Serum Essential Trace Element Status in Women and the Risk of Endometrial Diseases: a Case–Control Study

Li, Danyang; Jiang, Tingting; Wang, Xin; Yin, Tao; Shen, Lingchao; Zhang, Zhikang; Zou, Weiwei; Liu, Yajing; Zong, Kai; Liang, Dan; Cao, Yunxia; Xu, Xiaofeng; Liang, Chunmei; Ji, Dongmei

doi:10.1007/s12011-022-03328-x

Cited by 6 publications

(5 citation statements)

References 46 publications

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“…[ 21 ], who observed lower levels of Zn and Cu as well as comparable Cu/Zn ratio in samples from patients with endometrial cancer compared with healthy controls. On the contrary, another recent and more complex study focused on endometrial diseases reported decreased zinc and increased copper serum levels [ 22 ]. Since only a slight decrease in Cu/Zn ratio was found in patients with endometriosis, whereas almost no difference was found between endometrial cancer and control group, the present study does not confirm the significance of this parameter in diagnostics or monitoring of this disease.…”

Section: Discussionmentioning

confidence: 99%

Serum trace element levels and activity of enzymes associated with oxidative stress in endometriosis and endometrial cancer

Rabajdová,

Špaková,

Smolko

et al. 2023

FEBS Open Bio

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Abstract:Endometriosis and endometrial cancer are closely related with oxidative stress. However, the direct relationship between copper and zinc levels and oxidative stress in the extracellular and intracellular space remains unclear. The presented study is focused on determination of serum Zn and Cu levels, glutathione concentration and enzyme activity in three groups: patients diagnosed with endometrial cancer (EC), patients diagnosed with endometriosis (EM) and a healthy control group. Spectrophotometric determination of trace elements revealed that levels of zinc and copper were lower in blood plasma of patients with endometriosis as compared with the other groups; however, there were no significant differences in the Cu/Zn ratio. Furthermore, significantly increased blood serum glutathione levels were detected in both EM and EC groups compared to the control group. While the activity of superoxide dismutase (SOD) was similar across the studied groups, we observed differences in the activity of other enzymes associated with oxidative stress, including glutathione peroxidase (GPx), glutathione reductase (GR) and glutathione S‐transferase (GST), between the control group and the EM and EC patients. Additionally, analysis of gene expression based on free circulating mRNA indicated significant differences in the expression of SOD isoenzymes between the patient groups and the control group; expression of GPx isoenzymes was also altered. Our results may have potential application in diagnostics as well as monitoring of endometriosis and endometrial cancer.

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Section: Discussionmentioning

confidence: 99%

Serum trace element levels and activity of enzymes associated with oxidative stress in endometriosis and endometrial cancer

Rabajdová,

Špaková,

Smolko

et al. 2023

FEBS Open Bio

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“…Logistic regression was utilized to compute odds ratios (ORs) and 95% con dence intervals (CIs) in order to evaluate the correlation between levels of trace metals and the risk of endometriosis. Continuous variables were transformed into categorical variables based on quartiles, and P for trend tests were conducted [22]. A signi cance threshold of P < 0.05 was applied for determining statistical signi cance.…”

Section: Statistical Analysesmentioning

confidence: 99%

Serum Copper to Zinc Ratio and Risk of Endometriosis: Insights from a Case-Control Study

Liu,

Cheng,

et al. 2024

Preprint

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The significance of trace metal elements in the development of endometriosis has garnered increasing interest. We aimed to investigate the relationship between serum copper (Cu), zinc (Zn), iron (Fe), magnesium (Mg) levels, and the Cu/Zn ratio with the risk of endometriosis. This study involved 568 infertile patients diagnosed with endometriosis, compared to 819 infertile patients without endometriosis (Control group). Basic characteristics, hormonal parameters, and essential trace elements of the patients were measured and analyzed. The findings indicated a notable decrease in serum Zn levels in the endometriosis group compared to controls, alongside a significant increase in the Cu/Zn ratio (P < 0.001). Restricted cubic spline analysis (RCS) revealed a linear relationship between Zn levels and the Cu/Zn ratio with the risk of endometriosis. Moreover, Zn levels exhibited a negative correlation with endometriosis risk (P trend = 0.005), while the Cu/Zn ratio displayed a positive correlation with endometriosis risk, even after adjusting for age, body mass index (BMI), and baseline hormones (P trend < 0.001). Compared to the first quartile of Cu/Zn ratio after adjustment, the odds ratios (ORs) with 95% confidence intervals (CIs) for the second and fourth quartiles were 1.97 (1.37, 2.83) and 2.63 (1.80, 3.84), respectively. This study provided evidence of decreased serum Zn levels and increased Cu/Zn ratio being associated with an elevated risk of endometriosis among infertile patients.

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“…Ample research has linked reproductive disorders and infertility to low Se status/Se deficiency while the outcome of assisted reproductive technologies (ARTs) in animals and humans with appropriate Se serum levels were associated with positive outcomes in conception, suggesting that an appropriate level of Se is essential for reproductive health [ 65 , 80 , 81 , 82 ]. This knowledge has directed contemporary research interests into exploring Se supplementation in both experimental animal models and in animal farming practice to enhance reproductive abilities.…”

Section: Selenium Nanoparticlesmentioning

confidence: 99%

Physiological Benefits of Novel Selenium Delivery via Nanoparticles

Mojadadi

Shao

et al. 2023

IJMS

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Dietary selenium (Se) intake within the physiological range is critical to maintain various biological functions, including antioxidant defence, redox homeostasis, growth, reproduction, immunity, and thyroid hormone production. Chemical forms of dietary Se are diverse, including organic Se (selenomethionine, selenocysteine, and selenium-methyl-selenocysteine) and inorganic Se (selenate and selenite). Previous studies have largely investigated and compared the health impacts of dietary Se on agricultural stock and humans, where dietary Se has shown various benefits, including enhanced growth performance, immune functions, and nutritional quality of meats, with reduced oxidative stress and inflammation, and finally enhanced thyroid health and fertility in humans. The emergence of nanoparticles presents a novel and innovative technology. Notably, Se in the form of nanoparticles (SeNPs) has lower toxicity, higher bioavailability, lower excretion in animals, and is linked to more powerful and superior biological activities (at a comparable Se dose) than traditional chemical forms of dietary Se. As a result, the development of tailored SeNPs for their use in intensive agriculture and as candidate for therapeutic drugs for human pathologies is now being actively explored. This review highlights the biological impacts of SeNPs on growth and reproductive performances, their role in modulating heat and oxidative stress and inflammation and the varying modes of synthesis of SeNPs.

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Serum Essential Trace Element Status in Women and the Risk of Endometrial Diseases: a Case–Control Study

Cited by 6 publications

References 46 publications

Serum trace element levels and activity of enzymes associated with oxidative stress in endometriosis and endometrial cancer

Serum trace element levels and activity of enzymes associated with oxidative stress in endometriosis and endometrial cancer

Serum Copper to Zinc Ratio and Risk of Endometriosis: Insights from a Case-Control Study

Physiological Benefits of Novel Selenium Delivery via Nanoparticles

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