Serum ferritin and vitamin D levels in premature hair graying of college student at the Universitas Sumatera Utara area

Anggraini, Dwi Rita; Feriyawati, Lita; Hidayat,

doi:10.1088/1755-1315/305/1/012009

Cited by 7 publications

(8 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In accordance, several previous studies reported slightly lower mean serum vitamin D level in PHG patients compared to controls without statistical significance 11,19 . Furthermore, Anggraini and Feriyawati 6 measured serum vitamin D among 100 PHG patients. They revealed low serum vitamin D levels among PHG patients but also without statistical significance.…”

Section: Discussionsupporting

confidence: 83%

“…Many studies have reported significantly lower serum ferritin levels in PHG patients compared to controls 10,11,19 . However, measurement of serum ferritin levels among 100 PHG patients in Anggraini and Feriyawati 6 revealed 91 patients had normal serum ferritin, only six patients had low ferritin levels while three patients had high serum ferritin. Higher values of serum ferritin which were recorded in their study, could be attributed to exclusion of any female in the reproductive age group with excessive menstrual losses.…”

Section: Discussionmentioning

confidence: 95%

“…The exact etiology of premature hair graying (PHG) is unknown; however, it is suggested to occur in genetically predisposed people exposed to various environmental factors 4 . Moreover, deficiency of serum vitamin D, vitamin B12, calcium, magnesium, ferritin, and many other trace elements were suggested to be associated with PHG 5,6 . Unfortunately, the exact pathological link between these biomarkers is still to be evaluated.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Epidemiological and biochemical factors (serum ferritin and vitamin D) associated with premature hair graying in Egyptian population

Elhusseiny

Alrgig

Fattah

2020

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Hair graying (canities) is one of the natural aging processes. Although it is generally not a medical problem, it greatly concerns many people for aesthetic reasons. 1 The age of normal occurrence of physiological graying of hairs varies in different races; age of 34.2 ± 9.6 years in white races, 43.9 ± 10.3 years in blacks, and between 30 and 39 years in Japanese population. 2 There is no available reference age range for physiological graying for Egyptian subcontinent.

show abstract

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiological and biochemical factors (serum ferritin and vitamin D) associated with premature hair graying in Egyptian population

Elhusseiny

Alrgig

Fattah

2020

J of Cosmetic Dermatology

View full text Add to dashboard Cite

show abstract

“…Krugluger et al (2011) informed that vitamin B12 and minerals play a role in pigmentation and hair growth [20], while another study showed that premature canities were associated with deficiency calcium and vitamin D3. The pilot study showed decreased vitamin D levels, but serum ferritin was normally at PHG [21], [22].…”

Section: Discussionmentioning

confidence: 91%

Biomarker of Oxidative Stress in Premature Hair Graying at Young Age

Anggraini

Feriyawati

Sitorus

et al. 2021

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: Gray hair is a physiological process of aging that occurs in everyone. Premature hair graying (PHG) is the term when early hair gray at an unusual age. The causes of PHG are multifactorial, genetic, nutritional, and environmental, including oxidative stress. Free radicals caused interference with cellular responses that cause direct damage to various proteins and DNA in the long term. The body’s defense mechanisms likely antioxidant enzymes, including catalase, glutathione peroxidase (GPx), and superoxide dismutase (SOD) was activated against free radicals. AIM: We aimed to evaluate markers of oxidative stress and associated with severe graying at young age. MATERIALS AND METHODS: We recruited consecutive 40 respondents with PHG and healthy controls, male sex and aged <25 years. The severe graying was graded with total of gray hair. The serum samples were collected to detect oxidative stress markers through malondialdehyde (MDA), SOD, catalase, and GPx measurement with enzyme-linked immunosorbent assay. RESULTS: Serum MDA concentration was higher but not significantly (p > 0.05), while serum SOD, catalase, and GPx level, indicators of antioxidant were significantly lower (p < 0.001, p = 0.017 and p < 0.001, respectively) in PHG compared to controls. The correlation between oxidative stress and graying severity was not significant (p > 0.05), but the association between onset and severity of graying was significant (p < 0.001). CONCLUSIONS: Respondents with PHG had increased of pro-oxidants and decreased of antioxidants compared than controls. The severity of graying is equivalent to the level of oxidative stress. The supplement of antioxidants is likely recommended in PHG.

