Serum Essential Elements and Survival after Cancer Diagnosis

Lubiński, Jan; Lener, Marcin; Marciniak, Wojciech; Pietrzak, S.; Derkacz, Róża; Cybulski, Cezary; Gronwald, Jacek; Dębniak, Tadeusz; Jakubowska, Anna; Huzarski, Tomasz; Matuszczak, Milena; Pullella, Katherine; Sun, Ping; Narod, Steven A.

doi:10.3390/nu15112611

Cited by 7 publications

(5 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several previously published studies have found a moderate correlation between diminished serum Se levels and survival outcomes in individuals diagnosed with breast and colorectal cancers [ 15 , 16 ]. We also found that high Zn levels correlated with prolonged survival in laryngeal [ 17 ], lung, breast, and prostate cancer patients [ 20 ]. Likewise, low Fe levels can increase the risk of death, as we have shown among a cohort of patients with malignant melanoma and lung cancer [ 5 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients

Pietrzak,

Marciniak,

Derkacz

et al. 2024

Nutrients

Self Cite

View full text Add to dashboard Cite

The most prevalent type of cancer among males is prostate cancer. Survival is considered quite good, but it can be further improved when risk factors are optimized. One of these factors is micronutrients, including Se and Zn. To our knowledge, the interaction between Se and Zn and prostate cancer remains undescribed. This study aimed to investigate the optimal levels of selenium (Se) and zinc (Zn) and their impact on the survival of individuals diagnosed with prostate cancer. A total of 338 prostate cancer patients were enrolled in this study, which was conducted in Poland between 2009 and 2015. Mass spectrometry, which uses inductively coupled plasma mass, was used to assess serum element levels before treatment. The study participants were categorized into quartiles (QI-QIV) based on the distributions of Se and Zn levels observed among surviving participants. Cox regression was used to assess the association between serum Se and Zn levels and the survival of prostate cancer patients. Our results reveal the effect of combined Se and Zn levels on survival in prostate cancer patients (SeQI-ZnQI vs. SeQIV-ZnQIV; HR = 20.9). These results need further research to establish Se/Zn norms for different populations.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Additionally, it forms an integral part of structural and regulatory proteins, including transcription factors, establishing “zinc fingers” that facilitate DNA binding. Zn levels have been linked to survival in prostate, breast, lung, and laryngeal cancers [ 17 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients

Pietrzak,

Marciniak,

Derkacz

et al. 2024

Nutrients

Self Cite

View full text Add to dashboard Cite

show abstract

“…Studies have found that cancer patients have elevated copper levels in both their serum and cancer tissue in a multitude of cancers such as oral, ovarian, gastric, breast, renal, thyroid, esophageal, lung, gallbladder, liver, pancreatic, and prostate cancers [5]. In specific cases, such as colorectal and breast cancer, elevated serum copper levels have been associated with cancer staging and progression [119]. Conversely, decreased serum copper levels have been correlated with colorectal and endometrial cancer [5].…”

Section: Copper Serum Levels and Cancermentioning

confidence: 99%

Cuproptosis: Unraveling the Mechanisms of Copper-Induced Cell Death and Its Implication in Cancer Therapy

Springer,

Humayun,

Skouta

2024

Cancers

View full text Add to dashboard Cite

Copper, an essential element for various biological processes, demands precise regulation to avert detrimental health effects and potential cell toxicity. This paper explores the mechanisms of copper-induced cell death, known as cuproptosis, and its potential health and disease implications, including cancer therapy. Copper ionophores, such as elesclomol and disulfiram, increase intracellular copper levels. This elevation triggers oxidative stress and subsequent cell death, offering potential implications in cancer therapy. Additionally, copper ionophores disrupt mitochondrial respiration and protein lipoylation, further contributing to copper toxicity and cell death. Potential targets and biomarkers are identified, as copper can be targeted to those proteins to trigger cuproptosis. The role of copper in different cancers is discussed to understand targeted cancer therapies using copper nanomaterials, copper ionophores, and copper chelators. Furthermore, the role of copper is explored through diseases such as Wilson and Menkes disease to understand the physiological mechanisms of copper. Exploring cuproptosis presents an opportunity to improve treatments for copper-related disorders and various cancers, with the potential to bring significant advancements to modern medicine.

show abstract

“…ClinChek ®® Serum Control Level I (Recipe, Munich, Germany) was used as a reference material. Detailed information about the analytical procedures were described previously [50].…”

Section: Analytical Proceduresmentioning

confidence: 99%

Serum Levels of Copper and Zinc and Survival in Breast Cancer Patients

Szwiec,

Marciniak,

Derkacz

et al. 2024

Nutrients

Self Cite

View full text Add to dashboard Cite

There is emerging interest in the relationship between several serum micronutrients and the prognosis of patients with breast cancer. The relationship between serum zinc and copper levels and breast cancer prognosis is unclear. In our study, we included 583 patients with breast cancer diagnosed between 2008 and 2015 in the region of Szczecin, Poland. In a blood sample obtained before treatment, serum zinc and copper levels were quantified by mass spectroscopy. Each patient was assigned to one of four categories (quartiles) based on the distribution of the elements in the entire cohort. Patients were followed from diagnosis to death over a mean of 10.0 years. The 10-year overall survival was 58.3% for women in the highest and 82.1% for those in the lowest quartile of serum copper/zinc ratio (p < 0.001). The multivariate hazard ratio (HR) for breast cancer death was 2.07 (95% CI 1.17–3.63; p = 0.01) for patients in the highest quartile of serum copper/zinc ratio compared to those in the lowest. There is evidence that the serum zinc level and copper/zinc ratio provide an independent predictive value for overall survival and breast cancer-specific survival after breast cancer diagnosis.

show abstract

Serum Essential Elements and Survival after Cancer Diagnosis

Cited by 7 publications

References 63 publications

Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients

Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients

Cuproptosis: Unraveling the Mechanisms of Copper-Induced Cell Death and Its Implication in Cancer Therapy

Serum Levels of Copper and Zinc and Survival in Breast Cancer Patients

Contact Info

Product

Resources

About