Serum fibroblast growth factor 21 level is increased in pre‐eclampsia patients: Association with blood pressure and lipid profile

Abstract

BackgroundPre‐eclampsia (PE) is dangerous complication, which leads to adverse pregnancy outcomes.AimsThe study was to explore the correlation between serum level of fibroblast growth factor (FGF) 21 and PE.MethodsA total of 80 cases were involved in this study containing PE group (49 cases) and control group (31 cases, normal pregnancy). PE group was divided into early‐onset PE (EOPE) and late‐onset PE (LOPE). Serum level of FGF21 and biochemical parameters were measured before delivery.ResultsMaternal serum FGF21 level was higher in PE especially in EOPE than that in control groups (P < 0.05). In PE patients, serum FGF21 level was positively correlated with mean arterial pressure, diastolic blood pressure and low‐density lipoprotein cholesterol (P < 0.05). Levels of FGF21, uric acid and low‐density lipoprotein cholesterol were risk factors for PE.ConclusionMaternal serum FGF21 level in PE particularly in EOPE was higher and was associated with blood pressure and lipid profile.

Maternal Fibroblast Growth Factor 21 Levels Decrease during Early Pregnancy in Normotensive Pregnant Women but Are Higher in Preeclamptic Women—A Longitudinal Study

“…Finally, our results show that serum FGF-21 levels are significantly higher in preeclamptic pregnant women compared to healthy normotensive pregnant women in the three trimesters of pregnancy in a longitudinal cohort, and these findings are broadly consistent with other cross-sectional studies [ 18 , 20 ]. Moreover, the AUC ROC for predicting adverse maternal outcome of mild preeclampsia from serum FGF-21 levels was determined in the first (0.681 (95% confidence interval 0.537–0.826)) which was slightly better for prediction than during the second (0.644 (95% confidence interval 0.501–0.788)) and third (0.680 (95% confidence interval 0.523–0.836)) trimesters of pregnancy.…”

“…Furthermore, NEFA and triglycerides were increased in preeclamptic patients compared with the control group [ 59 ]. In accordance with the results obtained by Lin Jiang et al, the current study presents for the first time the longitudinal profile of FGF-21 in healthy and preeclamptic women, where FGF-21 levels are significantly elevated at each trimester of pregnancy in preeclamptic women compared with normotensive women, results that could correlate FGF-21, hypertension and NEFA during pregnancy [ 20 ].…”

“…Recently, Xuebo et al, demonstrated in knockout FGF-21 mice significant angiotensin II-induced high blood pressure and vascular dysfunction, whereas replenishment with FGF-21 reversed the hypertension impairment [ 58 ]. Recent cross-sectional studies showed that maternal serum levels of FGF-21 were higher in preeclamptic pregnant women when compared with normotensive control groups [ 18 , 20 ]. Furthermore, NEFA and triglycerides were increased in preeclamptic patients compared with the control group [ 59 ].…”

“…As preeclampsia may be associated with endothelial dysfunction, it is not surprising that it can lead to a number of short and long-term health complications, including chronic hypertension, cardiovascular complications and renal complications [ 17 ]. Previous cross-sectional studies have demonstrated significant changes in maternal FGF-21 concentrations in preeclamptic women compared to healthy normotensive pregnant women [ 18 , 19 , 20 ]. Although the precise mechanisms responsible for driving preeclampsia remain to be elucidated, the role of FGF-21 in the pathophysiology of preeclampsia should be considered.…”

Biomarkers of environmental enteric dysfunction and adverse birth outcomes: An observational study among pregnant women living with HIV in Tanzania

“… 49 However, a recent case-control study conducted in China found higher serum FGF21 near the time of birth was associated with increased risk of preeclampsia and early-onset preeclampsia in particular, and higher levels of FGF21 were also associated with elevated mean arterial pressure, diastolic blood pressure, and low-density lipoprotein cholesterol. 50 …”