Serum ferritin in juvenile chronic polyarthritis.

Craft, A. W.; Eastham, E J; Bell, J I; Brigham, Kenneth L.

doi:10.1136/ard.36.3.271

Cited by 19 publications

(4 citation statements)

References 11 publications

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“…These new findings suggest that the interaction between GAPDH and transferrin might determine how they are associated with the disease process. Other studies have confirmed an upregulation of serum transferrin and ferritin in active JIA disease 71–74. Taken together, these findings suggest that the interaction of Fe 2+ ‐bound transferrin with GAPDH could reveal cryptic epitopes in both transferrin and GAPDH.…”

Section: Discussionsupporting

confidence: 64%

Proteomic analysis of circulating immune complexes in juvenile idiopathic arthritis reveals disease‐associated proteins

Low

Chauhan

Gibson

et al. 2009

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Juvenile idiopathic arthritis reflects a group of clinically heterogeneous arthritides hallmarked by elevated concentrations of circulating immune complexes. In this study, the circulating immune complex proteome was examined to elucidate disease-associated proteins that are overexpressed in patients with an aggressive, and at times destructive, disease phenotype. To solve this proteome, circulating immune complexes were isolated from the sera of patients with chronic, erosive or early-onset, aggressive disease and from patients in medical remission or healthy controls subsequent to protein separation by 2-DE. Thirty-seven protein spots were overexpressed in the circulating immune complexes of the aggressive disease groups as compared to controls, 28 of which have been confidently identified to date. Proteolytic fragments of glyceraldehyde-3-phosphate dehydrogenase, serotransferrin, and α-1-antitrypsin have been identified among others. In total, these 28 putative disease-associated proteins most definitely contribute to immune complex formation and likely have a significant role in disease etiology and pathogenesis. Moreover, these proteins represent markers of aggressive disease, which could aid in diagnosis and management strategies, and potential therapeutic targets to prevent or control disease outcome. This is the first in-depth analysis of the circulating immune complex proteome in juvenile idiopathic arthritis.

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Section: Discussionsupporting

confidence: 64%

Proteomic analysis of circulating immune complexes in juvenile idiopathic arthritis reveals disease‐associated proteins

Low

Chauhan

Gibson

et al. 2009

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“…In rheumatoid patients, Craft et al (10) showed that s-ferritin reflected disease activity fairly accurately in patients with juvenile rheumatoid arthritis, and Blake & Bacon (8) showed that s-ferritin levels were high in patients with active synovitis and especially high in patients with systemic manifestations. However, the concept of s-ferritin as an acute-phase reactant may require modification.…”

Section: T M~r K Hansen Et Almentioning

confidence: 98%

Serum Ferritin and the Assessment of Iron Deficiency in Rheumatoid Arthritis

Hansen

et al. 1983

Scandinavian Journal of Rheumatology

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In order to evaluate the diagnostic and pathogenetic importance of s-ferritin and p-lactoferrin in the anemia of rheumatoid arthritis (RA), 38 patients were examined. Twenty-one out of 38 randomly selected anemic patients with classical or definite RA had iron deficiency, as estimated from the iron content in stained bone marrow aspiration. S-ferritin concentrations below 60 micrograms per litre had sensitivity and a specificity for iron deficiency of 86% and 88%, respectively, which was much better than such commonly used variables as s-iron, p-transferrin, MCV, and MCHC. Although this cut-off level is higher than in patients without inflammatory disease, s-ferritin was not correlated to disease activity. In 7 out of 8 patients, the s-ferritin level rose during iron therapy. P-lactoferrin values were within the normal range and did not vary with the anemia or with disease activity. Thus p-lactoferrin appears to be of no pathogenetic importance in the anemia of RA.

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“…Serum ferritin is in equilibrium with tissue ferritin, and has been found to give an accurate indication of tissue iron stores in normal subjects and in patients with iron deficiency and iron 0032-5473/83/0900-0543 $02.00 © 1983 The Fellowship of Postgraduate Medicine overload, patients with simple iron deficiency having serum ferritin values below 12 ,ug/litre . However, ferritin levels are known to be raised by inflammation (Lipschitz, Cook and Finch, 1974) so this value is inappropriate for patients with many chronic disorders; for example, serum ferritin has been found to be raised and to correlate closely with disease activity in children with juvenile chronic arthritis (Craft et al, 1977). Bentley and Williams (1974) studied a large series of patients with anaemia of RA and although they found a close correlation between serum ferritin and stainable marrow iron, the mean ferritin in the 13 patients with absent marrow iron stores was 38 ,ug/litre and only 3 had values below 12 ,ug/litre.…”

Section: Laboratory Features and Differential Diagnosismentioning

confidence: 99%

The anaemia of chronic disorders

Samson¹

1983

Postgraduate Medical Journal

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Chronic disease can cause anaemia in a number of ways, such as poor nutrition, chronic blood loss and as a result of drug therapy. Leaving aside these factors, however, there is a specific type of anaemia associated with chronic infection, chronic inflammatory diseases and malignancy. This anaemia is characterised by decreased plasma iron and iron-binding capacity in the presence of normal or increased reticulo-endothelial iron stores, and has been termed the anaemia of chronic disorders (Cartwright and Lee, 1971). Although the anaemia of chronic disorders is one of the most common anaemias encountered in medical practice, its aetiology remains unclear and treatment unsatisfactory.

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Serum ferritin in juvenile chronic polyarthritis.

Cited by 19 publications

References 11 publications

Proteomic analysis of circulating immune complexes in juvenile idiopathic arthritis reveals disease‐associated proteins

Proteomic analysis of circulating immune complexes in juvenile idiopathic arthritis reveals disease‐associated proteins

Serum Ferritin and the Assessment of Iron Deficiency in Rheumatoid Arthritis

The anaemia of chronic disorders

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