Serum Fluoride and Sialic Acid Levels in Osteosarcoma

Sandhu, R. S; Lal, Harbans; Kundu, Zile Singh; Kharb, Simmi

doi:10.1007/s12011-009-8382-1

Cited by 37 publications

(27 citation statements)

References 19 publications

(22 reference statements)

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“…A study did find a link between mean fluoride levels in blood serum and increased osteosarcoma risk, but finding this association does not infer causality 52 . Mean fluoride levels in cases with other bone-forming tumours were significantly higher when compared with the control group consisting of patients with musculo-skeletal pain only.…”

Section: Discussionmentioning

confidence: 95%

Is fluoride a risk factor for bone cancer? Small area analysis of osteosarcoma and Ewing sarcoma diagnosed among 0-49-year-olds in Great Britain, 1980-2005

Blakey

Feltbower

Parslow

et al. 2014

International Journal of Epidemiology

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Background: Artificial fluoridation of drinking water to improve dental health has long been a topic of controversy. Opponents of this public health measure have cited the possibility of bone cancer induction. The study objective was to examine whether increased risk of primary bone cancer was associated with living in areas with higher concentrations of fluoride in drinking water.Methods: Case data on osteosarcoma and Ewing sarcoma, diagnosed at ages 0–49 years in Great Britain (GB) (defined here as England, Scotland and Wales) during the period 1980–2005, were obtained from population-based cancer registries. Data on fluoride levels in drinking water in England and Wales were accessed through regional water companies and the Drinking Water Inspectorate. Scottish Water provided data for Scotland. Negative binomial regression was used to examine the relationship between incidence rates and level of fluoride in drinking water at small area level.Results: The study analysed 2566 osteosarcoma and 1650 Ewing sarcoma cases. There was no evidence of an association between osteosarcoma risk and fluoride in drinking water [relative risk (RR) per one part per million increase in the level of fluoride = 1·001; 90% confidence interval (CI) 0·871, 1·151] and similarly there was no association for Ewing sarcoma (RR = 0·929; 90% CI 0·773, 1·115).Conclusions: The findings from this study provide no evidence that higher levels of fluoride (whether natural or artificial) in drinking water in GB lead to greater risk of either osteosarcoma or Ewing sarcoma.

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Section: Discussionmentioning

confidence: 95%

Is fluoride a risk factor for bone cancer? Small area analysis of osteosarcoma and Ewing sarcoma diagnosed among 0-49-year-olds in Great Britain, 1980-2005

Blakey

Feltbower

Parslow

et al. 2014

International Journal of Epidemiology

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“…They found that, compared to control groups, serum sialic acid concentration was significantly increased in patients with osteosarcoma and, in a second study, in patients with other bone tumors (Sandhu et al, 2011). …”

Section: Osteosarcomamentioning

confidence: 93%

“…Based on the concept that glycoproteins and glycosaminoglycans are an integral part of bone and prolonged exposure to fluoride for long duration has been shown to cause degradation of collagen and ground substance in bones, Sandhu et al (2011) analyzed serum fluoride, sialic acid, calcium, phosphorus, and ALP levels in patients with osteosarcoma. They found that, compared to control groups, serum sialic acid concentration was significantly increased in patients with osteosarcoma and, in a second study, in patients with other bone tumors (Sandhu et al, 2011).…”

Section: Osteosarcomamentioning

confidence: 99%

Biomarkers of Osteosarcoma, Chondrosarcoma, and Ewing Sarcoma

et al. 2017

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Osteosarcoma is the most frequent malignant bone neoplasm, followed by chondrosarcoma and Ewing sarcoma. The diagnosis of bone neoplasms is generally made through histological evaluation of a biopsy. Clinical and radiological features are also important in aiding diagnosis and to complete the staging of bone cancer. In addition to these, there are several non-specific serological or specific molecular markers for bone neoplasms. In bone tumors, molecular markers increase the accuracy of the diagnosis and assist in subtyping bone tumors. Here, we review these markers and discuss their role in the diagnosis and prognosis of the three most frequent malignant bone neoplasms, namely osteosarcoma, chondrosarcoma, and Ewing sarcoma.

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“…This indicated that the human osteosarcoma cells expressed both forms of Sia-containing glycoconjugates and the differences in the amounts of each of the two major Sia types and their distribution may be related to the morphology and/or metastatic of osteosarcoma 15 . Another studies of Sia level in the serum reported that the amount of Sia in the serum of osteosarcoma patients was higher than in the control group, but did not differ from those of other bone-forming groups 16 . However, the accumulated data on the level and distribution of Sia in osteosarcoma is still limited.…”

Section: Discussionmentioning

confidence: 90%

“…A significant elevation of the total Sia level was found when compared with that level in the control sera. However, an increase of the Sia level was also found in the sera of patients with other boneforming tumours 16 . Here, to better understand the relation of elevated Sia and the pathology of osteosarcoma, osteosarcoma cells were isolated from bone samples of 7 patients with osteosarcoma.…”

Section: Introductionmentioning

confidence: 88%

Level and distribution of secreted and cell-associated N-acetyl, N-glycolylneuraminic, and deaminoneuraminic acids in osteosarcoma cells isolated from patients

Phitak¹,

Klangjorhor²,

Pothacharoen³

et al. 2017

ScienceAsia

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Sialic acids, which are members of a family of 9-carbon carboxylated sugars, usually occupy the terminal position of the glycan chains of glycoconjugates and play an important role in various biological processes. Nacetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc) are the dominant sialic acids in mammals, whereas deaminoneuraminic acids (KDN) can be detected in trace amounts. The increase of sialic acid levels has been reported in relation to the pathology and aggressiveness of cancer. Here we used a fluorometric-HPLC method to investigate the level and distribution of Neu5Ac, Neu5Gc, and KDN in osteosarcoma cells isolated from 7 patients and compare them with those in osteoblasts isolated from 3 patients with other bone diseases. Both cell types expressed all three sialic acids with abundances Neu5Ac > Neu5Gc > KDN. Total sialic acid levels in osteosarcoma cells were twice that in osteoblast cells. Only cell-associated Neu5Ac and Neu5Gc levels were higher, but not secreted forms. However, cell-associated and secreted KDN levels were not significantly different among those two groups. This suggests that the level and distribution of sialic acids in osteosarcoma cells were different from those in normal osteoblast cells. Thus their level, type, and distribution may be related to the pathology of osteosarcoma.

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Serum Fluoride and Sialic Acid Levels in Osteosarcoma

Cited by 37 publications

References 19 publications

Is fluoride a risk factor for bone cancer? Small area analysis of osteosarcoma and Ewing sarcoma diagnosed among 0-49-year-olds in Great Britain, 1980-2005

Is fluoride a risk factor for bone cancer? Small area analysis of osteosarcoma and Ewing sarcoma diagnosed among 0-49-year-olds in Great Britain, 1980-2005

Biomarkers of Osteosarcoma, Chondrosarcoma, and Ewing Sarcoma

Level and distribution of secreted and cell-associated N-acetyl, N-glycolylneuraminic, and deaminoneuraminic acids in osteosarcoma cells isolated from patients

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