Serum Exosomal MicroRNA-186-5p Positively Correlates with Lipid Indexes, Coronary Stenosis Degree, and Major Adverse Cardiovascular Events in Coronary Heart Disease

Ren, Lingyun; Liu, Wei; Chen, Shanshan; Zeng, Haibo

doi:10.1620/tjem.2023.j097

Cited by 1 publication

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding miR-186-5p, a previous study indicates that serum exosomal miR-186-5p shows a good diagnostic performance for AMI, and its dysregulation in exosomes contributes to atherosclerosis by targeting lectin-like ox-LDL receptor-1 (LOX-1) ( 15 ). Additionally, another study reports that serum exosomal miR-186-5p is positively associated with lipid level, coronary stenosis degree, and MACE risk in coronary heart disease patients ( 16 ). Inspiringly, our recently published study observes that macrophages-delivered exosomal miR-186-5p inactivates the Src homology 2-containing inositol 5-phosphatase 2 (SHIP2)-mediated phosphatidylinositol 3-kinase (PI3 K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway to facilitate vascular smooth muscle cell (VSMC) viability and invasion, thereby promoting atherogenesis ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

Longitudinal change of serum exosomal miR-186-5p estimates major adverse cardiac events in acute myocardial infarction patients receiving percutaneous coronary intervention

Ren,

Liu,

Chen

et al. 2024

Front. Cardiovasc. Med.

Self Cite

View full text Add to dashboard Cite

ObjectiveOur recently published study discovers that exosomal microRNA (miR)-186-5p promotes vascular smooth muscle cell viability and invasion to facilitate atherosclerosis. This research aimed to explore the prognostic implication of serum exosomal miR-186-5p in acute myocardial infarction (AMI) patients receiving percutaneous coronary intervention (PCI).MethodsOne hundred and fifty AMI patients receiving PCI and 50 healthy controls (HCs) were screened. Serum exosomal miR-186-5p was detected by reverse transcriptase-quantitative polymerase chain reaction assay in AMI patients at admission and after PCI, as well as in HCs after enrollment. Major adverse cardiac events (MACE) were recorded during follow-up in AMI patients receiving PCI.ResultsSerum exosomal miR-186-5p was raised in AMI patients vs. HCs (P < 0.001). Besides, serum exosomal miR-186-5p was positively linked to body mass index (P = 0.048), serum creatinine (P = 0.021), total cholesterol (P = 0.029), and C-reactive protein (P = 0.018); while it was reversely linked with estimated glomerular filtration rate (P = 0.023) in AMI patients. Interestingly, serum exosomal miR-186-5p was correlated with the diagnosis of ST-segment elevation myocardial infarction (P = 0.034). Notably, serum exosomal miR-186-5p was decreased after PCI vs. at admission (P < 0.001). The 6-, 12-, 18-, and 24-month accumulating MACE rates were 4.5%, 8.9%, 14.8%, and 14.8% in AMI patients. Furthermore, serum exosomal miR-186-5p ≥3.39 (maximum value in HCs) after PCI (P = 0.021) and its decrement percentage <median (35%) decrement (P = 0.044) estimated elevated MACE in AMI patients.ConclusionSerum exosomal miR-186-5p is reduced after PCI, and its post-PCI high level or minor decrease estimates increased MACE risk in AMI patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Longitudinal change of serum exosomal miR-186-5p estimates major adverse cardiac events in acute myocardial infarction patients receiving percutaneous coronary intervention

Ren,

Liu,

Chen

et al. 2024

Front. Cardiovasc. Med.

Self Cite

View full text Add to dashboard Cite

show abstract

Serum Exosomal MicroRNA-186-5p Positively Correlates with Lipid Indexes, Coronary Stenosis Degree, and Major Adverse Cardiovascular Events in Coronary Heart Disease

Abstract: Serum exosomal microRNA-186-5p positively correlates with lipid indexes, coronary stenosis degree, and major adverse cardiovascular events in coronary heart disease

Cited by 1 publication

References 32 publications

Longitudinal change of serum exosomal miR-186-5p estimates major adverse cardiac events in acute myocardial infarction patients receiving percutaneous coronary intervention

Longitudinal change of serum exosomal miR-186-5p estimates major adverse cardiac events in acute myocardial infarction patients receiving percutaneous coronary intervention

Contact Info

Product

Resources

About