Serum ferritin level is associated with liver steatosis and fibrosis in Korean general population

Jung, Ju Young; Shim, Jae‐Jun; Park, Sung Keun; Ryoo, Jae‐Hong; Choi, Joong-Myung; Oh, In‐Hwan; Jung, Kyu-Won; Cho, Hyunsoon; Ki, Moran; Won, Young‐Joo; Oh, Chang‐Mo

doi:10.1007/s12072-018-9892-8

Cited by 48 publications

(55 citation statements)

References 33 publications

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“…Our results corroborate that meat consumption, specifically red meat, was associated with ferritin concentration which could be influencing the development of NAFLD. Other research studies observed a relationship between ferritin and elevated ALT, a surrogate of liver damage [30,32,33]. In this context, we observed that participants above the median of red meat consumption presented higher ferritin and ALT concentrations than those with lower red meat consumption.…”

Section: Discussionsupporting

confidence: 66%

“…Excess circulating iron is potentially toxic, leading to the formation of reactive oxygen species, which can contribute to oxidative stress in NASH [28,29]. Increased serum ferritin level is closely related with insulin resistance and impaired glucose tolerance and NAFLD pathogenesis [30]. According to Willman et al, 2019, after a 6-month dietary intervention, a significant decrease on ferritin levels was found in participants corresponding to the “no red meat group” [31].…”

Section: Discussionmentioning

confidence: 99%

“…Due to the high bioavailability, heme-iron absorption rates are four to five times higher than non-heme iron, considered as the main contributor to stored body iron [42]. The detrimental effects of liver iron and ferritin on health have been described by several authors [29,30,42].…”

Section: Discussionmentioning

confidence: 99%

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Association between Different Animal Protein Sources and Liver Status in Obese Subjects with Non-Alcoholic Fatty Liver Disease: Fatty Liver in Obesity (FLiO) Study

Recaredo

Cantero

et al. 2019

Nutrients

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Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome. Obesity and unhealthy dietary habits are described as risk factors for NAFLD. The aim of this study was to investigate the association between the consumption of different animal protein sources and hepatic status in NAFLD adults. A total of 112 overweight/obese participants with NAFLD from Fatty Liver in Obesity (FLiO) study were evaluated at baseline. Diet, body composition, and biochemical variables were evaluated. Hepatic status was also assessed by Magnetic Resonance Imaging, ultrasonography, and elastography. Red meat consumption showed a positive relationship with liver iron content (r = 0.224; p = 0.021) and ferritin concentration (r = 0.196; p = 0.037). Processed meat consumption exhibited a positive association with liver iron content (r = 0.308; p = 0.001), which was also found in the quantile regression (β = 0.079; p = 0.028). Fish consumption was related with lower concentration of ferritin (r = −0.200; p = 0.034). This association was further evidenced in the regression model (β = −0.720; p = 0.033). These findings suggest that the consumption of different animal protein sources differentially impact on liver status in obese subjects with NAFLD, showing fish consumption as a healthier alternative for towards NAFLD features.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

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Association between Different Animal Protein Sources and Liver Status in Obese Subjects with Non-Alcoholic Fatty Liver Disease: Fatty Liver in Obesity (FLiO) Study

Recaredo

Cantero

et al. 2019

Nutrients

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show abstract

“…The liver is the major site of systemic iron regulation [34]. Hepatocytes constitute the major parenchymal iron storage pool and contain large amounts of ferritin, the primary iron storage protein [35]. Iron is an essential but potentially toxic element that may promote the onset and progression of NAFLD by increasing oxidative stress and altering insulin signaling and lipid metabolism [14,15,36,37].…”

Section: Discussionmentioning

confidence: 99%

Predictive Value of Serum Ferritin in Combination with Alanine Aminotransferase and Glucose Levels for Noninvasive Assessment of NAFLD: Fatty Liver in Obesity (FLiO) Study

et al. 2020

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The identification of affordable noninvasive biomarkers for the diagnosis and characterization of nonalcoholic fatty liver disease (NAFLD) is a major challenge for the research community. This study aimed to explore the usefulness of ferritin as a proxy biomarker of NAFLD condition, alone or in combination with other routine biochemical parameters. Subjects with overweight/obesity and ultrasound-confirmed liver steatosis (n = 112) from the Fatty Liver in Obesity (FLiO) study were assessed. The hepatic evaluation considered magnetic resonance imaging, ultrasonography, and credited routine blood liver biomarkers. Anthropometry and body composition, dietary intake (by means of a validated 137-item food frequency questionnaire), and specific biochemical markers were also determined. Serum ferritin levels were analyzed using a chemiluminescent microparticle immunoassay kit. Lower serum ferritin concentrations were associated with general better liver health and nutritional status. The evaluation of ferritin as a surrogate of liver damage by means of quantile regression analyses showed a positive association with alanine aminotransferase (ALT) (β = 19.21; p ≤ 0.001), liver fat content (β = 8.70; p = 0.008), and hepatic iron (β = 3.76; p ≤ 0.001), after adjusting for potential confounders. In receiver operating characteristic (ROC) analyses, the panel combination of blood ferritin, glucose, and ALT showed the best prediction for liver fat mass (area under the curve (AUC) 0.82). A combination of ferritin and ALT showed the higher predictive ability for estimating liver iron content (AUC 0.73). This investigation demonstrated the association of serum ferritin with liver health as well as with glucose and lipid metabolism markers in subjects with NAFLD. Current findings led to the identification of ferritin as a potential noninvasive predictive biomarker of NAFLD, whose surrogate value increased when combined with other routine biochemical measurements (glucose/ALT).

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“…In this issue of Hepatology International, Jung et al [21] examine the utility of serum ferritin to identify NAFLD using data from 25,597 participants in the Korean National Health and Nutritional Examination Survey (KNHANES). The population was divided by sex and then divided further into quartiles by ferritin levels.…”

mentioning

confidence: 99%

Serum ferritin as a biomarker for NAFLD: ready for prime time?

Shah

Kowdley

2019

Hepatol Int

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Serum ferritin level is associated with liver steatosis and fibrosis in Korean general population

Abstract: Elevation of serum ferritin level is significantly associated with NAFLD and blood ALT elevation in Korean general population.

Cited by 48 publications

References 33 publications

Association between Different Animal Protein Sources and Liver Status in Obese Subjects with Non-Alcoholic Fatty Liver Disease: Fatty Liver in Obesity (FLiO) Study

Association between Different Animal Protein Sources and Liver Status in Obese Subjects with Non-Alcoholic Fatty Liver Disease: Fatty Liver in Obesity (FLiO) Study

Predictive Value of Serum Ferritin in Combination with Alanine Aminotransferase and Glucose Levels for Noninvasive Assessment of NAFLD: Fatty Liver in Obesity (FLiO) Study

Serum ferritin as a biomarker for NAFLD: ready for prime time?

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