Serum fibroblast growth factor 21 levels in gestational diabetes mellitus in relation to insulin resistance and dyslipidemia

Stein, Sebastian; Stepan, Holger; Kratzsch, Jürgen; Verlohren, Michael; Verlohren, Hans-Joachim; Drynda, Kathrin; Lössner, Ulrike; Blüher, Matthias; Stümvoll, Michael; Faßhauer, Mathias

doi:10.1016/j.metabol.2009.07.003

Cited by 75 publications

(57 citation statements)

References 27 publications

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“…Study of Chen et al (2008) showed a negative correlation between serum FGF21 levels and fasting plasma glucose levels. Our results are not in agreement with the findings of other studies (Eto et al, 2010;Stein et al, 2010;Chen et al, 2008). The elevation of FGF21 levels in type 2 diabetic patients may be associated with a compensatory response, FGF21 resistance (Chavez et al, 2009;Chen et al, 2011).Studies on animal models have indicated that FGF21 is expressed in the pancreas (Tacer et al, 2010) to protect the mass and function of pancreatic beta-cells (Wente et al, 2006).…”

Section: Discussioncontrasting

confidence: 95%

“…This means that FGF21 may has no effect on glucose metabolism which is especially important in type 2 diabetic subjects. The serum FGF21 levels were significantly higher in diabetic subjects with metabolic syndrome and correlated negatively with HDL cholesterol (Zhang et al, 2008;Li et al, 2009), while some other studies showed that serum FGF21 level was associated with triglycerides (Eto et al, 2010;Stein et al, 2010). Study of Chen et al (2008) showed a negative correlation between serum FGF21 levels and fasting plasma glucose levels.…”

Section: Discussionmentioning

confidence: 89%

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Serum Level of Fibroblast Growth Factor 21 in Type 2 Diabetic Patients with and without Metabolic Syndrome

Shafaei¹,

Khoshnia²,

Marjani³

2015

J. of Medical Sciences

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Effect of FGF21 on metabolic syndrome patients is not exactly clear. In the present study, we assessed serum level of fibroblast growth factor 21 in type 2 diabetic patients with and without metabolic syndrome in Gorgan. The study groups consisted of 120 patients with type 2 diabetes and 60 healthy subjects. Diabetic patients divided into two groups. All subjects were matched according to age and sex. The mean waist circumference, systolic and diastolic blood pressure, triglyceride and fasting blood glucose levels and body mass index were significantly higher in the subjects with metabolic syndrome than control group, but the mean HDL-cholesterol was significantly lower (p = 0.0001). Mean serum level of FGF21 was higher in type 2 diabetic subjects with and without metabolic syndrome than that of control subject (p = 0.0001). There were significant negative correlation between FGF21 and BMI, diastolic blood pressure and HDL-cholesterol in subjects with metabolic syndrome (p<0.05). There were also significant negative correlation between FGF21 and cholesterol and HDL-cholesterol in control group (p<0.05). The findings of this study suggest that serum FGF21 are higher in patients with type 2 diabetes with and without metabolic syndrome than in age and sex matched control group. Our study shows that some of metabolic syndrome components (especially HDL-cholesterol) are associated with high serum FGF21 levels. Because of different effects of FGF21 in rodents, primates and in humans, it may require more investigating on metabolic effects of FGF21 in human's samples.

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Section: Discussioncontrasting

confidence: 95%

Section: Discussionmentioning

confidence: 89%

Serum Level of Fibroblast Growth Factor 21 in Type 2 Diabetic Patients with and without Metabolic Syndrome

Shafaei¹,

Khoshnia²,

Marjani³

2015

J. of Medical Sciences

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“…In previous studies, increased levels of FGF 21 have been reported to be associated with some diseases in which insulin resistance plays a major role, such as obesity [7], T2DM [8], impaired glucose tolerance (IGT) [9], gestational diabetes mellitus [10], non-alcoholic steatohepatitis (NASH) [11], and metabolic syndrome (MS) [7].…”

Section: Introductionmentioning

confidence: 99%

Fıbroblast growth factor 21 and ıts relatıonshıp wıth ınsulın sensıtıvıty ın fırst-degree relatıves of patıents wıth type 2 dıabetes mellıtus

Ors

Altınova

Yalcin

et al. 2015

Endokrynologia Polska

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“…In this study we were also interested in assessing the association of FGF21 with GDM, since FGF21 was previously found to significantly correlate with markers of insulin resistance and dyslipidemia [32] and to play a role in the pathogenesis of T2DM [33]. Our data indicated significantly higher unadjusted serum FGF21 levels in GDM women compared to the healthy pregnant controls.…”

Section: Enzyme-linked Immunosorbent Assay (Elisa)mentioning

confidence: 68%

Insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1, and fibroblast growth factor (FGF) 21 serum levels in Chinese women with and without gestational diabetes

Seto-Young¹,

Avtanski²,

Kim³

et al. 2017

Clin Obstet Gynecol Reprod Med

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Background: Although Asians are generally characterized by lower body mass index (BMI) compared to Caucasians, the prevalence of gestational diabetes mellitus (GDM) among Asian women is higher. Our previous studies found that, like the Caucasians, pregnant Chinese women show difference between GDM and non-GDM in the levels of total adiponectin. However, there is no difference in other inflammatory markers such as CRP, TNFα, IL-6 or MCP-1. The aim of the present study was to assess the IGF-I, IGFBP-1, and FGF21 levels in Chinese-American women with and without GDM.

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Serum fibroblast growth factor 21 levels in gestational diabetes mellitus in relation to insulin resistance and dyslipidemia

Cited by 75 publications

References 27 publications

Serum Level of Fibroblast Growth Factor 21 in Type 2 Diabetic Patients with and without Metabolic Syndrome

Serum Level of Fibroblast Growth Factor 21 in Type 2 Diabetic Patients with and without Metabolic Syndrome

Fıbroblast growth factor 21 and ıts relatıonshıp wıth ınsulın sensıtıvıty ın fırst-degree relatıves of patıents wıth type 2 dıabetes mellıtus

Insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1, and fibroblast growth factor (FGF) 21 serum levels in Chinese women with and without gestational diabetes

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