Serum Fibrin Degradation Products Throughout Normal Pregnancy

Woodfield, D. G.; Cole, Susan; Allan, A. G. E.; Cash, J. D.

doi:10.1136/bmj.4.5632.665

Cited by 57 publications

(23 citation statements)

References 32 publications

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“…3), in whom the first symptoms developed several days after Caesarean section performed after the term of a normal pregnancy, had received no oxytocic drugs. It is known that the high incidence of placental lesions encountered in late normal pregnancy encourages the release of thromboplastin and hence intravascular coagu lation [27]; Caesarean section may, therefore, aggravate and prolong this coagulatory disturbance [2], It is thus possible that in our patient the late pregnancy and the Caesarean section may have provoked intravascular coagulation; its presence is indicated by the thrombocytopenia, the marked increase in fibrin degradation products in the serum, and the thrombosis of the renal arterioles, and by the deposits of fibrinogen in the small vessels and glomeruli revealed on immunofluorescence. In this case the intra vascular coagulation probably developed less suddenly than is usual in eclampsia, so that the symptoms would appear only several days after expulsion of the placenta [17].…”

Section: Discussionmentioning

confidence: 99%

Post-Partum Renal Failure with Microangiopathic Haemolytic Anaemia

Ponticelli¹,

Imbasciati²,

Tarantino³

et al. 1972

Nephron

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Five cases of acute post-partum renal failure with microangiopathic haemolytic anaemia are reported. In 4 patients the pregnancy had been complicated by preeclampsia or frank eclampsia, and in 1 patient the symptoms appeared some days after caesarean section performed beyond the term of a normal pregnancy. The presence of intravascular coagulation was indicated by thrombocytopenia, increase in fibrin degradation products in the serum, and by the finding on renal biopsy of intra-arteriolar and intraglomerular thrombosis. All the patients were given anticoagulant therapy (heparin alone or with dipyridamole). One patient died after 40 days with no improvement in the haematological or renal symptoms. The remaining 4 cases showed an improvement in renal function, and the haemolytic anaemia resolved. Control renal biopsy performed in 3 cases after varying intervals showed fibrous thickening of the intima of the arterioles and interlobular arteries. Anticoagulant therapy was continued over a prolonged period with the object of preventing further deposition of fibrin and platelet aggregation on the arteriolar lesions. The surviving patients have remained in good health for 38, 27, 20 and 6 months, respectively, after the delivery. These results should confirm the utility of anticoagulant therapy in microangiopathic haemolytic anaemia with renal failure, occurring during or after pregnancy.

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Section: Discussionmentioning

confidence: 99%

Post-Partum Renal Failure with Microangiopathic Haemolytic Anaemia

Ponticelli¹,

Imbasciati²,

Tarantino³

et al. 1972

Nephron

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“…levels are slightly raised in late normal pregnancy (Woodfield, Cole, Allan, and Cash, 1968) and postpartum (Bonnar et al, 1969a). F.D.P.…”

Section: Discussionmentioning

confidence: 88%

“…A similar but milder process, where fibrin deposition is limited to the renal microcirculation, may occur in toxaemia (McKay et al, 1953;McKay and Corey, 1964). The possibility that much of the implied increase in fibrin formation takes place in the uterine and placental vessels (Woodfield et al, 1968) cannot be excluded. It has been postulated that disseminated intravascular coagulation could be triggered by the release of thromboplastin from the placenta (McKay and Corey, 1964).…”

Section: Discussionmentioning

confidence: 99%

Fibrin Degradation Products in Pre-eclamptic Toxaemia and Eclampsia

Henderson¹,

Pugsley²,

Thomas³

1970

BMJ

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“…This syndrome has been associated with many disparate conditions, such as pregnancy toxaemia, septicaemia, amniotic fluid embolism, hypertension, snake bite and shock (e.g., the reviews by Pitney, 1971 and Simpson and Stalker, 1973 Pregnancy is associated with changes in the fibrinogen/plasminogen system, although the details are still subject to dispute probably related to technical differences (Woodfield et al, 1968;Bonnar et al, 1969). A variety of changes in coagulation factors and their inhibitors have been observed in patients receiving oestrogen-progestogen preparations (e.g., Brackman and Astrup, 1964;Ygge et al, 1969;Howie et al, 1970).…”

Section: Discussionmentioning

confidence: 99%

Pancreatitis, multiple infarcts and oral contraception

Foster

Powell

1975

Postgraduate Medical Journal

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Summary The fact that oral contraceptives may predispose to thrombosis is not disputed, although its frequency is still debated. Any reliable assessment of the prevalence of this complication must in the main depend on careful statistical studies of well controlled groups, because the isolated case may well be coincidental when conditions such as coronary thrombosis, cerebral thrombosis, and pulmonary embolism are not extreme rarities in adult women. However, occasionally the clinical and pathological findings are so striking that they afford compelling evidence. The patient to be described presented with clinical features of pancreatitis that did not initially suggest an association with oral contraception. A hitherto undescribed state of multiple infarcts was found at post-mortem. This also illustrates the way in which the official figures for thrombotic complications can be underestimated.

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Serum Fibrin Degradation Products Throughout Normal Pregnancy

Cited by 57 publications

References 32 publications

Post-Partum Renal Failure with Microangiopathic Haemolytic Anaemia

Post-Partum Renal Failure with Microangiopathic Haemolytic Anaemia

Fibrin Degradation Products in Pre-eclamptic Toxaemia and Eclampsia

Pancreatitis, multiple infarcts and oral contraception

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