Serum ferritin level is a prognostic marker in patients with peripheral T‐cell lymphoma

Koyama, Satoshi; Fujisawa, Shin; Watanabe, Reina; Itabashi, Megumi; Ishibashi, Daisuke; Ishii, Yoshimi; Hattori, Yukako; Nakajima, Yuki; Motohashi, Kenji; Takasaki, Hirotaka; Kawasaki, Rika; Hashimoto, Chizuko; Yamazaki, Etsuko; Koharazawa, Hideyuki; Takemura, Sachiya; Tomita, Naoto; Sakai, Rika; Motomura, Shigeki; Nakajima, Hitoshi

doi:10.1111/ijlh.12592

Cited by 27 publications

(22 citation statements)

References 17 publications

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“…[ 32 ] Recently, Koyama et al reported that serum CRP was associated with OS in univariate analysis in 78 patients consisting of 39 patients of AITL and 39 patients of PTCL, NOS. [ 33 ] According to our study, we propose that serum CRP plays an important role in AITL and conducts as an independent prognostic factor.…”

Section: Discussionmentioning

confidence: 79%

Clinical characteristics of angioimmunoblastic T-cell lymphoma in China and C-reactive protein as an independent prognostic factor

et al. 2017

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Section: Discussionmentioning

confidence: 79%

Clinical characteristics of angioimmunoblastic T-cell lymphoma in China and C-reactive protein as an independent prognostic factor

et al. 2017

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“…Some studies have reported that elevated serum ferritin was associated with malignancy . In addition, an association has been reported between serum ferritin and treatment response or prognosis . To our knowledge, however, no evidence to suggest a relationship between recent treatment for cancer and serum ferritin has yet been found.…”

Section: Discussionmentioning

confidence: 82%

“…21,22 In addition, an association has been reported between serum ferritin and treatment response or prognosis. [23][24][25] To our knowledge, however, no evidence to suggest a relationship between recent treatment for cancer and serum ferritin has yet been found. Of note, the ERI in the patients with recent cancer treatment was higher than in those without cancer in our study.…”

Section: Dialysis Treatment Indicators Of Single Pool Kt/v Treatmentmentioning

confidence: 99%

Dialysis‐related practice patterns among hemodialysis patients with cancer

Nishiwaki

Fukuma

Hasegawa

et al. 2018

Health Science Reports

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Rationale, aims, and objectivesWith the achievement of longevity in hemodialysis patients, the risk of comorbid cancer has begun to draw attention. In the present study, we examined dialysis‐related practice patterns and compared those patterns by cancer status.MethodsUsing data from the Japan Dialysis Outcomes and Practice Patterns Study phase 4, we evaluated 2153 hemodialysis patients. Baseline cancer status for patients was separated into 3 categories: no cancer, cancer with recent treatment, and cancer without recent treatment. We then assessed variations among hemodialysis patients in dialysis‐related practice patterns, including anemia management, management of mineral and bone metabolism disorder, nutritional management, and dialysis treatment, by cancer status.ResultsWe observed both similarities and differences in dialysis‐related practice patterns among hemodialysis patients, by cancer status. Hemoglobin levels were largely similar for all cancer statuses, although erythropoiesis stimulating agents dose tended to be higher in hemodialysis patients with recent cancer treatment (multivariable adjusted mean difference of erythropoiesis stimulating agents dose: 5.4 × 103 IU/L/month) than in those without cancer. Phosphorus and calcium levels were also similar. Nutrition statuses were similar among cancer statuses, as were dialysis therapies. These results suggested that physicians do not modulate their dialysis‐related practices based on whether or not a hemodialysis patient has cancer.ConclusionAmong long‐term facility‐based hemodialysis patients with cancer, we detected no statistically significant differences to suggest that cancer status affects hemodialysis practice regarding mineral and bone disorder management, nutritional management, and dialysis treatment. Facility‐based hemodialysis patients with recent cancer treatment, however, receive a higher dose of erythropoietin‐stimulating agent than those without cancer.

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“…The PFS of PTCL‐NOS was not associated with vitamin D deficiency, whereas the PFS of AITL showed a modest association, although it failed to show a statistical significance owing to relatively small numbers (data not shown). Considering that various single parameters related with immune function and inflammation, such as ferritin, have been reported to have prognostic value in PTCL, the role of vitamin D deficiency in the prognosis of PTCL needs to be further studied with a larger study population …”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency is associated with inferior survival of patients with extranodal natural killer/T‐cell lymphoma

et al. 2018

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Vitamin D deficiency is a common health issue; however, the effect of vitamin D deficiency on the survival of T‐cell lymphoma is still not clear. We evaluated the impact of serum vitamin D level of patients with peripheral T‐cell lymphoma (PTCL) and extranodal natural killer/T‐cell lymphoma (ENKTL) on survival outcome. Pretreatment levels of 25‐hydroxyvitamin D [25(OH)D] and inflammatory cytokines were measured in serum samples that were archived at diagnosis, and we evaluated their association with survival in newly diagnosed patients with PTCL (n = 137) and ENKTL (n = 114) at a university‐based hospital in Korea. An independent cohort from Rui Jin Hospital (Shanghai, China) was used for validation. The median 25(OH)D serum level was 12.0 ng/mL (1.3‐60.0 ng/mL), and 40% had less than 10 ng/mL, which was defined as vitamin D deficiency. Median serum 25(OH)D levels were similar between PTCL (11.5 ng/mL) and ENKTL (12.9 ng/mL); however, vitamin D deficiency was associated with inferior survival in ENKTL but not with PTCL. The independent validation cohort (n = 115) also showed a significant association of vitamin D deficiency with poor survival in ENKTL. The 25(OH)D level had an inverse relation with inflammatory cytokines; this association had a negative effect only on survival of ENKTL, and not on PTCL. In conclusion, vitamin D deficiency was associated with inferior survival outcome of patients with ENKTL.

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Serum ferritin level is a prognostic marker in patients with peripheral T‐cell lymphoma

Abstract: Serum ferritin level is a useful prognostic marker for PTCL.

Cited by 27 publications

References 17 publications

Clinical characteristics of angioimmunoblastic T-cell lymphoma in China and C-reactive protein as an independent prognostic factor

Clinical characteristics of angioimmunoblastic T-cell lymphoma in China and C-reactive protein as an independent prognostic factor

Dialysis‐related practice patterns among hemodialysis patients with cancer

Vitamin D deficiency is associated with inferior survival of patients with extranodal natural killer/T‐cell lymphoma

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