Serum fatty acid profile in psoriasis and its comorbidity

Myśliwiec, Hanna; Baran, Anna; Harasim-Symbor, Ewa; Myśliwiec, Piotr; Milewska, Anna Justyna; Chabowski, Adrian; Flisiak, Iwona

doi:10.1007/s00403-017-1748-x

Cited by 55 publications

(60 citation statements)

References 36 publications

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“…Even though the total FA concentration was similar to that in the control group, there were significant differences in individual acids. A significant rise in the n-6/n-3 ratio and a reduction in omega-3 PUFAs were observed [42]. A positive correlation was identified between PASI and the ratio of n-6/n-3 PUFAs, and a negative correlation was found between PASI and eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and n-3 PUFAs.…”

Section: Fatty Acidsmentioning

confidence: 95%

“…A number of studies have shown a decrease in the total concentration of phospholipids, phosphatidylethanolamine, lecithin, linolenic acid, and docosatetraenoic and docosapentaenoic acids [9,41]. Some studies demonstrate an increase in some fractions, such as palmitic acid and palmitooleic acid, while others show no differences [9,27,42]. An increase in CER, both in skin lesions and in the serum of patients with psoriasis, has been shown, however only in association with the severe course of the disease.…”

Section: Lipidy W Surowicy Cholesterole Trójglicerydy I Apolipoproteinymentioning

confidence: 99%

“…W niektórych pracach odnotowano wzrost pewnych frakcji, np. kwasu palmitynowego, palmitooleinowego, w innych nie było różnic [9,27,42]. Wykazano wzrost CER zarówno w zmianach skórnych, jak i w surowicy pacjentów z łuszczycą, ale wyłącznie w przypadkach o ciężkim przebiegu.…”

Section: Fosfolipidyunclassified

“…The supply of saturated fatty acids (SFA) is commonly known to increase the risk of CVD, and a diet rich in polyunsaturated fatty acids (PUFAs) and monounsaturated fatty acids (MUFAs) is associated with a lower rate of immunometabolic diseases [42]. The most recent study in patients with psoriasis has shown marked abnormalities in the FA profile.…”

Section: Fatty Acidsmentioning

confidence: 99%

“…Also, significantly higher SFA and lower PUFA levels were found in men that in women. The SFA/UFA ratio increased along with the duration of the disease, which proves indirectly that the risk of developing metabolic disorders rises in proportion to the duration of psoriasis [42]. The importance of supplementation with omega-3 fatty acids in patients with psoriasis is discussed below.…”

Section: Fatty Acidsmentioning

confidence: 99%

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The role of lipids in psoriasis

Baran¹,

Kiluk²,

Myśliwiec³

et al. 2017

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Psoriasis, affecting 2-4% of the world's population, is a chronic recurrent inflammatory skin disease. Its multifactorial aetiopathogenesis consists of, for example, abnormal epidermal proliferation, immune disturbances, and genetic, psychosomatic, environmental and hormonal factors. Psoriasis is also considered to be a systemic disorder closely associated with cardiovascular diseases, atherosclerosis, diabetes mellitus, obesity or metabolic syndrome. Lipids have a variety of biological functions. They participate not only in energy storage and expenditure or the formation of cell membranes, but also in inflammatory and metabolic signalling pathways. Disturbances in their homeostasis lead to the development of immunometabolic disorders, including psoriasis. Based on the available literature, this article presents selected molecular and clinical aspects involved in the multidirectional effect of lipids on psoriasis.streszczenie Łuszczyca, która występuje u 2-4% populacji na świecie, jest przewlekłą i nawrotową chorobą zapalną skóry. Na jej wieloczynnikową etiopatogenezę składają się m.in. nieprawidłowa proliferacja naskórka, zaburzenia immunologiczne, czynniki genetyczne, psychosomatyczne, środowiskowe i hormonalne. Łuszczyca jest również uznawana za schorzenie ogólnoustrojowe, związane z chorobami układu sercowo--naczyniowego, miażdżycą, cukrzycą, otyłością i zespołem metabolicznym. Lipidy pełnią wiele biologicznych funkcji, biorą udział nie tylko w magazynowaniu i wydatkowaniu energii, tworzeniu błon komórko-wych, lecz także w zapalnych i metabolicznych szlakach sygnałowych. Zaburzenia ich homeostazy powodują rozwój schorzeń immunometabolicznych, w tym łuszczycy. W niniejszej pracy przedstawiono na podstawie dostępnego piśmiennictwa wybrane aspekty molekularne i kliniczne wielokierunkowego wpływu lipidów na łuszczycę.

