expression of inflammatory genes in liver decreased. These results suggest that a single dose of Arg administered after CLP increased Arg availability, sustained CD4+ T-cell populations, elicited more-balanced Th1/Th2/Th17/Treg polarization in the circulation and the para-aortic lymph nodes, and attenuated liver inflammation in sepsis. The favorable effects of Arg were abrogated when an iNOS inhibitor was administered, which indicated that NO may be participated in regulating the homeostasis of Th/Treg cells and subsequent liver inflammation during sepsis.

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“…Dillon et al showed an association between levels of an inflammatory marker, C-reactive protein (CRP), and delirium (Dillon et al, 2017 ), and they also reported that the duration and severity of delirium can be predicted by high CRP levels (Vasunilashorn et al, 2017 ). Other groups reported associations of delirium with high levels of Galectin-3 and CRP among women in postpartum intensive care units (Zhu et al, 2017 ). A pro-inflammatory cytokine, IL-6, was elevated after surgery among patients with delirium compared to controls (Liu et al, 2013 ; Vasunilashorn et al, 2015 ).…”

Section: Introductionmentioning

confidence: 97%

Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging

Shinozaki

Braun

Hing

et al. 2018

Front. Aging Neurosci.

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Background: Delirium in elderly patients is common and dangerous. Major risk factors include aging and exogenous insults, such as infection or surgery. In animal models, aging enhances pro-inflammatory cytokine release from microglia in response to exogenous insults. The epigenetic mechanism DNA methylation (DNAm) regulates gene expression and changes with age. Older individuals may have methylation changes that influence the increased cytokine upon insult, but the degree to which aging affects DNAm of cytokine genes is not fully understood.Methods: The relationship between DNAm and aging of pro-inflammatory cytokine genes (TNF-alpha, IL1-beta, IL-6) was investigated using methylation array data in two cohorts. Brain and blood samples were collected from a neurosurgery cohort (NSG) of 21 subjects who underwent brain resection. A second cohort, the Grady Trauma Project (GTP), included blood samples from 265 subjects.Results: In the NSG cohort, a significant negative correlation between age and DNAm in brain was found at a CpG in IL-6. With the GTP dataset, significant negative correlations between age and DNAm were seen at most of the CpGs in TNF-alpha. Also, TNF-Alpha expression increases with age. These GTP DNAm correlations were also nominally significant in NSG blood samples. In neuronal negative NSG brain tissue, a similar negative trend was observed.Conclusions: With aging, a decrease in DNAm of cytokines gene CpGs in glia and blood was seen. As this can affect their expression, additional research is needed to fully elucidate the role of DNAm in aging and how it may influence the pathogenesis of delirium.

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Serum galectin‐3 levels and delirium among postpartum intensive care unit women

Cited by 12 publications

References 40 publications

Biomarker Predictors of Delirium in Acutely Ill Patients: A Systematic Review

Biomarker Predictors of Delirium in Acutely Ill Patients: A Systematic Review

Intravenous Arginine Administration Benefits CD4+ T-Cell Homeostasis and Attenuates Liver Inflammation in Mice with Polymicrobial Sepsis

Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging

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