show abstract

“…Anggraini et al also had fair quality, because they did not explain the existence of informed consent and did not have a control group as a comparison. Both studies used a cross-sectional study [27]. Tables 2 and 3 show the assessments of the quality of the included studies.…”

Section: Quality Of Study In Included Studiesmentioning

confidence: 99%

Serum Micronutrient Levels In Premature Canities: A Systematic Review and Meta-analysis.

Camelia¹,

Malik²,

Riyanto³

et al. 2021

Dermatol Res

View full text Add to dashboard Cite

Background: Premature canities, also known as premature graying of hair, is the graying of hair before 20 years old in Caucasians, before 25 years old in Asians, and before 30 years old in African–Americans. The risk factors for premature canities are multifactorial. The role of micronutrient deficiency has long been suggested to be involved in the etiopathogenesis of premature canities. The management of premature canities remains limited and far from satisfactory; hence, knowing what vitamins and minerals can help in treating premature canities is vital. Aim: This study aims to analyze serum vitamin B12, iron, ferritin, copper, calcium, and zinc levels in premature canities. Methods: The MEDLINE/PubMed electronic database, Cochrane library, ClinicalTrials.gov, EBSCO, Scopus, ProQuest, Cambridge Core, reference lists, conference proceedings, and researchers in fields of eligible studies were searched. Twelve studies (n = 1791 subjects) were included in qualitative analysis of which nine studies (n = 1381 subjects) were included in meta-analysis. Serum levels of micronutrients (vitamin B12, iron, ferritin, copper, calcium, and zinc) were compared in the premature canities and nonpremature canities groups. Result: Pooling of data using fixed-effects model found the overall effect mean difference serum vitamin B12 level was −0.697 ± 0.105 (95% CI = −0.904 to −0.490), p < 0.001. The overall mean difference serum iron level was 0.146 ± 0.105 (95% CI = −0.058 to 0.350), p = 0.161. The overall mean difference serum ferritin level was 0.720 ± 0.071 (95% CI = 0.585 to 0.854), p < 0.001. The overall mean difference serum copper level was 0.230 ± 0.118 (95% CI = −0.003 to 0.463, p = 0.053. The overall mean difference serum calcium level was −0.443 ± 0.114 (95% CI = −0.655 to −0.212), p < 0.001. The overall mean difference serum zinc level was −0.104 ± 0.138 (95% CI = 0.377 to 0.170, p = 0.457. Qualitative analysis showed that vitamin B12 plays an important role in DNA synthesis in the proliferation of hair follicle cells and in melanogenesis. Iron, ferritin, copper, calcium, and zinc also play important roles in stabilizing and increasing tyrosinase activity in several stages of the melanogenesis process. Conclusion: The meta-analysis showed that serum levels of vitamin B12, ferritin, and calcium were significantly lower in premature canities. Although the lower serum iron, copper, and zinc levels were not significantly different in premature canities compared with nonpremature canities. Qualitative analysis found that deficiency of vitamin B12, iron, ferritin, zinc, copper, and calcium can affect the physiology of hair melanogenesis that causing premature canities.

show abstract

Serum ferritin and vitamin D levels in premature hair graying of college student at the Universitas Sumatera Utara area

Cited by 7 publications

References 10 publications

Epidemiological and biochemical factors (serum ferritin and vitamin D) associated with premature hair graying in Egyptian population

Epidemiological and biochemical factors (serum ferritin and vitamin D) associated with premature hair graying in Egyptian population

Biomarker of Oxidative Stress in Premature Hair Graying at Young Age

Serum Micronutrient Levels In Premature Canities: A Systematic Review and Meta-analysis.

Contact Info

Product

Resources

About