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Section: Fatty Acidsmentioning

confidence: 95%

Section: Lipidy W Surowicy Cholesterole Trójglicerydy I Apolipoproteinymentioning

confidence: 99%

Section: Fosfolipidyunclassified

Section: Fatty Acidsmentioning

confidence: 99%

Section: Fatty Acidsmentioning

confidence: 99%

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The role of lipids in psoriasis

Baran¹,

Kiluk²,

Myśliwiec³

et al. 2017

Self Cite

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The effects of unsaturated fatty acids on psoriasis: A two‐sample Mendelian randomization study

Lei

Chen

Cheng

et al. 2023

Food Science & Nutrition

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Unsaturated fatty acids have been reported to be associated with the risk of psoriasis. However, the causal relationship between them remains unclear This study aimed to explore the causal relationship between unsaturated FAs and psoriasis. Firstly, we obtained genome‐wide association study (GWAS) data for psoriasis from the FINNGEN database (number of cases = 4510, number of controls = 212,242) and different FA levels (number of samples = 114,999) from the IEU OpenGWAS Project. Secondly, the genetic correlation coefficient was calculated using linkage disequilibrium fractional regression. Thirdly, a two‐sample Mendelian randomization (MR) analysis was performed using independent instrumental variables (p < 5 × 10−8) to determine the direction of randomization. Finally, expression quantitative trait loci (eQTL)‐related analyses of common single nucleotide polymorphisms (SNPs) were carried out to explore the potential molecular mechanisms of unsaturated FAs affecting psoriasis. We found that an increase in the ratio of monounsaturated fatty acids (MUFAs) to total fatty acids could increase the risk of psoriasis (inverse‐variance weighted [IVW], adjusted odds ratio [OR] = 1.175; adjusted 95% confidence interval [CI] = 1.045–1.321; adjusted p = .007). However, an increase in the ratio of polyunsaturated fatty acids (PUFAa) to total fatty acids could decrease the risk of psoriasis (IVW, adjusted OR = 0.754; adjusted 95% CI = 0.631–0.901; adjusted p = .002). Moreover, an increase in the ratio of PUFAs to MUFAs could decrease the risk of psoriasis (IVW, adjusted OR = 0.823; adjusted 95% CI = 0.715–0.948; adjusted p = .007). The heterogeneity of data was eliminated, and pleiotropy was not detected. There was no statistical difference in the MR analysis of other fatty acids indices with psoriasis. Further, no statistically significant evidence was found to verify a causal relationship between psoriasis and fatty acid levels in reverse MR. Functional enrichment analysis showed that these eQTL related to common SNPs were mainly involved in organic ion transport, choline metabolism, and the expression of key metabolic factors mediated by PKA, ChREBP, and PP2A. Our study indicated that the ratio of MUFAs to total fatty acids had a positive causal effect on psoriasis, while the ratio of PUFAs to total fatty acids and the ratio of PUFAs to MUFAs had a negative causal effect on psoriasis. Moreover, PKA‐, PP2A‐, and ChREBP‐mediated activation of metabolic factors may play an important role in this process.

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Adipocyte Fatty Acid‐Binding Protein as a Novel Marker of Psoriasis and Clinical Response to Acitretin

Baran

Kiluk

Świderska

et al. 2019

Lipids

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Psoriasis is a systemic disease associated with metabolic syndrome and cardiometabolic diseases. Adipocyte fatty acid‐binding protein (A‐FABP, FABP4) is a relevant mediator of lipid metabolism and several comorbidities development. Aim of the study was to explore the possible role of FABP4 in psoriasis and assess its relationship with disease activity, inflammation or metabolic disturbances, and impact of systemic treatment. Fasting blood samples were obtained from 33 patients with active plaque‐type psoriasis before and after 12 weeks of therapy and from 11 healthy volunteers. Serum FABP4 concentrations were analyzed by the enzyme‐linked immunosorbent assay (ELISA) and statistically analyzed for their correlations with clinical outcomes and the treatment introduced. Serum FABP4 levels were significantly increased in psoriatics compared to controls (p = 0.03). No relationship between the protein and psoriasis severity expressed through psoriasis area and severity index (PASI) was noted (p = 0.57). FABP4 did not correlate with CRP (p = 0.41), lipid profile, and body mass index (BMI) nor the glucose level or liver enzyme activity. FABP4 significantly correlated with morphotic blood elements. After total therapy, FABP4 did not statistically change (p = 0.07), but significantly decreased after administering acitretin (p = 0.03). FABP4 is a potential marker of psoriasis and clinical outcome after therapy with acitretin. Adipocyte‐type FABP may be related to hematological disorders or obesity‐mediated comorbidities in psoriasis.

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Serum fatty acid profile in psoriasis and its comorbidity

Cited by 55 publications

References 36 publications

The role of lipids in psoriasis

The role of lipids in psoriasis

The effects of unsaturated fatty acids on psoriasis: A two‐sample Mendelian randomization study

Adipocyte Fatty Acid‐Binding Protein as a Novel Marker of Psoriasis and Clinical Response to Acitretin

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