Serum erythropoietin level in anemia of chronic kidney disease - experience of a Romanian medical centre / Nivelul eritropoietinei serice în anemia din boala renală cronică - experiența unui centru medical românesc

Abstract

In this study, different aspects of anemia in chronic kidney disease have been observed, starting from the fact that the severity of anemia is associated with the degree of kidney dysfunction, the main cause being the erythropoietin deficiency, which is synthesized mostly by the kidneys. 58 persons were included in this study (r = 0.71), hemoglobin (r = 0.65) and hematocrit (r = 0.73), as well as negative associations between creatinine and the number of erythrocytes (r = -0.72), hemoglobin (r = -0.86) and hematocrit (r = -0.88). In patients with kidney transplantation and anemia we observed positive correlations between erythropoietin and the number of erythrocytes (r = 0.69), between the glomerular filtration rate and the number of erythrocytes (r = 0.78) and erythropoietin (r = 0.97), as well as negative correlations between proteinuria and the number of erythrocytes (r= -0.89), hemoglobin (r= -0.72), hematocrit (r = -0.72), and erythropoietin (r = -0.67), and between creatinine and the number of erythrocytes (r = -0.75) and erythropoietin (r = -0.86 (r = -0.89), hemoglobina (r = -0.72), hematocritul (r = -0.72), eritropoietina (r = -0.67), şi ale creatininei cu numărul eritrocitelor (r = -0.75) şi eritropoietina (r = -0.86).

Serum Erythropoietin in Patients with Chronic Renal Failure in the Predialysis Stage

“…The review shows that most of them have been published in the period 1977-2000 year. Many of these publications [8][9][10][11] summarise the results of studies with a very small number of people.…”

“…Pop et al [11] studied 19 patients with nondialysis CRF. They discovered that the patients treated with erythropoiesis-stimulating agents had twice as high serum erythropoietin levels as the patients who had not been treated with erythropoiesis-stimulating agents.…”

Effect of long period treatment with erythropoiesis stimulating agents on clinically and laboratory parameters in hemodialysis autosomal dominant polycystic kidney disease patients

“…A relatively small part of the chronic hemodialysis (HD) patients maintain acceptable levels of hemoglobin (Hb) without requiring erythropoiesis-stimulating agents (ESA) or blood transfusions over longer periods of time (1). Naturally occurring Hb concentrations above 12 g/dL do not associate with increased mortality in HD patients.…”