Serum ferritin, sex hormones, and cardiovascular risk factors in healthy women.

Berge, Lillian Nordbø; Bønaa, Kaare Harald; Nordøy, Arne

doi:10.1161/01.atv.14.6.857

Cited by 62 publications

(37 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In effect, a link was found in the present study between serum ferritin and serum cholesterol, in agreement with Berge et al's study [48] on postmenopausal women of similar age. Ramakrishnan et al [49] demonstrated that serum cholesterol concentrations were higher among subjects with the highest serum ferritin values.…”

Section: Discussionsupporting

confidence: 94%

Is Serum Ferritin an Additional Cardiovascular Risk Factor for All Postmenopausal Women?

Massé

Dosy

Cole³

et al. 2004

Ann Nutr Metab

View full text Add to dashboard Cite

Background: Most of the studies on cardiovascular disease (CVD) risk factors in menopause have focused on serum lipid(lipoprotein) abnormalities and were conducted in populations which were not well controlled for several important influential factors. Methods: Two homogenous groups of 30 apparently healthy Caucasian premenopausal women and 3–5 years postmenopausal women who were nonobese, nonsmoking and not using estrogen were compared in a well-controlled cross-sectional design. Fasting serum ferritin and plasma total homocysteine (tHcy) were evaluated concomitantly to classical serum lipid(lipoprotein) risk factors. Relationships between risk factors and the influence of other contributing variables such as diet and body weight were also examined. Results: Serum total cholesterol (p < 0.01), low-density lipoproteins (LDL; p < 0.05) and triglycerides (p < 0.05) of postmenopausal women were greater than that of their menstruating counterparts, even though they ate a CVD-preventive diet, had similar body weight and body fat distribution. Their serum ferritin was almost 3-fold greater (p < 0.0001) but was still within normal limits, except for the 38.5% of postmenopausal women who exhibited values above the 80 µg/l limit that has been associated with sharp increases in the rate of heart disease in either gender. Serum ferritin was low in one third of the postmenopausal group (as low as in the premenopausal control group, whose dietary iron intake was slightly below the nutritional recommendation). The mean plasma tHcy of the postmenopausal group was almost twice as elevated (p < 0.0001). Both ferritin and tHcy were found to be linked to serum cholesterol. The correlation between tHcy and triglycerides was also significant. Conclusion: Early menopause is not associated with blood iron overload and CVD risk factor in an important proportion of women.

show abstract

Section: Discussionsupporting

confidence: 94%

Is Serum Ferritin an Additional Cardiovascular Risk Factor for All Postmenopausal Women?

Massé

Dosy

Cole³

et al. 2004

Ann Nutr Metab

View full text Add to dashboard Cite

show abstract

“…Iron absorption is typically inversely related to iron stores, 52 and postmenopausal women generally have higher iron stores than premenopausal or perimenopausal women. 53 For example, the average serum ferritin concentration in the postmenopausal women was 65.4 ng/mL, 18 compared to 27.3 ng/ mL in our premenopausal women. Our current results from premenopausal women agree with those from the perimenopausal women, 17 but not from those of the postmenopausal 18 women, strongly supporting the hypothesis that subjects with low iron status have higher absorption than those with adequate iron status, particularly from foods with low iron bioavailability.…”

mentioning

confidence: 48%

The Effect of Soy Food Intake on Mineral Status in Premenopausal Women

Zhou¹,

Alekel²,

Dixon

et al. 2011

Journal of Women's Health

View full text Add to dashboard Cite

Background: Soy foods have been substituted for meat in recent years because of proposed health benefits. Research indicates, however, that soy protein and phytate in soy products inhibit the absorption of divalent cations. Methods: Our study was primarily designed to determine the effect of consuming two to three servings per day of soy foods, providing *19 g protein and *36 mg isoflavones, on iron and zinc status in premenopausal women during a 10-weeks period. As secondary outcomes, we also tested the effect of soy foods on biochemical markers of bone and thyroid hormones. Nonsmoking women (18-28 years) without chronic disease, anemia, pregnancy, or irregular menstrual cycles were randomly assigned to either the soy food (SF, n = 31) or animal food (AF, n = 32) group. Blood and urine samples and 3-day dietary records were collected at baseline and postintervention. Results: At baseline, iron and zinc status, bone markers, and thyroid hormones were not different between groups. After intervention, no significant changes were observed in hemoglobin, transferrin saturation, serum iron, ferritin, or transferrin receptor (TFR) concentrations. Plasma zinc, but not serum alkaline phosphatase, significantly decreased in both groups ( -0.8 lmol/L).

