Serum exosomal tsRNA biomarkers: A novel strategy for identifying lupus nephritis

Abstract

Dear Editor,For effective treatment and control of systemic lupus erythematosus (SLE), it is pertinent to be able to precisely identify and predict lupus nephritis (LN). 1 The current gold standard for this is renal biopsy, but this is invasive, making it less attractive for dynamic monitoring of disease progression. 2,3 tRNA-derived small non-coding RNAs (tsRNAs), as a novel RNA biomarker, intricately involved in regulating various stages of gene expression, from TA B L E 1 Clinical and immunological characteristics of the systemic lupus erythematosus (SLE) participants. Training Verification Index SLE (LN-) LN SLE (LN-) LN HC Cases 17 23 105 108 80 Gender (male/female) 1/16 1/22 7/98 5/103 17/63