Serum ferritin level and red blood cell parameters in healthy controls and chronic periodontitis patients

Latha, S; Thirugnanamsambandan, S; Arun, RT; Masthan, K. M. K.; Malathi, L.; Rajesh, E.

doi:10.4103/0975-7406.155896

Cited by 8 publications

(4 citation statements)

References 16 publications

(16 reference statements)

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“…Moreover, it has been reported that Increased serum ferritin levels might be associated with the severity of CP [ 36 ]. While S. Latha et al found no difference in levels of serum ferritin between the CP group and the control group [ 37 ], which may be due to the differences in race, sample size, and inclusion standards. Moreover, in the present study, patients with CP and T2DM exhibited higher serum ferritin levels compared with the controls.…”

Section: Discussionmentioning

confidence: 99%

Serum and salivary ferritin and Hepcidin levels in patients with chronic periodontitis and type 2 diabetes mellitus

2018

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BackgroundIron disorder and abnormal expression of hepcidin play important roles in many diseases, but it is still unclear in chronic periodontitis (CP) and type 2 diabetes mellitus (T2DM). We aimed to assess ferritin and hepcidin levels in serum and saliva of CP patients with or without T2DM.MethodsSerum and unstimulated whole saliva samples were collected from 88 participants, who were categorized into 4 groups based on the presence or absence of CP or T2DM. Demographics and general health parameters were recorded. Full-mouth clinical periodontal parameters including probing pocket depth, clinical attachment loss, bleeding index, and plaque index were recorded. Chemiluminescence microparticle immunoassay and enzyme-linked immunosorbent assay were used to detect ferritin and hepcidin concentrations, respectively, in serum and saliva.ResultsSerum ferritin and hepcidin levels in the CP and CP with T2DM groups were higher than in the control group (P < 0.05). Serum hepcidin and serum ferritin are linear correlated (P < 0.001). Serum hepcidin/ferritin values in the CP with T2DM group were significantly lower than those in the T2DM and control groups. Moreover, salivary ferritin levels in the CP and T2DM groups were higher than those in the control group (P < 0.05). There was positively correlation between salivary ferritin and serum ferritin (P = 0.017). Hepcidin concentrations were relatively low in saliva.ConclusionsThese results suggest that iron overload and hepcidin inadequacy existed in CP with T2DM patients. Salivary ferritin might provide a reference for body iron load.Trial registration ChiCTR-ROC-17012780

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Section: Discussionmentioning

confidence: 99%

Serum and salivary ferritin and Hepcidin levels in patients with chronic periodontitis and type 2 diabetes mellitus

2018

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“…Hb, RBC counts, hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular Hb (MCH), mean corpuscular Hb concentration (MCHC), and erythrocyte sedimentation rate (ESR) (Hutter et al, 2001;Gokhale et al, 2010;Naik et al, 2010;Prakash et al, 2012;Chakraborty et al, 2014;Kolte et al, 2014;Patel et al, 2014;Khan et al, 2015;Latha et al, 2015;Anumolu et al, 2016;Carvalho et al, 2016;Nibal et al, 2019).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Four publications evaluated the effect of periodontitis on serum iron (Craig et al, 2003;Prakash et al, 2012;Thomas et al, 2013;Carvalho et al, 2016). Two articles on transferrin (Carvalho et al, 2016;Shirmohamadi et al, 2016), four references on ferritin (Prakash et al, 2012;Chakraborty et al, 2014;Latha et al, 2015;Carvalho et al, 2016), and two studies on hepcidin (Carvalho et al, 2016;Guo et al, 2018) were also included. Only one study assessing the effect of periodontitis on hepcidin in the GCF was excluded (Enhos et al, 2009).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Decreased Hemoglobin Concentration and Iron Metabolism Disorder in Periodontitis: Systematic Review and Meta-Analysis

Zhang

Cao

et al. 2020

Front. Physiol.

