Serum fibroblast growth factor-23 concentrations in young and mature adult cats with chronic kidney disease

Miyakawa, Hirosumi; Hsu, Huai-Hsun; Ogawa, Mizuki; Akabane, Ryota; Miyagawa, Yuichi; Takemura, Naoyuki

doi:10.1177/1098612x211039192

Cited by 4 publications

(17 citation statements)

References 30 publications

(49 reference statements)

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“…There was overlap in the ranges of FGF-23 concentrations between healthy cats and cats with CKD, particularly cats with stage 1 and 2 CKD, although overlap between healthy cats and cats with stage 4 CKD was reported in two publications (Figure 3). 28,32 In Geddes et al, 19 a small number of cats with stage 4 CKD had extremely high FGF-23 concentrations, with a range of 81,963 pg/ml from the first to the third quartile. No similarly dramatic FGF-23 values were reported in cats with stage 4 CKD in other studies.…”

Section: Fgf-23 and Ckd Stagementioning

confidence: 98%

Blood fibroblast growth factor 23 concentration in cats with and without chronic kidney disease: a scoping review

Summers,

Michael,

Szlosek

et al. 2024

Journal of Feline Medicine and Surgery

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Objectives This study undertook a scoping review of research on blood fibroblast growth factor 23 (FGF-23) concentrations in healthy non-azotemic cats and cats with chronic kidney disease (CKD) to describe the volume and nature of existing literature, to determine whether published studies provide adequate evidence to support the use of FGF-23 as a biomarker in clinical practice and to identify any existing gaps in knowledge. Methods PRISMA Extension for Scoping Reviews guidelines were used to design and perform the scoping review. Online databases were used to identify observational and clinical studies of blood FGF-23 concentrations in healthy cats and cats with CKD published before December 2022. Study and population characteristics and descriptive data on FGF-23 concentrations were extracted. Results A total of 205 publications were reviewed; 17 were retained for inclusion. Most studies were retrospective. Most studies included cats with International Renal Interest Society stage 2–4 CKD, with some variation. Key concepts explored in the literature include FGF-23 concentrations by CKD stage, effect of dietary phosphate restriction on FGF-23 concentrations, relationship between FGF-23 concentrations and blood phosphorus, calcium and magnesium concentrations, and FGF-23 concentrations in cats with progressive CKD. FGF-23 concentrations tended to be higher in cats with CKD compared with healthy cats, with an overlap between healthy and CKD populations, and there was significant variation within stages of CKD. Conclusions and relevance FGF-23 is a biomarker of interest for the management and monitoring of phosphate overload in cats. Studies support several potential clinical applications for measuring FGF-23 concentration in practice; however, evidence is limited. Research on FGF-23 in cats with CKD would benefit from longitudinal, prospective studies that standardize CKD diagnosis and categorize cats by stage using current guidelines. Studies should include cats with early-stage, non-azotemic CKD and use commercially available assays so such results are comparable across studies.

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Section: Fgf-23 and Ckd Stagementioning

confidence: 98%

Blood fibroblast growth factor 23 concentration in cats with and without chronic kidney disease: a scoping review

Summers,

Michael,

Szlosek

et al. 2024

Journal of Feline Medicine and Surgery

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“…Serum FGF-23 concentrations were measured using a sandwich ELISA (MedFrontier FGF23; Hitachi Chemical Diagnostics Systems) reported in a previous study. 12…”

Section: Serum Fgf-23 Concentration Assaymentioning

confidence: 99%

“…19 However, the regulation system between blood FGF-23 and calcium concentrations has not been described. 16 Based on the findings of previous studies in cats, 9,12,19 increased blood calcium concentrations can be associated with increased blood FGF-23 concentrations independently of phosphate status. In particular, in cats with upper urolithiasis, an assessment of calcium metabolism may be important, because the majority of feline ureteroliths have been reported to be composed of calcium stone.…”

