Serum Ferritin Concentration Predicts Mortality in Patients with Hepatitis B Virus-related Acute on Chronic Liver Failure

Low transferrin and high ferritin concentrations are associated with worse outcome in acute liver failure

“…Another study on cirrhotic patients showed that serum ferritin was associated with markers of liver insufficiency, inflammation and circulatory dysfunction . High ferritin levels were also associated with increased 3‐month mortality in patients with acute‐on chronic liver failure due to hepatitis B . Transferrin levels were decreased in alcoholic cirrhosis and could serve as a serum marker for predicting advanced liver fibrosis in chronic hepatitis B and C .…”

“…26 High ferritin levels were also associated with increased 3-month mortality in patients with acute-on chronic liver failure due to hepatitis B. 10 Transferrin levels were decreased in alcoholic cirrhosis 13 and could serve as a serum marker for predicting advanced liver fibrosis in chronic hepatitis B and C. 14,15 Ferritin has been evaluated in an acute hepatitis setting as well. Indeed, serum ferritin levels were significantly higher in fulminant hepatic failure and severe hepatitis than in acute hepatitis.…”

“…Serum ferritin has been evaluated as a prognostic outcome marker in many clinical settings including alcoholic, non‐alcoholic and viral hepatitis, cirrhosis and acute‐on‐chronic liver failure . High ferritin and low transferrin saturation before liver transplantation were independent risk factors for long‐term mortality following liver transplantation for chronic end‐stage liver disease .…”

IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections

“…However, during the acute stages of an Epstein-Barr virus (EBV) infection, plasma IL-18 concentrations can easily exceed 1,000 pg/mL, with median ferritin up to 431 μg/L [47]. IL-18 and ferritin are also strongly induced during chronic hepatitis B and C virus infections [48–51]. The human immunodeficiency virus (HIV) disease is another viral infection that has been characterized by increased circulating levels of both IL-18 and ferritin.…”

Letter: high ferritin to haemoglobin ratio is related to early mortality in patients with alcoholic hepatitis

“…Letter: high ferritin to haemoglobin ratio is related to early mortality in patients with alcoholic hepatitis EDITORS, We read with interest the review by Czaja 1 about the association of hyperferritinaemia with early mortality in both decompensated cirrhosis 1 and acute-on-chronic liver failure (ACLF). 2 Serum ferritin is an acute phase protein and its production is stimulated by proinflammatory cytokines TNF-alpha and IL-1beta 3 and the presence of oxidative stress. 4 Alcoholic hepatitis (AH) is a severe form of alcoholic liver disease associated with poor outcome.…”