Serum ferritin in the diagnosis of cardiac and liver iron overload in thalassaemia patients real‐world practice: a multicentre study

Krittayaphong, Rungroj; Viprakasit, Vip; Saiviroonporn, Pairash; Wangworatrakul, Wipaporn; Wood, John C.

doi:10.1111/bjh.14776

Cited by 23 publications

(22 citation statements)

References 10 publications

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“…Serum ferritin can reliably predict cardiac iron overload when levels are .2485 ng/mL. 2 The manifestation of his abdominal magnetic resonance imaging, a significant decrease in signal intensity on T2-weighted images in the liver parenchyma, is consistent with iron overload. Cardiac iron deposition can result in cardiomyopathy, arrhythmia, and heart failure.…”

Section: Discussionmentioning

confidence: 99%

Type 1 Brugada phenotype induced by cardiac iron overload after blood transfusion

Sun

Liu

2020

HeartRhythm Case Reports

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Section: Discussionmentioning

confidence: 99%

Type 1 Brugada phenotype induced by cardiac iron overload after blood transfusion

Sun

Liu

2020

HeartRhythm Case Reports

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“…Documentation of ferritin as risk for fibrosis is important finding of our study with implications in patients which are at high risk to develop increased ferritin, such as patients that require repeated transfusions. 9,16 Increase in fibrosis score/stage lead to many complications of cirrhosis like portal hypertension, ascites and related further complications. It is documented that CHC is a major cause of cirrhosis and hepatocellular carcinoma (HCC) around the world.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Serum Ferritin Levels and Liver Stiffness measured by Fibroscan in patients with Chronic Hepatitis C

2020

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Objective: To determine correlation between transient elastography values with serum ferritin and duration of infection in patients of hepatitis C. Methods: A cross-sectional study was conducted at medical units of Civil Hospital, Karachi. The study protocol was approved by the Research Evaluation Unit of College of Physician and Surgeon Pakistan (CPSP). Patients fulfilling inclusion criteria were included after taking informed consent. Serum ferritin levels were tested by standard laboratory procedures and transient elastography by fibroscan. Regression analysis was done to see correlation of ferritin with transient elastography and duration of HCV. Results: Over all 120 patients fulfilling the selection criteria were selected after informed consent. These included 68 (56.7%) male & 52 (43.3%) female. Significant differences in ferritin levels by Fibrosis stages were observed by ANOVA (df = 3; F =12.768; p = <0.001). Serum ferritin showed linear pattern across Fibrosis stages (F = 33.948; p = <0.001). Regression analysis of ferritin and duration of HCV showed significant impact on TE scores (r2 = 0.317). Conclusions: There is significant correlation between serum ferritin and duration of HCV with TE scores. doi: https://doi.org/10.12669/pjms.36.3.1288 How to cite this:Latif S, Kalam Q, Zuberi BF. Correlation between Serum Ferritin Levels and Liver Stiffness measured by Fibroscan in patients with Chronic Hepatitis C. Pak J Med Sci. 2020;36(3):---------. doi: https://doi.org/10.12669/pjms.36.3.1288 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…From the data in (Table1), we found that the level of calcium was less than normal in the patients because of the precipitation of iron on and in the parathyroid gland, which will reduce the secretion of parathyroid hormone. This hormone is the main factor that controls the level of calcium and phosphorus ion iron over load (7) . This occurs in large numberof patient of thalassemia as a result of increase absorption of iron in gastrointestinal tract and multiple transfusion of blood and inappropriate iron chelation therapy and this will lead to accumulation of iron in liver, endocrine glands, and heart eventually (8,9).…”

Section: Discussionmentioning

confidence: 99%

Iron Overload Complication in Thalassemia Patients

Khdsayer T. Rotha

2020

Indian Journal of Forensic Medicine & Toxicology

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Thalassemia is an inherited disorder. All the types of thalassemia that require continuous blood transfusion, lead to increase of absorption of iron, which will lead to iron overload eventually. The precipitation of iron will affect many organs in the human body, and can be measured by S-ferritin.In this study, patients with all kinds of thalassemia that require multiple blood transfusion, have been evaluated for the level of ferritin and iron overload as well as other complications such as liver diseases, heart diseases, bone disorders, and hormone disorders. One-hundred patients have been selected randomly with different ages to evaluate the serum ferritin, calcium level, liver enzymes, and Hb by use enzyme linked assay. This study confirms the use of chelation therapy to remove the iron overload.

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Serum ferritin in the diagnosis of cardiac and liver iron overload in thalassaemia patients real‐world practice: a multicentre study

Cited by 23 publications

References 10 publications

Type 1 Brugada phenotype induced by cardiac iron overload after blood transfusion

Type 1 Brugada phenotype induced by cardiac iron overload after blood transfusion

Correlation between Serum Ferritin Levels and Liver Stiffness measured by Fibroscan in patients with Chronic Hepatitis C

Iron Overload Complication in Thalassemia Patients

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