Serum Enzyme Patterns in Acute Poisoning with Organochlorine Insecticides

In vivo effects of dietary mirex on hepatic lactic dehydrogenase and glutamic oxaloacetic transaminase levels of the rat

“…In the present study, both serum LDH and GOT levels increased as the tissue enzyme levels decreased. Luckens and Phelps (1969) reported significant increases in serum GOT, GPT, and LDH levels after single, acute doses of DDT, aldrin, dieldrin, and endrin. Heptachlor has also been shown to increase serum GPT and serum aldolase levels in rats (Krampl, 1970).…”

“…Little information is available on the in organochlorine compound effects on soluble tissue enzymes. The studies which have been reported deal mainly with serum changes in acute dosages of organochlorine compounds (Krampl, 1970; Luckens and Phelps, 1969), although Komer (1972) reported reduction of certain enzymes in liver tissue levels of yearling lamb after 125 days of dieldrin treatment.…”

Relationship between dietary protein level and enzymatic changes in acute poisoning of rats with chlorfenvinphos

“…In the investigations of LUCKENS et al [9] the activity of AspAT and AlaAT increased in the serum of mice after oral administration of one dose producing manifestations of intense poisoning with convulsions of such organochlorine insecticides as DDT, aldrin, dieldrin and endrin. During acute poisoning with chlorfenvinphos in the present study the activity of AspAT and AlaAT in the serum increased only in female rats kept on the low-protein diet, which might be an evidence of an increased susceptibility of these rats to biochemical damage to the cells, mainly in the liver, since no morphological changes were observed in the organs of these rats.…”

Etat nutritionnel du rat au cours (Tune réalimentation faisant suite à une mobilisation massive du DDT par le jeûne

“…Cependant, à la fin de la période d'intoxication, l'hyper trophie hépatique chez les animaux recevant le DDT était, d'une part, beaucoup plus im portante [8] et, d'autre part, la différence en tre les deux lots d'animaux diminue encore au cours du jeûne [9] et de la réalimentation. De plus, on n'observe pas de variation signi ficative du taux de GOT et de GPT plasmati que qui augmentent lors d'une atteinte hépa tique sous l'effet du DDT [17], il semble donc que cette hypertrophie ne traduise pas une atteinte importante et irréversible des cellules hépatiques sous l'effet du DDT.…”