Serum Fetuin-A Associates with Type 2 Diabetes and Insulin Resistance in Chinese Adults

Abstract

BackgroundPrevious studies have demonstrated that fetuin-A is related to insulin resistance among subjects with normal glucose tolerance but not patients with type 2 diabetes. There are limited data available concerning fetuin-A and insulin resistance in Chinese. We aimed to study the association of feuin-A with insulin resistance among participants with or without type 2 diabetes in a large sample size of adults aged 40 and older.Methodology and Principal FindingsA community-based cross-sectional study was performed among 5,227 Chinese adults. The average age of our study was 61.5±9.9 years. Serum fetuin-A concentrations were not significantly different between male and female (296.9 vs. 292.9 mg/l, p = 0.11). Compared with the lowest quartile, the highest quartile of serum fetuin-A revealed a significant higher proportion of type 2 diabetic patients (34.8% vs. 27.3%, p<0.0001). In the multinomial logit models, the risk of type 2 diabetes was associated with each one quartile increase of serum fetuin-A concentrations when referenced not only to normal glucose tolerance (OR 1.24, 95% CI 1.07–1.43, p = 0.004) but also to impaired glucose regulation (OR 1.25, 95% CI 1.08–1.44, p = 0.003, respectively), after adjustment for age, sex, community, current smoking, and current drinking. The logistic regression analysis showed that fetuin-A were associated with elevated HOMA-IR and fasting serum insulin both among the participants with or without type 2 diabetes in the full adjusted analysis. There was no significant association between elevated serum fetuin-A concentrations and impaired glucose regulation (all p≥0.12).Conclusions and SignificanceHigher fetuin-A concentrations were associated with type 2 diabetes and insulin resistance in middle aged and elderly Chinese.

Association of Insulin Resistance, β-Cell Function Impairment and Calcium, Magnesium, and Fetuin-A Concentrations in Women with Type 2 Diabetes Mellitus

“…Our results are consistent with those described in previous studies (20,21). Moreover, serum fetuin-A is related to prediabetes, diabetes type 2, and IR in Chinese population aged ≥40 years (22). …”

“…Our study demonstrated that serum fetuin-A was related to IR, and HOMA2IR index and fasting insulin serum levels were increased; this result is consistent with previous results (4,(22)(23)(24). Therefore, fetuin-A may be used as a new factor implicated in T2DM pathology and physiology; IR also plays an important role in the T2DM mechanism (25).…”

“…The risk factors of diabetes are age, gender, BMI, waist measurement, and other contributing factors. Fetuin-A is also correlated with pre-diabetes, T2DM, and IR in a Chinese population aged ≥40 years old (22). Fetuin-A is also related to T2DM in an American population aged ˃70 years (30) and in a German population aged 35-65 years (6).…”

“…Other parameters were also significantly and positively correlated with serum fetuin-A; therefore, increased fetuin-A level is associated with IR. However, the increased serum fetuin-A level is not significantly correlated with the loss of glucose regulation (22).…”

The Effect of Different Ovarian Stimulation Protocols on Multifunctional Fetuin_a Concentration in the Serum and Follicular Fluid of Women With Pcos Undergoing Icsi/Ivf.

“…It is more abundant in fetal than adult circulation (4) and synthesized in the liver secreted into serum processed from a single chain precursor to the mature circulating twochain form by proteolytic processing in the Golgi apparatus to form a light and a heavy chain consisting of 27 and 321 amino acids, respectively. The mature form of fetuin-A has three domains so this complex structure of fetuin-A suggests multiple biological functions.…”