Serum enzyme studies in muscle disease: Part II Serum creatine kinase activity in muscular dystrophy and in other myopathic and neuropathic disorders

Abstract

It has been established that the levels of certain enzymes are elevated in the serum of patients suffering from muscular dystrophy. Previous studies

Serum and Muscle Creatine Kinase Isoenzymes and Serum Aspartate Aminotransferase Isoenzymes in Progressive Muscular Dystrophy

“…A much smaller increase is found in the other forms of muscular dys trophy (limb-girdle type, facioscapulohumeral type, ocular type, oculo-pharingeal and distal types). Even a smaller increase is found in dystrophia myotonica [13,16,24,27,29,36,39]. The very high values found in the pre-clinical and early stages of Duchenne type and to a lesser extent in the Becker type and limb-girdle type are not main-…”

Clinical and pathological study of a case of congenital muscular dystrophy

“…was 58 units per ml. per minute, andtheserumcreatine kinase level 12-6 unitsaccording to the method of Pearce, Pennington, and Walton (1964) LIGHT MICROSCOPY The muscle fibres were everywhere embedded in dense connective tissue; they showed great diversity of size from considerable hypertrophy to extreme atrophy (Fig. 4).…”

Studies of Myosin in Hereditary Muscular Dystrophy in Mice*

“…The increase in Asp [3] was not statistically significant, nor were the differences in Thr [1 ] and Arg [1]. The remaining nine amino acids found in dystrophic myosin differed by less than one residue and in each case by ' 2.5 % of normal.…”

“…Biochemical studies of hereditary human and animal progressive muscular dystrophy have revealed a variety of abnormalities such as elevated serum enzymes and lowered muscle enzyme activity, increased creatine excretion, and lowered muscle potassium content, which have been recently reviewed (1,2). These changes are, however, generally considered to be secondary to muscle destruction (2)(3)(4). A muscle protein abnormality has been suggested in recent studies by Kruh, Dreyfus, Schapira, and Gey (5), and by Simon, Gross, and Lessell (6), showing an increased rate of muscle protein catabolism in hereditary dystrophy of mice.…”