Serum Fatty Acid Compositions and Lipid Concentrations and Their Correlations.

Takita, Toshichika; Nakamura, Kotaro; Kimira, Mitsuru; Yamada, Noriko; Kobayashi, Yoshie; Innami, Satoshi

doi:10.3164/jcbn.20.149

Cited by 11 publications

(11 citation statements)

References 20 publications

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“…Prior to their addition to culture media, fatty acids were incubated with fatty acid–free albumin as previously described (26). Fatty acid concentrations used in the study were levels that are achievable in human serum and are physiologically relevant (27, 28).…”

Section: Methodsmentioning

confidence: 99%

Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n‐3 fatty acids

Curtis

Rees

Little

et al. 2002

Arthritis & Rheumatism

159

111

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Objective. To determine if n-3 polyunsaturated fatty acid (PUFA) supplementation (versus treatment with n-6 polyunsaturated or other fatty acid supplements) affects the metabolism of osteoarthritic (OA) cartilage.Methods. The metabolic profile of human OA cartilage was determined at the time of harvest and after 24-hour exposure to n-3 PUFAs or other classes of Conclusion. These studies show that the pathologic indicators manifested in human OA cartilage can be significantly altered by exposure of the cartilage to n-3 PUFA, but not to other classes of fatty acids.

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Section: Methodsmentioning

confidence: 99%

Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n‐3 fatty acids

Curtis

Rees

Little

et al. 2002

Arthritis & Rheumatism

159

111

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“…However, in our study, higher concentrations of n-6 PUFAs were associated with higher TG levels. A previous study also reported that mean compositions of PA, OlA, LiA, EPA, and DHA in healthy Japanese male subjects aged 50 to 59 years were 25, 21.3, 27.3, 2.4, and 4.0%, respectively [1], which were almost the same as those in our male patients ( Table 2). A previous study reported that the mean concentration of LiA was 2233.8 μmol/L (626.5 μg/ml) in healthy young adults in their 20s [10], which was almost the same as the concentration detected in our patients.…”

Section: Discussionsupporting

confidence: 86%

“…A previous study reported that TG concentration had a stronger relationship with n-6 PUFA than T-CHO concentration in healthy Japanese individuals with normal serum T-CHO and TG levels, and that correlation coefficient between TG and n-6 PUFA was negative, specifically, − 0.417 in men and − 0.330 in women [1]. In our elderly patients, the Spearman rank correlation polyunsaturated fatty acids, n-3 n-3 polyunsaturated fatty acids coefficient comparing TG and LiA was positive, specifically 0.5088 at AIS onset.…”

Section: Discussionmentioning

confidence: 93%

“…Previous studies have reported compositions of serum fatty acids (s-FAs) such as saturated fatty acids (SFAs), n-6 polyunsaturated fatty acids (n-6 PUFAs), n-9 monounsaturated fatty acid (n-9 MUFA), and n-3 polyunsaturated fatty acids (n-3 PUFAs), and their correlation with serum lipids (s-LPs) in healthy young or middle-aged human subjects [1][2][3][4][5]. The proportion of n-6 PUFAs, as a fraction of total fatty acids, decreases with increasing age.…”

Section: Introductionmentioning

confidence: 99%

“…The proportion of n-6 PUFAs, as a fraction of total fatty acids, decreases with increasing age. Compositions of eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) were found to be positively correlated with serum total cholesterol (T-CHO), compositions of stearic acid (StA) or oleic acid (OlA) were positively correlated with serum triglycerides (TGs), and compositions of linoleic acid (LiA) or arachidonic acid (AA) were negatively correlated with TGs [1].…”

Section: Introductionmentioning

confidence: 99%

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Features of serum fatty acids in acute ischaemic stroke patients aged 50 years or older

