Serum Ferritin and Ageing

Casale, Giorgi; Bonora, Carlo; Migliavacca, A; Zurita, Ivan E.; Nicola, P

doi:10.1093/ageing/10.2.119

Cited by 71 publications

(33 citation statements)

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“…Depending our findings, serum ferritin concentrations were found similar in all groups, although serum transferrin levels of the ACD and IDA groups were significantly different when compared with the healthy controls. Serum levels of ferritin increases in chronic disorders and in malignancy which are more frequent in elderly (Loria et al 1979) and also has tendecy to increase with age (Casale et al 1981;Witte 1991). However, acute phase responses make the interpretation of the laboratory data difficult, given that both serum ferritin and serum transferrin are acute phase reactants, the former increases and latter decreases in acute inflammation (Leggett et al 1990;Coenen et al 1991;Witte 1991).…”

Section: Discussionmentioning

confidence: 99%

Soluble Transferrin Receptor and Soluble Transferrin Receptor-Ferritin Index for Evaluation of the Iron Status in Elderly Patients

Genç

Erten

Karan

et al. 2004

Tohoku J. Exp. Med.

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We aimed to evaluate the diagnostic values of soluble transferrin receptor (sTfR) concentration, transferrin-ferritin index (soluble transferrin receptor concentration/log ferritin), ferritin levels and other related parameters in geriatric patients with anemia of chronic disease (ACD) and iron deficiency (IDA). Forty-four elderly subjects (median age 73 ) and twenty healthy subjects (median age 49 [44][45][46][47][48][49][50][51][52][53][54][55][56]) were enrolled into this study, divided into four groups: twenty middle aged healthy subjects (group A), fifteen elderly patients with IDA (group B), fourteen elderly patients with ACD (group C) and fifteen nonanemic geriatric subjects (group D). Hemoglobin, mean corpuscular volume, serum iron concentration and transferrin saturation levels of the patients in IDA group were found significantly lower than those in both non-anemic group and healthy subjects. Serum sTfR concentrations of the patients in IDA group were significantly higher than those in non-anemic geriatric group, ACD group and healthy subjects. Transferrin-ferritin index of the patients with IDA was significantly higher than that in non-anemic geriatric and ACD group. Serum ferritin levels of the patients in IDA group did not show any differences when compared with the other groups. Serum ferritin was highly specific for IDA (95%) when compared with ACD, although its sensitivity was low (38%). STfR values were negatively correlated with both transferrin and ferritin levels (p=0.042 r=−0.40; and p=0.034 r= −0.41, respectively). In conclusion, serum soluble transferrin receptor and transferrin-ferritin index may be used together with serum ferritin to distinguish the iron deficiency state in the elderly.soluble transferrin receptor; transferrin-ferritin index; iron deficiency; elderly

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Section: Discussionmentioning

confidence: 99%

Soluble Transferrin Receptor and Soluble Transferrin Receptor-Ferritin Index for Evaluation of the Iron Status in Elderly Patients

Genç

Erten

Karan

et al. 2004

Tohoku J. Exp. Med.

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“…In menopausal women, serum ferritin in creases to a value slightly inferior to that of men [4,7,8,26], Moreover, several authors, performing post-mortem examinations, have observed that hepatic stores of women were obviously greater after menopause [5,6,24], In this study, women have been given iron intakes theoretically sufficient to cover their losses. 1 month of iron supplementa tion improved their iron status.…”

Section: Discussionmentioning

confidence: 79%

“…Menstruating women's serum ferritin val ues are 2 or 3 times lower than those of men, indicating a difference in size of hepatic iron stores between men and women [1,4,8,19,20,26,31]. This difference and the great prevalence of iron deficiency in menstruating women point out the problem of serum ferri tin reference values and of the definition of normal iron stores in menstruating women.…”

Section: Discussionmentioning

confidence: 99%

Effects of Iron Supplementation on Serum Ferritin and Other Hematological Indices of Iron Status in Menstruating Women

Herçberg¹,

Galán²,

Soustre³

et al. 1985

Ann Nutr Metab

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Serum ferritin, hemoglobin, serum iron and transferrin iron-binding capacity were evaluated in 107 healthy female students. 21 women had a serum ferritin of 12 µg/l or less, corresponding to an exhaustion of body iron stores. After 1 month of iron supplementation, significant increase of hemoglobin concentration and decrease of total iron-binding capacity were observed. Mean serum ferritin had increased from 24 to 41 µg/l, and all women had a serum ferritin above 12 µg/l. 1 month after the end of the trial, serum ferritin fell significantly. This study points out the problem of serum ferritin reference values and the definition of normal iron stores in menstruating women.

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“…Previously published reports have used serum ferritin levels to diagnose IDA, but the cutoff levels were different in the various studies. The interpretation of the serum ferritin level in older adults is sometimes complicated because its level increases with age and with concomitant chronic illnesses [5, 6]. Therefore, we measured the soluble transferrin receptor (sTfR), which is not influenced by ageing or chronic diseases [7, 8], and we calculated the ratio of sTfR to the log ferritin level (sTfR-F index) to make the test more specific.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Iron Deficiency Anemia in Community-Dwelling Older Persons as Measured by the Transferrin Receptor-Ferritin Index

Choi¹,

Park²,

Choi³

et al. 2005

Acta Haematol

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Serum Ferritin and Ageing

Cited by 71 publications

References 0 publications

Soluble Transferrin Receptor and Soluble Transferrin Receptor-Ferritin Index for Evaluation of the Iron Status in Elderly Patients

Soluble Transferrin Receptor and Soluble Transferrin Receptor-Ferritin Index for Evaluation of the Iron Status in Elderly Patients

Effects of Iron Supplementation on Serum Ferritin and Other Hematological Indices of Iron Status in Menstruating Women

Prevalence of Iron Deficiency Anemia in Community-Dwelling Older Persons as Measured by the Transferrin Receptor-Ferritin Index

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