show abstract

“…These abnormalities might lead to increased adiposity. Several studies have demonstrated correlations between serum ferritin concentrations and other components of the insulin resistance syndrome (3,4,16). It has been reported that the chelation of iron is highly resistant to oxidant-mediated injury (13) and is associated with reduced iron-induced lipid peroxidation (17).…”

Section: Multiple Regression Analysismentioning

confidence: 99%

Serum Ferritin Is Associated With Visceral Fat Area and Subcutaneous Fat Area

et al. 2005

View full text Add to dashboard Cite

OBJECTIVE -Until now, few clinical studies have reported on the association between the indexes of body fat distribution and serum ferritin, an indicator of body iron stores and a putative risk factor for insulin resistance. We investigated the association between serum ferritin concentrations and the indexes of distribution of adipose tissues in the body, such as the visceral fat area (VFA), the subcutaneous fat area (SFA), and the hepatic fat content in Japanese subjects.RESEARCH DESIGN AND METHODS -A total of 248 Japanese subjects (127 men and 121 postmenopausal women aged 57.8 Ϯ 13.9 years, BMI 25.7 Ϯ 4.6 kg/m 2 ; 140 subjects with type 2 diabetes and 108 nondiabetic subjects) were evaluated. Subjects with a history of alcohol intake were excluded from the study. We measured body height, body weight, and serum ferritin, as well as fasting plasma glucose and plasma insulin concentrations. We estimated insulin resistance by homeostasis model assessment. The fat distribution was evaluated by measuring the VFA and SFA by abdominal computed tomography at the umbilical level. To assess the hepatic fat content, the ratio of the computed tomography attenuation value of the liver to that of the spleen was calculated.RESULTS -Serum ferritin was significantly correlated with the various indexes of adiposity examined, such as the hepatic fat content (r ϭ Ϫ0.280, P Ͻ 0.0001), VFA (r ϭ 0.254, P Ͻ 0.0001), SFA (r ϭ 0.231, P ϭ 0.0005), and homeostasis model assessment (r ϭ 0.286, P ϭ 0.0008).CONCLUSIONS -This is the first report to directly demonstrate an association between serum ferritin and VFA and SFA. The results of this study suggest that the serum ferritin concentration may be a useful indicator of systemic fat content and degree of insulin resistance. Diabetes Care 28:2486 -2491, 2005P revious studies (1,2) have investigated the relationship between radiologically measured abdominal fat accumulation, hepatic fat content, and metabolic risk factors. It has been reported that both the visceral fat area (VFA) and the hepatic fat content are correlated with plasma triglyceride levels and glucose disposal (1,2). Elevation of serum ferritin concentrations has been suggested to be one of the components of the insulin resistance syndrome (3)(4)(5). In a population study of 1,013 eastern Finnish men (3), the serum ferritin concentrations were shown to be well correlated with the fasting plasma glucose and insulin concentrations. A subsequent study also revealed that circulating ferritin levels were related to the degree of insulin resistance (4). However, only a few studies have reported on the relationship between the serum ferritin concentrations and various indexes of adiposity. A study of Spanish subjects demonstrated no association between serum ferritin concentrations and the waist-to-hip ratio (4). On the other hand, a study of Norwegian men demonstrated independent associations between serum ferritin concentrations and the waist-to-thigh ratio and BMI (6). Gillum et al. also reported that the serum ferritin concentra...

show abstract

Serum ferritin, sex hormones, and cardiovascular risk factors in healthy women.

Cited by 62 publications

References 28 publications

Is Serum Ferritin an Additional Cardiovascular Risk Factor for All Postmenopausal Women?

Is Serum Ferritin an Additional Cardiovascular Risk Factor for All Postmenopausal Women?

The Effect of Soy Food Intake on Mineral Status in Premenopausal Women

Serum Ferritin Is Associated With Visceral Fat Area and Subcutaneous Fat Area

Contact Info

Product

Resources

About