Serum Ferritin, Vitamin D and Pathological Factors in Breast Cancer Patients

Fadavi, Pedram; Nafisi, Nahid; Hariri, Ramyar; Novin, Kambiz; Sanei, Mastaneh; Razzaghi, Zahra; Arefpour, A; Garousi, Maryam

doi:10.47176/mjiri.35.162

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…However, the excess of iron ultimately promotes cancer cell progression by inducing immune suppression through T (and B) lymphocytes anergy and apoptosis [10], and by impairing antigen-presenting cells (APCs) activity [11]. Moreover, increased iron availability could enhance the rate of cell replication; in fact, it has recently been demonstrated that high ferritin levels are associated with a worse prognosis in breast cancer [12,13].…”

Section: Discussionmentioning

confidence: 99%

Ferritin Metabolism Reflects Multiple Myeloma Microenvironment and Predicts Patient Outcome

Plano,

Gigliotta,

Corsale

et al. 2023

IJMS

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Multiple myeloma (MM) is a hematologic malignancy with a multistep evolutionary pattern, in which the pro-inflammatory and immunosuppressive microenvironment and genomic instability drive tumor evolution. MM microenvironment is rich in iron, released by pro-inflammatory cells from ferritin macromolecules, which contributes to ROS production and cellular damage. In this study, we showed that ferritin increases from indolent to active gammopathies and that patients with low serum ferritin had longer first line PFS (42.6 vs. 20.7 months and, p = 0.047, respectively) and OS (NR vs. 75.1 months and p = 0.029, respectively). Moreover, ferritin levels correlated with systemic inflammation markers and with the presence of a specific bone marrow cell microenvironment (including increased MM cell infiltration). Finally, we verified by bioinformatic approaches in large transcriptomic and single cell datasets that a gene expression signature associated with ferritin biosynthesis correlated with worse outcome, MM cell proliferation, and specific immune cell profiles. Overall, we provide evidence of the role of ferritin as a predictive/prognostic factor in MM, setting the stage for future translational studies investigating ferritin and iron chelation as new targets for improving MM patient outcome.

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Section: Discussionmentioning

confidence: 99%

Ferritin Metabolism Reflects Multiple Myeloma Microenvironment and Predicts Patient Outcome

Plano,

Gigliotta,

Corsale

et al. 2023

IJMS

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“…For example, breast cancer patients have significantly higher levels of iron than normal controls. 67,68 Thus, cancers with high levels of iron might be more susceptible to AA through increased production of free radicals via LIP. In a research reported by Xia et al, high dose AA, in the presence of iron, leads to the formation of highly ROS resulting in cell death of multiple myeloma cells.…”

Section: Pro-oxidantmentioning

confidence: 99%

Ascorbic acid in cancer management – time for a second look

Ogochukwu

2023

Eur J Clin Exp Med

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Introduction and aim. Over the past decades, the hypotheses that ascorbic acid (AA) can play a role as an anti-neoplastic therapy have generated many conflicting reports. Despite the controversies, mounting evidence has shown that AA has the potential to play a role as an anti-neoplastic agent. Recent studies have unraveled its pharmacokinetics and various mechanism of action on cancer cells. This has spawned different preclinical studies with reports of good activities against various cancers. Material and methods. A review of the literature regarding ascorbic acid in the management of cancer was performed using the PubMed database. The research was limited to abstracts and available full-text articles. Analysis of the literature. Clinical trials have also demonstrated its safety and tolerability across different dosages. AA has been noted as a multitargeting agent that acts as a pro-oxidative cytotoxic agent, anti-cancer epigenetic regulator and immune modulator. AA has also been shown act synergistically with standard chemotherapy regimens in different cancers. Despite its potentials, phase III clinical trials are seriously lacking. The recent phase III VITALITY study shows that AA may play a role as an adjunct targeted therapy for ras-mutated cancers. Therefore, there is need to for more standardized clinical trials to help identify cancer subtypes and AA combination regimens that can show the most benefits. In this review, the pleiotropic mechanism of action of AA was explored as well as various preclinical and clinical studies in cancer therapy. In addition, recommendations were also made for effective strategies towards an AA and standard cancer regimens in treatment as well as future directions. Ascorbic acid has been shown to induce cell death in various cancer types through different mechanisms of action. Several clinical trials and case reports have shown its efficacy in combination chemotherapy, and the pharmacological route of action can be either intravenous or oral. However, it can impair the actions of some drugs when given in combination. Also, dosage should be determined for maximal pharmacologic action. Conclusion. Ascorbic acid has the potential to provide safe and cost-effective antineoplastic treatment option especially in combination therapy. Its potential needs to be further investigated through clinical trials.

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“…Lately, several studies have correlated the increased amounts of this protein with the higher risk of developing oncologic disorders, as well as prognosing the positive or negative advance of the disease. Regarding breast cancer, increased sFT has been positively associated with the increased incidence of the disease [89], and even with the severity of cancer progression [90]. Increased levels of FT are also a good indication of an escalated risk of pancreatic cancer development [91].…”

Section: Role Of Circulating Ferritin In Health and Diseasementioning

confidence: 99%

New Perspectives on Circulating Ferritin: Its Role in Health and Disease

Fonseca,

Ramos,

Gomes

et al. 2023

Molecules

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The diagnosis of iron disturbances usually includes the evaluation of serum parameters. Serum iron is assumed to be entirely bound to transferrin, and transferrin saturation—the ratio between the serum iron concentration and serum transferrin—usually reflects iron availability. Additionally, serum ferritin is commonly used as a surrogate of tissue iron levels. Low serum ferritin values are interpreted as a sign of iron deficiency, and high values are the main indicator of pathological iron overload. However, in situations of inflammation, serum ferritin levels may be very high, independently of tissue iron levels. This presents a particularly puzzling challenge for the clinician evaluating the overall iron status of the patient in the presence of an inflammatory condition. The increase in serum ferritin during inflammation is one of the enigmas regarding iron metabolism. Neither the origin, the mechanism of release, nor the effects of serum ferritin are known. The use of serum ferritin as a biomarker of disease has been rising, and it has become increasingly diverse, but whether or not it contributes to controlling the disease or host pathology, and how it would do it, are important, open questions. These will be discussed here, where we spotlight circulating ferritin and revise the recent clinical and preclinical data regarding its role in health and disease.

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Serum Ferritin, Vitamin D and Pathological Factors in Breast Cancer Patients

Abstract: Background safer methods. comprehensive stages. Methods: Th any treatment a information of Data were ana significant. Results: Eigh cancer patients (p=0.083). Fur (p=0.001). 3 (1 vitamin D high Conclusion: Perhaps with fu

Cited by 4 publications

References 16 publications

Ferritin Metabolism Reflects Multiple Myeloma Microenvironment and Predicts Patient Outcome

Ferritin Metabolism Reflects Multiple Myeloma Microenvironment and Predicts Patient Outcome

Ascorbic acid in cancer management – time for a second look

New Perspectives on Circulating Ferritin: Its Role in Health and Disease

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