Serum Endocan Levels in Children with Febrile Neutropenia

Kıral, Eylem; Dinleyici, Ener Çağrı; Bozkurt-Turhan, Ayse; Bör, Özcan; Akgün, Yurdanur; N, Akgün

doi:10.4081/hr.2016.6110

Cited by 5 publications

(4 citation statements)

References 14 publications

(23 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result was also supported by the present study indicating that PCT, WBC, CRP levels and the presence of fever were not correlated. In the present study, a positive and significant correlation was found between the Endocan level and the fever elevated after 24 h and this is parallel to the studies conducted with septic patients [26] and febrile neutropenic patients [27]. This is associated with the fact that inflammation or infection can show itself with fever without impairment in laboratory data [27].…”

Section: Discussionsupporting

confidence: 88%

Can endocan be a new biomarker in ventilator‐associated pneumonia?

Küpeli

Salcan

Kuzucu

et al. 2018

The Kaohsiung J of Med Scie

View full text Add to dashboard Cite

Ventilator‐Associated Pneumonia (VAP) is a hospital‐acquired bacterial infection with high incidence and mortality rate. The aim of this study is to investigate the correlation between the Endocan level and development of VAP and whether or not this correlation was correlated with the clinical findings. Demographic data, white blood cell (WBC) count, procalcitonin (PCT), c‐reactive protein (CRP), and fever levels of 60 patients were recorded in serial measurements for 5 days. When there was the presence of fever or elevated Endocan, alveolar lavage culture was taken and chest radiographies were taken. Correlations of the Endocan levels with the culture results and laboratory values were examined. The rate of VAP was found as 10.4/1000 mechanical ventilator days. Endocan levels were significantly higher in patients with VAP (p < 0.05). However, there was no significant difference among PCT, WBC, CRP measurements (p > 0.05). No correlation was found between Endocan levels and PCT, WBC and CRP levels in those with VAP (p > 0.05). A significant correlation was found between the Endocan level and the elevated fever 24 h later (p:0.001). The serum Endocan level on the day 3 had a specificity of 73.3%, a sensitivity of 68.9%, positive predictive value of 44%, and negative predictive value of 88.5% at the cut off level of 9.17 ng/mL. In this study, it was determined that high Endocan levels were associated with the development of VAP. The present study suggested that Endocan can be used as a screening tool for the development of VAP. Clinical Trials.gov ID NCT02916277.

show abstract

Section: Discussionsupporting

confidence: 88%

Can endocan be a new biomarker in ventilator‐associated pneumonia?

Küpeli

Salcan

Kuzucu

et al. 2018

The Kaohsiung J of Med Scie

View full text Add to dashboard Cite

show abstract

“…Signs of systemic activation of microvessels can be considered the accumulation of cast-off endothelial cells (CD144+ cells) in the bloodstream, as well as the soluble forms of certain adhesion receptors: endocan, E-selectin, VCAM-1 and ICAM-1 (Pierrakos and Vincent 2010;Dunne 2015;Kiral 2016). However, sE-selectin and sICAM-1, according to our data, can only be considered as additional criteria to estimate SIR (i.e., a relatively small amplitude of changes in blood concentration in sepsis and acute trauma) (Zotova et al 2016).…”

Section: Commonly Used Sir Indicatorsmentioning

confidence: 99%

Integral estimation of systemic inflammatory response under sepsis

Zotova¹,

Zhuravleva²,

Зубова³

et al. 2020

gpb

View full text Add to dashboard Cite

Currently, the most significant mediators of the systemic inflammatory response (SIR), specific to the development of critical states in sepsis, have the chaotic changes of concentrations in the blood. The solution to the problem is using integral indicators. A scoring scale of the SIR (0-16 points) is proposed based on the determination in the blood plasma of CRP, TNF-α, IL-6, IL-8 and IL-10. The scale was used in the survey of 167 patients with a diagnosis of sepsis (43 patients with sepsis according to definitions of "Sepsis-1 or 2" and 124 patients with sepsis according to the criteria of "Sepsis-3"); septic shock was verified in 31 cases and in 48 cases lethal outcomes were recorded. The association of SIR with critical complications of sepsis was revealed, especially under acute septic shock and in cases of a "second wave" (days 5-7) of critical complications. In contrast, prolonged/ subacute sepsis (more than 14 days) under tertiary peritonitis is characterised by a lesser dependence of the criticality of the state on the severity of SIR. The proposed scale is an open system and allows you to modify the range of used particular indicators that are compatible by pathogenetic and diagnostic significance.

show abstract

“…Thus, the results from our previous study together with the results presented in Table S1 suggest that endocan is a better biomarker than the p14 endocan fragment for characterization of patient heterogeneity also for the majority of acute leukemia patients not requiring transfer to intensive care units for life-supportive therapy. Previous studies have shown that systemic endocan levels are low in patients with chemotherapy-induced neutropenia and no signs of complicating infections, the levels then increase during febrile neutropenia with increased CRP and then normalize when the signs of infection disappear during antibiotic treatment [3,78]. Thus, the systemic endocan level seems to increase as a part of the acute phase reaction during febrile neutropenia, both for children and adult patients.…”

mentioning

confidence: 92%

Endocan in Acute Leukemia: Current Knowledge and Future Perspectives

et al. 2022

View full text Add to dashboard Cite

Endocan is a soluble dermatan sulfate proteoglycan expressed by endothelial cells and detected in serum/plasma. Its expression is increased in tumors/tumor vessels in several human malignancies, and high expression (high serum/plasma levels or tumor levels) has an adverse prognostic impact in several malignancies. The p14 endocan degradation product can also be detected in serum/plasma, but previous clinical studies as well as previously unpublished results presented in this review suggest that endocan and p14 endocan fragment levels reflect different biological characteristics, and the endocan levels seem to reflect the disease heterogeneity in acute leukemia better than the p14 fragment levels. Furthermore, decreased systemic endocan levels in previously immunocompetent sepsis patients are associated with later severe respiratory complications, but it is not known whether this is true also for immunocompromised acute leukemia patients. Finally, endocan is associated with increased early nonrelapse mortality in (acute leukemia) patients receiving allogeneic stem cell transplantation, and this adverse prognostic impact seems to be independent of the adverse impact of excessive fluid overload. Systemic endocan levels may also become important to predict cytokine release syndrome after immunotherapy/haploidentical transplantation, and in the long-term follow-up of acute leukemia survivors with regard to cardiovascular risk. Therapeutic targeting of endocan is now possible, and the possible role of endocan in acute leukemia should be further investigated to clarify whether the therapeutic strategy should also be considered.

show abstract

Serum Endocan Levels in Children with Febrile Neutropenia

Cited by 5 publications

References 14 publications

Can endocan be a new biomarker in ventilator‐associated pneumonia?

Can endocan be a new biomarker in ventilator‐associated pneumonia?

Integral estimation of systemic inflammatory response under sepsis

Endocan in Acute Leukemia: Current Knowledge and Future Perspectives

Contact Info

Product

Resources

About