Mori

Yoshioka

2020

BMC Cardiovasc Disord

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Background: Serum fatty acid (s-FA) compositions and their correlation with serum lipids (s-LPs) such as total cholesterol (T-CHO) and triglycerides (TG) have been reported in healthy young subjects. However, little is known about such features in acute ischaemic stroke (AIS). The aim of our study was to investigate s-FA characteristics and their correlation with AIS in elderly patients. Methods: We conducted a cross-sectional study of patients aged 50 years or older who were admitted between September 2015 and March 2017 within 24 h of the first AIS onset. We evaluated concentrations and compositions of s-FAs and their association with s-LPs, age, and ischaemic stroke subtypes, including large-artery atherosclerosis (LAA), small-vessel occlusion (SVO), and cardioembolism (CE) or others. Results: One hundred ninety-one patients met our inclusion criteria. Their average age was 74.4 years, mean T-CHO and median TG were 203.4 and 94.5 mg/dl, respectively, and median or mean concentrations of palmitic acid (PA), oleic acid (OlA), linoleic acid (LiA), and docosahexaenoic acid (DHA) were 680.7, 602.5, 795.2, and 136.9 μg/ml, respectively, with mean compositions of 23.7, 21.3, 27.1, and 4.4%, respectively. PA, OlA, and LiA concentrations were weakly negatively associated with age and positively correlated with TG. In LAA or SVO (LAA_SVO) and CE or others (CE_O), mean age was 71.9 and 77.4 years (p < 0.001), mean T-CHO was 213.9 and 191.2 mg/dl (p < 0.0001), median TG was 106.5 and 88.5 mg/dl (p < 0.01), median PA was 717.2 and 648.4 μg/ml (p < 0.01), median OlA was 638.2 and 567.5 μg/ml (p < 0.01), and median LiA was 844.7 and 728.5 μg/ml (p < 0.01), respectively. DHA composition was weakly positively correlated with age. There were no differences in PA, OlA, LiA, and DHA compositions between LAA_SVO and CE_O. Conclusions: In AIS elderly patients, concentrations, rather than compositions of PA, OlA, and LiA, correlated with age, TG, and ischaemic stroke subtypes. Patients with LAA_SVO were younger and had higher concentrations of PA, OlA, and LiA than those with CE_O. There were no differences in such compositions between LAA_SVO and CE_O.

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Global survey of the omega-3 fatty acids, docosahexaenoic acid and eicosapentaenoic acid in the blood stream of healthy adults

Stark

Elswyk²,

Higgins

et al. 2016

Progress in Lipid Research

423

281

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Studies reporting blood levels of the omega-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), were systematically identified in order to create a global map identifying countries and regions with different blood levels. Included studies were those of healthy adults, published in 1980 or later. A total of 298 studies met all inclusion criteria. Studies reported fatty acids in various blood fractions including plasma total lipids (33%), plasma phospholipid (32%), erythrocytes (32%) and whole blood (3.0%). Fatty acid data from each blood fraction were converted to relative weight percentages (wt.%) and then assigned to one of four discrete ranges (high, moderate, low, very low) corresponding to wt.% EPA+DHA in erythrocyte equivalents. Regions with high EPA+DHA blood levels (>8%) included the Sea of Japan, Scandinavia, and areas with indigenous populations or populations not fully adapted to Westernized food habits. Very low blood levels (≤4%) were observed in North America, Central and South America, Europe, the Middle East, Southeast Asia, and Africa. The present review reveals considerable variability in blood levels of EPA+DHA and the very low to low range of blood EPA+DHA for most of the world may increase global risk for chronic disease.

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Serum Fatty Acid Compositions and Lipid Concentrations and Their Correlations.

Cited by 11 publications

References 20 publications

Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n‐3 fatty acids

Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n‐3 fatty acids

Features of serum fatty acids in acute ischaemic stroke patients aged 50 years or older

Global survey of the omega-3 fatty acids, docosahexaenoic acid and eicosapentaenoic acid in the blood stream of healthy adults

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