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Background: Periodontitis is a chronic inflammatory disease with a possible infectious component. Anemia of inflammation (AI) occurring in various chronic diseases alters the hemoglobin (Hb) concentration and iron status. Currently, the association between periodontitis and AI is still controversial. The aim of this study was to assess the alterations of the level of hematological parameters and iron metabolism markers in patients with or without periodontitis. Methods: Electronic databases (MEDLINE, EMBASE, and Cochrane) were searched to identify publications about anemia and periodontitis. Subgroup analyses regarding gender, extent of periodontitis, and sample size were performed using STATA 12.1. Results: Sixteen studies were included in this meta-analysis. Pooled results showed a decrease in Hb [standardized mean difference (SMD) = −0.76, 95% CI = (−1.15, −0.37)], red blood cell [SMD = −0.69, 95% CI = (−1.09, −0.29)], hematocrit [SMD = −1.13, 95% CI = (−1.69, −0.57)], mean corpuscular volume [SMD = −0.16, 95% CI = (−0.32, −0.01)], and mean corpuscular Hb [SMD = −0.16, 95% CI = (−0.28, −0.04)], but upregulation in erythrocyte sedimentation rate [SMD = 0.63, 95% CI = (0.06, 1.19)]. In addition, patients with periodontitis had a higher level of hepcidin [SMD = 0.59, CI = (0.05, 1.12)] and decreased level of transferrin [SMD = −4.6, CI = (−13.1, −3.90)], with high heterogeneity. Conclusion: This meta-analysis indicates that periodontitis decreases Hb concentration and disturbs the balance of iron metabolism, which confirms strength of association between periodontitis and the development tendency of AI, especially for severe periodontitis. More unbiased cohort studies with larger sample sizes are still warranted to make a definitive judgment in the future.

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“…In addition, it has been reported that elevated serum ferritin levels might be associated with the severity of periodontitis. 30 However, in a survey by Latha et al, 29 there was no difference in serum ferritin levels between the periodontitis group and the control group, which might be due to differences in race, sample size, and input standards.…”

Section: Discussionmentioning

confidence: 92%

Effect of non-surgical periodontal therapy on serum ferritin levels in postmenopausal women with chronic periodontitis

Faramarzi

Shirmohammadi

Khorramdel

et al. 2021

J Dent Res Dent Clin Dent Prospects

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Background. Ferritin is a positive acute phase protein (APP) in inflammation and chronic infections, including chronic periodontitis. Two key factors that can regulate ferritin expression are iron and pro-inflammatory cytokines. Serum ferritin levels increase after menopause, affecting women’s health. This study aimed to evaluate serum ferritin levels in postmenopausal women upon undertaking non-surgical periodontal treatment. Methods. In this cross-sectional study, blood samples of 38 postmenopausal women with chronic periodontitis were collected before any treatment. The serum ferritin levels and periodontal parameters, probing depth (PD), clinical attachment level (CAL), and gingival index (GI) were recorded at baseline and three months after non-surgical periodontal therapy. Wilcoxon test was used to compare serum ferritin levels before and after treatment. T-test was used for comparison of periodontal parameters, with a P value of ≤0.05 considered significant. Results. A decrease was observed in the serum ferritin level (from 108.55 mcg/L to 98.28 mcg/L) after treatment compared to baseline (P<0.001). Also, significant improvements in periodontal parameters were observed compared to the baseline (P<0.001). Conclusion. Based on the results, it can be concluded that non-surgical periodontal treatment significantly reduces serum ferritin levels in postmenopausal women with chronic periodontitis.

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Serum ferritin level and red blood cell parameters in healthy controls and chronic periodontitis patients

Cited by 8 publications

References 16 publications

Serum and salivary ferritin and Hepcidin levels in patients with chronic periodontitis and type 2 diabetes mellitus

Serum and salivary ferritin and Hepcidin levels in patients with chronic periodontitis and type 2 diabetes mellitus

Decreased Hemoglobin Concentration and Iron Metabolism Disorder in Periodontitis: Systematic Review and Meta-Analysis

Effect of non-surgical periodontal therapy on serum ferritin levels in postmenopausal women with chronic periodontitis

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