Section: Introductionmentioning

confidence: 98%

“…[6][7][8] In cats, plasma concentrations of FGF-23 increase as CKD progresses. [9][10][11][12] The mechanism for elevated blood FGF-23 concentrations in patients with CKD is explained by a compensation for the accumulation of phosphate in the body, declining renal clearance of FGF-23 caused by decreased GFR and a compensatory response to decreased klotho protein in the kidney. [6][7][8][13][14][15] A number of studies have investigated the association between FGF-23 and phosphate status, [16][17][18] and in patients with CKD, phosphate accumulation in the body is thought to be an important contributor to increased blood FGF-23 concentrations.…”

Section: Introductionmentioning

confidence: 99%

“…However, previous studies demonstrated that plasma total calcium (tCa) or blood ionised calcium (iCa) concentrations were significant variables that can be used to independently predict blood FGF-23 concentrations in cats. 9,12 Furthermore, a recent study indicated that plasma FGF-23 concentrations increased significantly in cats in which plasma tCa concentration increased after the initiation of a renal diet. 19 However, the regulation system between blood FGF-23 and calcium concentrations has not been described.…”

Section: Introductionmentioning

confidence: 99%

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Association between serum fibroblast growth factor-23 concentrations and blood calcium levels in chronic kidney disease cats with upper urolithiasis

Miyakawa

Hsu

Ogawa

et al. 2022

Journal of Feline Medicine and Surgery

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Objectives This study investigated whether serum fibroblast growth factor (FGF)-23 concentrations are associated with serum total calcium (tCa) and blood ionised calcium (iCa) concentrations in cats with chronic kidney disease (CKD) and upper urolithiasis. Methods Serum samples and the medical records of cats with CKD with nephroliths, ureteroliths or both were investigated retrospectively. Cats with a serum creatinine concentration >250 μmol/l and/or a serum phosphorus concentration ⩾1.50 mmol/l were excluded. Based on cut-offs for serum tCa (2.70 mmol/l) or blood iCa (1.40 mmol/l), cats were divided into the following groups: total hypercalcaemia (H-tCa) (>2.70 mmol/l) and total normocalcaemia (N-tCa) (⩽2.70 mmol/l) groups, or ionised hypercalcaemia (H-iCa) (>1.40 mmol/l) and ionised normocalcaemia (N-iCa) (⩽1.40 mmol/l) groups, respectively. Serum FGF-23 concentrations were compared between groups and correlation analysis was performed. Results Thirty-two cats with CKD and upper urolithiasis were included. Serum FGF-23 concentrations in the H-tCa group (median 573 pg/ml [range 125–3888]; n = 12) were significantly higher compared with the N-tCa group (median 245 pg/ml [range 94–627]; n = 20) ( P = 0.001). Serum FGF-23 concentrations in the H-iCa group (median 1479 pg/ml [range 509–3888]; n = 6) increased significantly compared with the N-iCa group (median 245 pg/ml [range 94–637]; n = 26) ( P <0.001). Serum FGF-23 concentrations significantly correlated with serum tCa ( r = 0.511, P = 0.003) and blood iCa concentrations ( r = 0.425, P = 0.015) but not serum creatinine ( r = 0.279, P = 0.122) or phosphorus concentrations ( r = 0.208, P = 0.253). Conclusions and relevance Increased serum FGF-23 concentrations were associated with hypercalcaemia independently of creatinine and phosphate status in cats with CKD and upper urolithiasis.

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Nutritional Management of Kidney Disease

Queau,

Elliott

2023

Applied Veterinary Clinical Nutrition

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Serum fibroblast growth factor-23 concentrations in young and mature adult cats with chronic kidney disease

Cited by 4 publications

References 30 publications

Blood fibroblast growth factor 23 concentration in cats with and without chronic kidney disease: a scoping review

Blood fibroblast growth factor 23 concentration in cats with and without chronic kidney disease: a scoping review

Association between serum fibroblast growth factor-23 concentrations and blood calcium levels in chronic kidney disease cats with upper urolithiasis

Nutritional Management of Kidney Disease

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