Serum Fatty Acids and Risk of Cutaneous Melanoma: A Population-Based Case-Control Study

Malagoli, Carlotta; Iacuzio, Laura; Crespi, Catherine M.; Sieri, Sabina; Marmiroli, Sandra; Pellacani, Giovanni; Venturelli, Elisabetta

doi:10.1155/2013/659394

Cited by 14 publications

(12 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Melanoma. Observational study findings are inconclusive regarding the association of PUFAs and melanoma risk (56,57). Our meta-analyzed results combining the estimates from Liyanage and colleagues (38) suggested that there is no association between PUFAs and melanoma after the adjustment for multiple testing (AA: OR, 1.03; 95% CI, 1.00-1.07; Supplementary Table S6).…”

Section: Discussionmentioning

confidence: 73%

Mendelian Randomization Study for Genetically Predicted Polyunsaturated Fatty Acids Levels on Overall Cancer Risk and Mortality

Liyanage

Ong

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background: Observational studies evaluating the link between polyunsaturated fatty acids (PUFA) and cancers have yielded mixed findings. We used Mendelian randomization (MR) to evaluate whether genetic evidence supports a causal role for PUFAs on overall cancer outcomes.Methods: We identified genetic instruments for six PUFAs from previous literature and evaluated their association with overall cancer risk (46,155 cases, 270,342 controls) and cancer mortality (6,998 deaths, 270,342 controls) among the UK Biobank cohort. We used the inverse variance weighted model to combine SNP estimates, and derived log (OR) estimates per SD change in each PUFA.Results: None of the six PUFAs showed association with overall cancer risk or mortality, with narrow confidence interval (CI) ruling out all but very small effects, for example, arachidonic acid (AA) overall cancer risk (OR, 1.02; 95% CI, 1.00-1.03). Sex-specific analysis revealed no associations except a-linolenic acid for potentially reducing cancer risk in men (OR, 0.92; 95% CI, 0.86-0.98; P ¼ 0.02); however, this was nonsignificant after multiple testing correction. From individual cancers, only colorectal cancer showed evidence for a causal association for higher AA levels (OR, 1.05; 95% CI, 1.03-1.07), with similar results for the other correlated PUFAs.Conclusions: Our study provides no support for the hypothesis that PUFAs reduce overall cancer risk or mortality. Higher AA levels increased the risk for colorectal cancer.Impact: Our well-powered MR study provides robust causal inferences for the PUFAs on overall cancer risk and mortality. Future larger studies are warranted to replicate the individual cancer findings.

show abstract

Section: Discussionmentioning

confidence: 73%

Mendelian Randomization Study for Genetically Predicted Polyunsaturated Fatty Acids Levels on Overall Cancer Risk and Mortality

Liyanage

Ong

et al. 2019

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…Details of our case-control study on dietary risk factors for cutaneous melanoma in the population of five provinces of the Emilia Romagna region, northern Italy (population about 3 000 000), have been provided elsewhere (17)(18)(19) . In brief, during 2005-2006, we attempted to recruit all patients with newly diagnosed cutaneous malignant melanoma residing in the provinces of Bologna, Ferrara, Modena, Parma and Reggio Emilia and attending the local dermatological clinics.…”

Section: Methodsmentioning

confidence: 99%

Glycaemic index, glycaemic load and risk of cutaneous melanoma in a population-based, case–control study

et al. 2017

Self Cite

View full text Add to dashboard Cite

Glycaemic index (GI) and glycaemic load (GL) are indicators of dietary carbohydrate quantity and quality and have been associated with increased risk of certain cancers and type 2 diabetes. Insulin resistance has been associated with increased melanoma risk. However, GI and GL have not been investigated for melanoma. We present the first study to examine the possible association of GI and GL with melanoma risk. We carried out a population-based, case-control study involving 380 incident cases of cutaneous melanoma and 719 age- and sex-matched controls in a northern Italian region. Dietary GI and GL were computed for each subject using data from a self-administered, semi-quantitative food frequency questionnaire. We computed the odds ratio (OR) for melanoma according to quintiles of distribution of GL and GL among controls. A direct association between melanoma risk and GL emerged in females (OR 2·38; 95 % CI 1·25, 4·52 for the highest v. the lowest quintile of GL score, P for trend 0·070) but not in males. The association in females persisted in the multivariable analysis after adjusting for several potential confounders. There was no evidence of an association between GI and melanoma risk. GL might be associated with melanoma risk in females.

show abstract

“…We have also previously reported a marginal increase in SCC risk with greater arachidonic acid intake and a decrease in BCC risk with increasing total omega-6 intake (12). However, a study of over 40,000 American male health professionals failed to find a link between omega-3 intake and BCC risk (13), whereas an Italian case-control study found a positive association of serum docosapentaenoic acid with melanoma risk only in men (14). The present study aimed to investigate associations between plasma phospholipid levels of omega-3 and omega-6 PUFA, and the development of BCC and SCC.…”

Section: Introductionmentioning

confidence: 87%

Plasma Omega-3 and Omega-6 Concentrations and Risk of Cutaneous Basal and Squamous Cell Carcinomas in Australian Adults

Wallingford

Hughes

Green

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Laboratory-based evidence suggests that omega-3 and omega-6 polyunsaturated fatty acids may affect skin photocarcinogenesis, but epidemiologic evidence is inconsistent. In 1,191 White Australian adults, we prospectively investigated associations between baseline plasma concentrations of omega-3 and omega-6 fatty acids and cutaneous basal cell carcinomas (BCC) and squamous cell carcinomas (SCC). Relative risks (RR) and 95% confidence intervals (CI) were estimated on the basis of number of histologically confirmed tumors diagnosed during follow-up (1997-2007). Plasma eicosapentaenoic acid (EPA) concentrations and omega-3/-6 ratio showed significant inverse associations with SCC tumors, comparing higher tertiles with the lowest, in age-and sex-adjusted models (P trend ¼ 0.02 and 0.03, respectively) which weakened after adjustment for past sun exposure. Associations between EPA and SCC were stronger among participants with a history of skin cancer at baseline (n ¼ 378; highest vs. lowest tertile: RR ¼ 0.50; 95% CI, 0.28-0.92; P trend ¼ 0.01). Total omega-6 was inversely associated with BCC tumors in multivariate models (P ¼ 0.04; highest vs. lowest tertile: RR ¼ 0.71; 95% CI, 0.51-0.99), and more strongly in the subgroup with past skin cancer. Linoleic and linolenic acids were also inversely associated with BCC occurrence in this subgroup. When fatty acids were analyzed as continuous variables, however, there was no evidence of any linear or nonlinear associations. This study provides some support for reduced skin cancer risk with high plasma concentrations of omega-3 and omega-6 fatty acids, but results depended on how fatty acid data were modeled. Further investigation of these associations in larger datasets is needed. Cancer Epidemiol Biomarkers Prev; 22(10); 1900-5. Ó2013 AACR.

show abstract

Serum Fatty Acids and Risk of Cutaneous Melanoma: A Population-Based Case-Control Study

Cited by 14 publications

References 29 publications

Mendelian Randomization Study for Genetically Predicted Polyunsaturated Fatty Acids Levels on Overall Cancer Risk and Mortality

Mendelian Randomization Study for Genetically Predicted Polyunsaturated Fatty Acids Levels on Overall Cancer Risk and Mortality

Glycaemic index, glycaemic load and risk of cutaneous melanoma in a population-based, case–control study

Plasma Omega-3 and Omega-6 Concentrations and Risk of Cutaneous Basal and Squamous Cell Carcinomas in Australian Adults

Contact Info

Product

Resources

About