Serum free thyroxine concentration is not reduced in premature infants with respiratory distress syndrome

Job, Leela; Emery, Janet R.; Hopper, Andrew; Deming, Douglas; Nystrom, Gerald A.; Clark, Sudan J.; Nelson, Jerald C.

doi:10.1016/s0022-3476(97)80087-x

Cited by 17 publications

(7 citation statements)

References 18 publications

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“…In premature infants with IRDS normal free T 4 and TSH levels have been demonstrated suggesting normal function of the hypophyseal-thyroid axis [14]. The lack of a significant TSH response to decreased free T 4 levels in our infants may indicate persistent immaturity of the hypothalamic-pituitary axis.…”

Section: Discussionmentioning

confidence: 50%

“…In developing CLD, pneumocyte proliferation and surfactant synthesis may require larger amounts of thyroid hormones than in healthy individuals. In IRDS of preterm infants, hypothyroxinemia does not seem to be an etiological factor [14,23]. Recently Job et al [14] have demonstrated unaltered free T 4 levels in IRDS between day 2 and day 7.…”

Section: Discussionmentioning

confidence: 93%

“…In IRDS of preterm infants, hypothyroxinemia does not seem to be an etiological factor [14,23]. Recently Job et al [14] have demonstrated unaltered free T 4 levels in IRDS between day 2 and day 7. Van Wassenaer et al [15] found no beneficial effect of T 4 supplementation on pulmonary outcome.…”

Section: Discussionmentioning

confidence: 93%

“…Thyroid function has been shown to be altered significantly with depressed free T 4 levels in neonatal disease [2,3,13]. Other studies reported no influence of infant respiratory distress syndrome (IRDS) [14] or found a considerable effect of gestational age on thyroid function [15]. In chronic lung disease of prematurity (CLD), metabolism is characterized by a catabolic state and elevated energy expenditure.…”

Section: Introductionmentioning

confidence: 99%

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Thyroid Function in Healthy and Sick Very-Low-Birth-Weight Infants – Thyrotropin and Free Thyroxine Levels until the Sixth Week of Age

et al. 2001

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Hypothyroxinemia in preterm infants without congenital hypothyroidism is associated with developmental delay. Longitudinal information on thyroid function in very-low-birth-weight (VLBW, <1,500 g birth weight) infants is limited: we present data on thyroid function in sick and healthy VLBW infants until 6 weeks of age. Free T₄ and TSH levels routinely obtained on days 14–21 and days 35–49 in 92 consecutive VLBW infants were correlated retrospectively with neonatal morbidity. Free T₄ levels were positively correlated with gestational age; an independent effect of neonatal disease on thyroid function was not detectable.

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Thyroid Function in Healthy and Sick Very-Low-Birth-Weight Infants – Thyrotropin and Free Thyroxine Levels until the Sixth Week of Age

et al. 2001

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“…However, several studies have shown that fT4 levels in preterm infants are merely a function of gestational age rather than of illnesses, such as sepsis or the respiratory distress syndrome (25,26) , which reduces the necessity for statistical correction for a body of perinatal variables. First, the relatively small number of participants increases the likelihood of chance fi ndings.…”

Section: Discussionmentioning

confidence: 99%

Normal thyroid function in young adults who were born very preterm

Mollee

Finken²,

Weissenbruch³

et al. 2011

Journal of Pediatric Endocrinology and Metabolism

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There is some evidence for elevated thyrotropin (TSH) levels in children born preterm, but follow-up studies into adulthood are lacking. We tested whether thyroid function in young adults born at a gestational age < 32 weeks, with either an appropriate (appropriate for gestational age, AGA) or low birth weight for gestational age (small for gestational age, SGA), differed from that in age-matched controls. We made our measurements when the study participants reached 21 years of age. Serum concentrations of TSH and free T4 (fT4) and body composition were measured in subjects born preterm and AGA (n = 29) or SGA (n = 28), and in non-preterm controls (n = 30). The TSH and fT4 concentrations of participants were within normal limits. Free T4 levels in subjects born preterm were slightly higher than those in controls: 17.0 ± 2.4 (AGA) and 17.2 ± 1.7 (SGA) vs. 16.1 ± 1.9 pmol/L (p = 0.04). TSH concentrations did not differ between groups. From these preliminary data, we conclude that young adults born preterm have a normal thyroid function.

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Thyroid Disorders in Children and Adolescents

Rivkees¹

2002

Developmental Endocrinology

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Serum free thyroxine concentration is not reduced in premature infants with respiratory distress syndrome

Cited by 17 publications

References 18 publications

Thyroid Function in Healthy and Sick Very-Low-Birth-Weight Infants – Thyrotropin and Free Thyroxine Levels until the Sixth Week of Age

Thyroid Function in Healthy and Sick Very-Low-Birth-Weight Infants – Thyrotropin and Free Thyroxine Levels until the Sixth Week of Age

Normal thyroid function in young adults who were born very preterm

Thyroid Disorders in Children and Adolescents

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