Serum erythropoietin titers in the aged

Mori, Mayumi; Murai, Y; Hirai, Makiko; Kawakami, Masayo; Saito, Tsunehiro; Takanashi, Naoki; Urabe, Akio; Takaku, Fumimaro

doi:10.1016/0047-6374(88)90118-2

Cited by 17 publications

(13 citation statements)

References 12 publications

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“…To our knowledge, there are only two studies on EPO concentrations in the elderly [6,7]. One study reported that the mean EPO concentration in normal elderly sub jects was 20.4 ± 10.4 mU/ml (n = 78: age distribution: 70-89 years), which was not significantly higher than that in younger con trols (n = 127, mean EPO concentration: 15.7 ± 1.3 mU/ml, age distribution: 22-46 years) [6].…”

Section: Discussionmentioning

confidence: 99%

“…One study reported that the mean EPO concentration in normal elderly sub jects was 20.4 ± 10.4 mU/ml (n = 78: age distribution: 70-89 years), which was not significantly higher than that in younger con trols (n = 127, mean EPO concentration: 15.7 ± 1.3 mU/ml, age distribution: 22-46 years) [6]. In the other study, the mean EPO concentration in normal elderly subjects was 10.8 ± 6.4 mU/ml (n = 25; age distribution: 60-82 years), which was slightly lower than that in younger controls (n = 30, mean EPO concentration: 13.1 ± 5.5 mU/ml, age distri bution: less than 65 years) [7], However, EPO concentrations should be compared for similar Hb levels [11]; thus, the difference in results of the three studies may be due to dif ferences in Hb concentrations of the subjects studied.…”

Section: Discussionmentioning

confidence: 99%

“…Recent radioimmu noassay (R1A) techniques enable us to mea sure serum erythropoietin (EPO) concentra tions with a high sensitivity and specificity [10]. Scant information is available regard ing the effect of age on serum EPO concen tration [6,7], In this study, we measured serum EPO concentrations using RIA and several red cell parameters in 156 elderly subjects in order to clarify the relationship between EPO and Hb concentrations in the elderly. …”

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confidence: 99%

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Serum Erythropoietin Levels in the Elderly

1991

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We evaluated the relationship between erythropoietin (EPO) and hemoglobin (Hb) concentrations in 156 normal subjects ranging from 60 to 98 years old. EPO was determined by a radioimmunoassay. The serum EPO concentration in subjects with Hb concentrations greater than 12.0 g/dl (26.9 ± 15.2 mU/ml), was significantly higher than that in younger controls (15.8 ± 5.0 mU/ml, p < 0.001). No sex difference in serum EPO level was detected. In addition, there was an inverse semilogarithmic relationship between EPO and Hb concentrations in subjects with Hb concentrations less than 12.0 g/dl (r = ––0.559, p < 0.001). EPO concentrations in the elderly were lower than those in young subjects with iron deficiency anemia with the same Hb level. Thus, in the elderly, a high EPO concentration may be preventing a decrease in the Hb concentration. However, a decreased EPO response to low Hb concentrations may be a contributing factor in anemia in the elderly.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Serum Erythropoietin Levels in the Elderly

1991

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“…Thus, anemia without any apparent cause, including iron, folate, or vitamin B 12 deficiency, chronic infection, chronic inflammation, or malignancy, is often found in the elderly and has been called senile anemia [lo]. The etiology of this anemia has been investigated but remains obscure [10][11][12][13][14][15][16][17][18] and EPO level has not been investigated yet. To investigate the EPO response to senile anemia, we mea-0 1992 Wiley-Liss, Inc.…”

Section: Introductionmentioning

confidence: 99%

Reduced erythropoietin secretion in senile anemia

et al. 1992

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To investigate the etiology of the age-related decrease in hemoglobin (Hb) concentration, we measured serum erythropoietin (EPO), serum iron, total iron binding capacity, and serum ferritin levels in 247 elderly subjects aged 60-99 years. EPO levels were determined by radioimmunoassay. An age-related increase in the serum EPO concentration (r = 0.220; P < 0.01) and a significant inverse relationship between EPO and Hb concentrations were found in normal elderly subjects without anemia (r = -0.302; P < 0.001), but not in 111 younger controls. Serum EPO levels were slightly higher in elderly subjects with pre-anemic iron deficiency than in the normal elderly subjects (P < 0.05). These results suggest that the EPO secretion is accelerated in the elderly even though the Hb remains above 12.0 g/dl, probably as a compensatory mechanism for peripheral tissue hypoxia. An inverse relationship between the EPO and Hb concentrations was found in the elderly subjects with iron deficiency anemia, but not in those with unexplained senile anemia. The changes of EPO levels were also assessed in 20 elderly subjects who had developed anemia when reviewed after 12 months. Serum EPO levels increased in relation to the decrease in Hb concentration in those with iron deficiency anemia, but not in those with unexplained senile anemia. Reduced EPO secretion thus seems to play a role in the progression of unexplained senile anemia, and recombinant human EPO may possibly be effective for treating this type of anemia by mobilizing excess iron.

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“…In the healthy group, the erythropoietin levels were in the range of normal adult values, as shown in all the stud ies performed in elderly patients, although there is some discrepancy between the views of different authors. Indeed, Mori et al [22] and Powers et al [23] did not find any differ ence between erythropoietin levels in elderly and younger non-anaemic controls, whereas Kario et al [24] reported an age-related in- A similar erythropoietin increase was observed in patients with haemoglobin levels rang ing from 110 to 85 g/1. whereas a significantly higher erythropoietin response was obtained for haemoglobin levels inferior to 85 g/1.…”

Section: Discussionmentioning

confidence: 79%

Factors Involved in the Anaemia of Chronic Disorders in Elderly Patients

et al. 1997

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Erythropoietin secretion was evaluated in the anaemia of chronic disorders in elderly patients, since it has been shown that this secretion is impaired in adults. We looked for a possible role of inflammatory cytokines: tumor necrosis factor-α (TNFα) and interleukin-1β (IL-1β) on erythropoietin production. The influence of nutritional status on the anaemia was also investigated. Erythropoietin secretion was significantly increased in elderly patients with anaemia of chronic disorders (ACD) and inversely correlated with haemoglobin concentrations in infectious and inflammatory diseases. Plasma TNFα levels were significantly enhanced only in cancerous patients, but no correlation could be established between TNFα and erythropoietin or haemoglobin. No noticeable increase of IL-1β levels was observed in ACD. These findings suggest that systemic TNFα or IL-1β are not involved in the erythropoietin response to ACD. Albumin levels were decreased in anaemic patients. Further investigations of the effects of a nutritional supplementation in elderly patients with ACD may be of interest.

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Serum erythropoietin titers in the aged

Cited by 17 publications

References 12 publications

Serum Erythropoietin Levels in the Elderly

Serum Erythropoietin Levels in the Elderly

Reduced erythropoietin secretion in senile anemia

Factors Involved in the Anaemia of Chronic Disorders in Elderly Patients

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